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Synthesis 2022; 54(11): 2561-2573
DOI: 10.1055/a-1751-1929
DOI: 10.1055/a-1751-1929
short review
Transition-Metal-Catalyzed Decarbonylative Functionalization of Phthalimides
Financial support from the National Natural Science Foundation of China (Grant Nos. 21971234, 21772194, and 21572225) is acknowledged.
Abstract
Phthalimide derivatives are prevalent in a wide array of biologically important molecules, including drugs, fungicides, and anticancer molecules. Thus, catalytic methods that directly edit the phthalimide moiety, in particular, decarbonylation and derivatization, could be strategically valuable for the modification of existing phthalimide molecular scaffolds. In recent years, considerable efforts have been devoted to emulating the transition-metal-catalyzed phthalimide decarbonylative reaction. A set of elegant strategies, including decarbonylative addition reactions with alkynes, alkenes, and benzynes, decarbonylative polymerization, alkylation, arylation, and protodecarbonylation, have been demonstrated. This review aims to highlight these advances and discusses the mechanism issues, to further expand application and promote developments in this field.
1 Introduction
2 Decarbonylative Addition Reaction with Alkynes
3 Decarbonylative Addition Reaction with Alkenes
4 Decarbonylative Addition Reaction with Benzyne
5 Decarbonylative Polymerization
6 Decarbonylative Alkylation
7 Decarbonylative Arylation
8 Protodecarbonylation
9 Conclusion and Outlook
Key words
decarbonylation reactions - phthalimides - amides - C–N bond activation - isoquinolones - alkynes - alkenesPublikationsverlauf
Eingereicht: 28. Dezember 2021
Angenommen nach Revision: 26. Januar 2022
Accepted Manuscript online:
26. Januar 2022
Artikel online veröffentlicht:
17. März 2022
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