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DOI: 10.1055/a-1729-9664
Enantioselective C–H Functionalization toward Silicon-Stereogenic Silanes
We are grateful for financial support from the National Natural Science Foundation of China (21901104, 22122102, 22101120), Guangdong Provincial Key Laboratory of Catalysis (2020B121201002), and the Stable Support Plan Program of Shenzhen Natural Science Fund (Program Contract No. 20200925152450004).
Abstract
In recent years, transition-metal-catalyzed enantioselective C–H bond functionalization has emerged as a powerful and attractive synthetic approach to access silicon-stereogenic centers, which provides impetus for the innovation of chiral organosilicon chemistry. This short review summarizes recent advances in the construction of silicon-stereogenic silanes via transition-metal-catalyzed enantioselective C–H functionalization. We endeavor to highlight the great potential of this methodology and hope that this review will shed light on new perspectives and inspire further research in this emerging area.
1 Introduction
2 Enantioselective C–H Functionalization Induced by Oxidative Addition of an Aryl-OTf Bond
3 Enantioselective C–H Functionalization Induced by Oxidative Addition of a Silacyclobutane
4 Directing-Group-Assisted Enantioselective C–H Functionalization
5 Enantioselective Dehydrogenative C–H/Si–H Coupling
5.1 Enantioselective C(sp2)–H Silylation
5.2 Enantioselective C(sp3)–H Silylation
6 Summary and Outlook
Key words
asymmetric catalysis - enantioselective C–H functionalization - silicon-stereogenic silanes - C–H silylation - organosilicon compoundsPublication History
Received: 07 December 2021
Accepted after revision: 03 January 2022
Accepted Manuscript online:
03 January 2022
Article published online:
15 February 2022
© 2022. Thieme. All rights reserved
Georg Thieme Verlag KG
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