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Horm Metab Res 2023; 55(07): 487-492
DOI: 10.1055/a-2093-0260
Original Article: Endocrine Care

Metabolomic Profile of Insulin Resistance Women with Systemic Lupus Erythematosus

Pamela Munguía-Realpozo
1   Systemic Autoimmune Diseases Research Unit, Specialties Hospital UMAE, Instituto Mexicano del Seguro Social, Puebla, Mexico
2   Medicine School, Benemerita Universidad Autonoma de Puebla, Puebla, Mexico
,
Claudia Mendoza-Pinto 
1   Systemic Autoimmune Diseases Research Unit, Specialties Hospital UMAE, Instituto Mexicano del Seguro Social, Puebla, Mexico
3   Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico
,
Ivet Etchegaray-Morales
2   Medicine School, Benemerita Universidad Autonoma de Puebla, Puebla, Mexico
,
Angel David Osorio-Peña
2   Medicine School, Benemerita Universidad Autonoma de Puebla, Puebla, Mexico
,
Sandra Vélez-Pelcastre
2   Medicine School, Benemerita Universidad Autonoma de Puebla, Puebla, Mexico
,
Marco Antonio Escamilla-Márquez
2   Medicine School, Benemerita Universidad Autonoma de Puebla, Puebla, Mexico
,
Jorge Ayón-Aguilar
4   Research in Health Coordination, Instituto Mexicano del Seguro Social, Puebla, Mexico
,
Socorro Méndez-Martínez
4   Research in Health Coordination, Instituto Mexicano del Seguro Social, Puebla, Mexico
,
Mario García-Carrasco
2   Medicine School, Benemerita Universidad Autonoma de Puebla, Puebla, Mexico
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Abstract

The aims of this study were in systemic lupus erythematosus (SLE) patients: 1) to compare the metabolomic profile of insulin resistance (IR) with controls and 2) to correlate the metabolomic profile with other IR surrogates and SLE disease variables and vitamin levels. In this cross-sectional study, serum samples were collected from women with SLE (n=64) and gender- and age-matched controls (n=71), which were not diabetic. Serum metabolomic profiling was performed using UPLC-MS-MS (Quantse score). HOMA and QUICKI were carried out. Serum 25(OH)D concentrations were measured by chemiluminescent immunoassay. In women with SLE, the metabolomic Quantose score significantly correlated with HOMA-IR, HOMA2-IR, and QUICKI. Although concentrations of IR metabolites were not different between SLE patients and controls, fasting plasma insulin levels were higher and insulin sensitivity lower in SLE women. Interestingly, the Quantose IR score was significantly correlated with complement C3 levels (r=0.7; p=0.001). 25 (OH)D did not correlate with any metabolite or the Quantose IR index. Quantose IR may be a useful tool for IR assessment. There was a possible correlation between the metabolomic profile and complement C3 levels. The implementation of this metabolic strategy may help develop biochemical insight into metabolic disorders in SLE.

Key words

vitamin D - systemic lupus erythematosus - insulin resistance


Publication History

Received: 24 August 2022

Accepted after revision: 13 May 2023

Accepted Manuscript online:
13 May 2023

Article published online:
10 July 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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