Download PDF
veterinär spiegel 2023; 33(03): 106-115
DOI: 10.1055/a-2120-4830
Kleintiere & Heimtiere

Therapieempfehlung der chronischen Nierenerkrankung bei der Katze

Simone Guntermann
,
Kristin Rolinger
,
Julia A. Eichberger
› Further Information
Also available at
    Permissions and Reprints All articles of this category

Katzenpatienten mit chronischer Nierenerkrankung sollten nach Diagnostik und Staging therapeutisch optimal versorgt werden. Lassen Sie sich von uns durch die IRIS-Stadien führen und zeigen, welche Optionen es für welches Stadium gibt.

Publication History

Article published online:
19 September 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • Literatur

  • 1 International Renal Interest Society (IRIS). Treatment Recommendation for chronic kidney disease in cats. 2023
    PubMedGoogle Scholar
  • 2 Brown SA, Roura X. (Original author 2016, updated 2022). IRIS Education – systemic hypertension. Im Internet: http://www.iris-kidney.com
    Google Scholar
  • 3 Grauer GF. (2022) IRIS Education – Proteinuria. Im Internet: http://www.iris-kidney.com
    Google Scholar
  • 4 Quimby J. Ross S (Original author Polzin J [2016], updated 2022). IRIS Education – Diets for Cats with Chronic Kidney Disease. Im Internet: http://www.iris-kidney.com
    Google Scholar
  • 5 Vergnano D, Valle E, Bruni N. et al. Effectiveness of a feed supplement in advanced stages of feline chronic kidney disease. IRIS Prodotti della ricerca 2016 (01).
    Google Scholar
  • 6 Geddes RF, Finch NC, Syme HM. et al. The role of phosphorus in the pathology of chronic kidney disease. J Vet Emerg Crit Care 2013; 23: 122-133
    CrossrefPubMedGoogle Scholar
  • 7 Geddes RF, van den Broek DHN, Chang YM. et al. The effect of attenuating dietary phosphate restriction on blood ionized calcium concentrations in cats with chronic kidney disease and ionized hypercalcemia. J Vet Intern Med 2021; 35: 997-1007
    CrossrefPubMedGoogle Scholar
  • 8 Barber PJ, Rawlings JM, Markwell PJ. et al. Effect of dietary phosphate restriction on renal secondary hyperparathyroidism in the cat. J Small Anim Pract 1999; 40: 62-70
    CrossrefPubMedGoogle Scholar
  • 9 van den Broek H. IRIS Education 2022 – Hypercalcaemia in chronic kidney disease. Im Internet: http://iris-kidney.com
    Google Scholar
  • 10 Barber PJ, Elliott J. Feline chronic renal failure: calcium homeostasis in 80 cases diagnosed between 1992 and 1995. J Small Anim Pract 1998; 39: 108-116
    CrossrefPubMedGoogle Scholar
  • 11 Schenck PA, Chew DJ. Prediction of serum ionized calcium concentration by serum total calcium measurement in cats. Can J Vet Res 2010; 74: 209-213
    PubMedGoogle Scholar
  • 12 Schenck PA, Chew DJ, Nagode LA. et al. Chapter 6 – Disorders of Calcium: Hypercalcemia and Hypocalcemia A2. In: DiBartola SP. Hrsg. Fluid, Electrolyte, and Acid-Base Disorders in Small Animal Practice. 04. Saint Louis: W.B. Saunders; 2012: 120-194
    Google Scholar
  • 13 Schenck PA, Chew DJ. Hypercalcemia: a quick reference. J Vet Clin North Am Small Anim Pract 2008; 38: 449-453
    CrossrefPubMedGoogle Scholar
  • 14 Peacock M. Calcium metabolism in health and disease. J Am Soc Nephrol 2010; 5 Suppl 1: 23
    CrossrefPubMedGoogle Scholar
