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Synthesis 2022; 54(03): 655-657
DOI: 10.1055/a-1648-7074
DOI: 10.1055/a-1648-7074
psp
A Convenient Procedure for Sonogashira Reactions Using Propyne
This work was supported by the U.S. Department of Energy (DOE), Office of Biological and Environmental Research, Biological Systems Science Division under FWP# AL-18-380-055 to the Ames Laboratory. The Ames Laboratory is operated for the U.S. Department of Energy by Iowa State University under Contract No. DE-AC02-07CH11358.
Abstract
A modified Sonogashira coupling of aryl iodides and propyne was achieved using only two equivalents of propyne in THF from –78 °C to room temperature.
Publication History
Received: 19 August 2021
Accepted after revision: 20 September 2021
Accepted Manuscript online:
20 September 2021
Article published online:
21 October 2021
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