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Synthesis 2023; 55(20): 3364-3372
DOI: 10.1055/a-2147-2620
DOI: 10.1055/a-2147-2620
paper
Rhodium-Catalyzed C–H Activation of 2-Arylquinazolinones and Cyclization with Elemental Sulfur via C–S/S–N Bond Formation to Access 7H-Benzo[4,5]isothiazolo[3,2-b]quinazolinones
Financial support from National Natural Science Foundation of China (no. 21762020 and 22261027) is gratefully acknowledged.
Abstract
An efficient method for the synthesis of 7H-benzo[4,5]isothiazolo[3,2-b]quinazolin-7-ones by the reaction of 2-arylquinazolin-4(3H)-ones and elemental sulfur is described. The rhodium-catalyzed C–H activation of 2-arylquinazolinones and cyclization with elemental sulfur via one-step formation of C–S/N–S bonds to give the corresponding 7H-benzo[4,5]isothiazolo[3,2-b]quinazolinones is realized in good to high yields with good functional group tolerance.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2147-2620.
- Supporting Information
Publication History
Received: 29 May 2023
Accepted after revision: 02 August 2023
Accepted Manuscript online:
02 August 2023
Article published online:
07 September 2023
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For excellent reports, see:
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