  • 15 Parker VJ, Harjes LM, Dembek K. et al. Association of Vitamin D Metabolites with Parathyroid Hormone, Fibroblast Growth Factor-23, Calcium and Phosphorus in Dogs with Various Stages of Chronic Kidney Disease. J Vet Intern Med 2017; 31: 791
    CrossrefPubMedGoogle Scholar
  • 16 Barber PJ. Parathyroid gland function in the ageing cat [PhD Thesis]. London: Royal Veterinary College, University of London; 1998: 289
    Google Scholar
  • 17 Levi M, Ellis MA, Berl T. Control of renal hemodynamics and glomerular filtration rate in chronic hypercalcemia. Role of prostaglandins, renin-angiotensin system, and calcium. J Clin Invest 1983; 71: 1624-1632
    CrossrefPubMedGoogle Scholar
  • 18 Midkiff AM, Chew DJ, Randolph JF. et al. Idiopathic hypercalcemia in cats. J Vet Intern Med 2000; 14: 619-626
    CrossrefPubMedGoogle Scholar
  • 19 Elliott J, Syme HM, Reubens E. et al. Assessment of acid-base status of cats with naturally occurring chronic renal failure. J Small Anim Pract 2003; 44: 65-70
    CrossrefPubMedGoogle Scholar
  • 20 Meghji S, Morrison MS, Henderson B. et al. pH dependence of bone resorption: mouse calvarial osteoclasts are activated by acidosis. Am J Physiol Endocrinol 2001; 280: E112-119
    CrossrefPubMedGoogle Scholar
  • 21 Bushinsky DA, Lechleider RJ. Mechanism of proton-induced bone calcium release: calcium carbonate-dissolution. Am J Physiol 1987; 253: F998-1005
    Google Scholar
  • 22 Block GA, Wheeler DC, Persky MS. et al. Effects of Phosphate Binders in Moderate CKD. J Am Soc Nephrol 2012; 23: 1407-1415
    CrossrefPubMedGoogle Scholar
  • 23 Hill KM, Martin BR, Wastney ME. et al. Oral calcium carbonate affects calcium but not phosphorus balance in stage 3–4 chronic kidney disease. Kidney Int 2013; 83: 959-966
    CrossrefPubMedGoogle Scholar
  • 24 Jamal SA, Vandermeer B, Raggi P. et al. Effect of calcium-based versus non-calcium-based phosphate binders on mortality in patients with chronic kidney disease: an updated systematic review and meta-analysis. Lancet 2013; 382: 1268-1277
    CrossrefPubMedGoogle Scholar
  • 25 Sprague SM, Llach F, Amdahl M. et al. Paricalcitol versus calcitriol in the treatment of secondary hyperparathyroidism. Kidney Int 2003; 63: 1483-1490
    CrossrefPubMedGoogle Scholar
  • 26 Polzin SR, Osborne C, Lulich J. et al. Clinical benefit of calcitriol in canine chronic kidney disease. J Vet Intern Med 2005; 19: 433
    Google Scholar
  • 27 Gunn-Moore DA, Dodkin SJ, Sparkes AH. An unexpectedly high prevalence of azotaemia in Birman cats. J Vet Med Surg 2002; 4: 165-166
    Google Scholar
  • 28 Hostutler RA, DiBartola SP, Chew DJ. et al. Comparison of the effects of daily and intermittent-dose calcitriol on serum parathyroid hormone and ionized calcium concentrations in normal cats and cats with chronic renal failure. J Vet Intern Med 2006; 20: 1307-1313
    CrossrefPubMedGoogle Scholar
  • 29 Finch NC. Hypercalcaemia in cats: The complexities of calcium regulation and associated clinical challenges. J Fel Med Surg 2016; 18: 387-399
    CrossrefPubMedGoogle Scholar
  • 30 van den Broek DH, Chang YM, Elliott J. et al. Chronic Kidney Disease in Cats and the Risk of Total Hypercalcemia. J Vet Intern Med 2017; 31: 465-475
    CrossrefPubMedGoogle Scholar
