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Synthesis 2022; 54(03): 655-657
DOI: 10.1055/a-1648-7074
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A Convenient Procedure for Sonogashira Reactions Using Propyne

Joshua L. Alterman
,
George A. Kraus∗
This work was supported by the U.S. Department of Energy (DOE), Office of Biological and Environmental Research, Biological Systems Science Division under FWP# AL-18-380-055 to the Ames Laboratory. The Ames Laboratory is operated for the U.S. Department of Energy by Iowa State University under Contract No. DE-AC02-07CH11358.
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Abstract

A modified Sonogashira coupling of aryl iodides and propyne­ was achieved using only two equivalents of propyne in THF from –78 °C to room temperature.

Key words

Sonogashira - cross coupling - propyne - ozonolysis - benzofuranone


Publication History

Received: 19 August 2021

Accepted after revision: 20 September 2021

Accepted Manuscript online:
20 September 2021

Article published online:
21 October 2021

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