  • 31 Hardy BT, de Brito Galvao JF, Green TA. et al. Treatment of ionized hypercalcemia in 12 cats (2006–2008) using PO-administered alendronate. J Vet Intern Med 2015; 29: 200-206
    CrossrefPubMedGoogle Scholar
  • 32 Hostutler RA, Chew DJ, Jaeger JQ. et al. Uses and effectiveness of pamidronate disodium for treatment of dogs and cats with hypercalcemia. J Vet Intern Med 2005; 19: 29-33
    CrossrefPubMedGoogle Scholar
  • 33 Schauf S, Coltherd JC, Atwal J. et al. Clinical progression of cats with early-stage chronic kidney disease fed diets with varying protein and phosphorus contents and calcium to phosphorus ratios. J Vet Intern Med 2021; 35: 2797-2811
    CrossrefPubMedGoogle Scholar
  • 34 Ross SJ, Osborne CA, Kirk CA. et al. Clinical evaluation of dietary modification for treatment of spontaneous chronic kidney disease in cats. J Am Vet Med Assoc 2006; 229: 949-957
    CrossrefPubMedGoogle Scholar
  • 35 Elliott J, Rawlings JM, Markwell PJ. et al. Survival of cats with naturally occurring chronic renal failure: effect of dietary management. J Small Anim Pract 2000; 41: 235-242
    CrossrefPubMedGoogle Scholar
  • 36 Plantinga EA, Everts H, Kastelein AMC. et al. Retrospective study of the survival of cats with acquired chronic renal insufficiency offered different commercial diets. Vet Rec 2005; 157: 185-187
    CrossrefPubMedGoogle Scholar
  • 37 Geddes RF, Elliott J, Syme HM. The effects of feeding a renal diet on plasma fibroblast growth factor 23 concentrations in cats with stable azotemic chronic kidney disease. J Vet Intern Med 2013; 27: 1354-1361
    CrossrefPubMedGoogle Scholar
  • 38 Parker VJ. Nutritional Management for Dogs and Cats with Chronic Kidney Disease. J Vet Clin North Am Small Anim Pract 2021; 51: 685-710
    CrossrefPubMedGoogle Scholar
  • 39 Dobenecker B, Hertel-Bohnke P, Webel A. et al. Renal phosphorus excretion in adult healthy cats after the intake of high phosphorus diets with either calcium monophosphate or sodium monophosphate. J Anim Physiol Anim Nutr (Berl) 2018; 102: 1759-1765
    CrossrefPubMedGoogle Scholar
  • 40 Dobenecker B, Webel A, Reese S. et al. Effect of a high phosphorus diet on indicators of renal health in cats. J Feline Med Surg 2018; 20: 339-343
    CrossrefPubMedGoogle Scholar
  • 41 Hall JA, Fritsch DA, Jewell DE. et al. Cats with IRIS stage 1 and 2 chronic kidney disease maintain body weight and lean muscle mass when fed food having increased caloric density, and enhanced concentrations of carnitine and essential amino acids. Vet Rec 2019; 184: 190
    CrossrefPubMedGoogle Scholar
  • 42 Zoran DL. The carnivore connection to nutrition in cats. J Am Vet Med Assoc 2002; 221: 1559-1567
    CrossrefPubMedGoogle Scholar
  • 43 Zoran DL, Buffington CA. Effects of nutrition choices and lifestyle changes on the well-being of cats, a carnivore that has moved indoors. J Am Vet Med Assoc 2011; 239: 596-606
    CrossrefPubMedGoogle Scholar
  • 44 Laflamme DP, Hannah SS. Discrepancy between use of lean body mass or nitrogen balance to determine protein requirements for adult cats. Feline Med Surg 2013; 15: 691-697
    CrossrefPubMedGoogle Scholar
  • 45 Mitch WE. Dietary protein restriction in chronic kidney failure: Nutritional efficacy, compliance, and progression of kidney insufficiency. J Am Soc Nephrol 1991; 2: 823-831
    CrossrefPubMedGoogle Scholar
  • 46 Hills product guide 2021, KD dry. Im Internet: http://www.hillsvet.com/products/cat-food/pd-kd-feline-dry
    Google Scholar
  • 47 Mottet J, Kowollik N. Renaltec attenuates serum levels of indoxyl sulfate in geriatric cats. BSAVA Congress. 2019
    PubMedGoogle Scholar
  • 48 Chen CN, Chou CC, Tsai PSJ. et al. Plasma indoxyl sulfate concentration predicts progression of chronic kidney disease in dogs and cats. Vet J 2018; 232: 33-39
    CrossrefPubMedGoogle Scholar
  • 49 Ludwig J. Chronic kidney disease in cats-diagnosis, classification, treatment. Biologische Tiermedizin 2012; 29: 33-46
    Google Scholar
  • 50 Brandenburg U, Braun G, Klein P. et al. The Multicomponent, Multitarget Therapy SUC in Cats with Chronic Kidney Disease: A Multicenter, Prospectiv, Observational, Nonrandomized Cohort Study. Compl Med Res 2020; 27: 163-173
    Google Scholar
  • 51 Elliott J. (2022) IRIS Education – Treatment of Vomiting, Nausea and Inappetence in Cats with Chronic Kidney Disease. Im Internet: http://www.iris-kidney.com
    Google Scholar
  • 52 Elliott J, Barber PJ. Feline chronic renal failure: clinical findings in 80 cases diagnosed between 1992 and 1995. J Small Anim Pract 1998; 39: 78-85
    CrossrefPubMedGoogle Scholar
  • 53 Reynolds CA, Oyama MA, Rush JE. et al. Perceptions of quality of life and priorities of owners of cats with heart disease. J Vet Intern Med 2010; 24: 1421-1426
    CrossrefPubMedGoogle Scholar
  • 54 Bijsmans ES, Jepson RE, Syme HM. et al. Psychometric Validation of a General Health Quality of Life Tool for Cats Used to Compare Healthy Cats and Cats with Chronic Kidney Disease. J Vet Intern Med 2015; 30: 183-191
    CrossrefPubMedGoogle Scholar
  • 55 Quimby JM, Lunn KF. Mirtazapine as an appetite stimulant and anti-emetic in cats with chronic kidney disease: a masked placebo-controlled crossover clinical trial. Vet J 2013; 197: 651-655
    CrossrefPubMedGoogle Scholar
  • 56 Quimby JM, Gustafson DL, Samber BJ. et al. Studies on the pharmacokinetics and pharmacodynamics of mirtazapine in healthy young cats. J Vet Pharmacol Ther 2011; 34: 388-396
    CrossrefPubMedGoogle Scholar
  • 57 Quimby JM, Gustafson DL, Lunn KF. The pharmacokinetics of mirtazapine in cats with chronic kidney disease and in age-matched control cats. J Vet Intern Med 2011; 25: 985-989
    CrossrefPubMedGoogle Scholar
  • 58 Quimby JM, Benson KK, Summers SC. et al. Assessment of compounded transdermal mirtazapine as an appetite stimulant in cats with chronic kidney disease. J Feline Med Surg 2020; 22: 376-383
    CrossrefPubMedGoogle Scholar
  • 59 Quimby JM, Brock WT, Moses K. et al. Chronic use of maropitant for the management of vomiting and inappetence in cats with chronic kidney disease: a blinded, placebo-controlled clinical trial. J Feline Med Surg 2015; 17: 692-697
    CrossrefPubMedGoogle Scholar
  • 60 McLeland SM, Lunn KF, Duncan CG. et al. Relationship among serum creatinine, serum gastrin, calcium-phosphorus product, and uremic gastropathy in cats with chronic kidney disease. J Vet Intern Med 2014; 28: 827-837
    CrossrefPubMedGoogle Scholar