Klinische Studie zur Akutwirkung eines Phytopharmakons mit D-Campher und Crataegus auf Blutdruck und kognitive Funktionen

Zusammenfassung

In einer randomisierten doppelblinden placebokontrollierten klinischen Studie wurde untersucht, ob bei einer mäßigen Hypotonie eine medikamentöse Erhöhung des Blutdrucks mit einer Steigerung der kognitiven Leistung einhergeht. 120 Erwachsene mit einem systolischen Blutdruck von unter 119 mmHg (Männer) bzw. unter 111 mmHg (Frauen) nahmen teil. Sie erhielten entweder eine Campher-Weißdorn-Kombination als Verum (N=60) oder ein Placebo (N=60). Im Vergleich zur Placebogruppe kam es in der Verumgruppe zu einem signifikant höheren Anstieg des systolischen und mittleren arteriellen Blutdrucks sowie zu einer signifikant besseren Konzentrationsleistung und einer nahezu signifikant besseren selektiven Aufmerksamkeit. Die gute Verträglichkeit und die hohe Sicherheit des Phytopharmakons wurden konstatiert.

Abstract

A randomized, placebo-controlled clinical trial was conducted to determine whether a drug-induced increase in blood pressure is associated with an increase in cognitive performance in moderate hypotension. 120 adults with a systolic blood pressure below 119 mmHg (men) or below 111 mmHg (women) participated. They received either a camphor-hawthorn combination as verum (N=60) or a placebo (N=60). Compared to the placebo group, the verum group experienced significantly higher increases in systolic and mean arterial blood pressure, as well as a significantly better concentration performance and an almost significantly better selective attention. The good tolerability and safety of the phytopharmaceutical were confirmed.

Schlüsselwörter

Klinische RCT-Studie - Hypotonie - Kognition - Campher-Weißdorn-Phytopharmakon - Sicherheit

Key words

Clinical RCT study - camphor hawthorn phytopharmaceutical - hypotension - cognition - safety

Publication History

Article published online:
16 March 2023

• Literatur

• 1 Eftekhari H, Uretsky S, Messerli FH. Blood pressure, cognitive dysfunction, and dementia. J Am Soc Hypertens 2007; 1: 135-144 DOI: 10.1016/j.jash.2007.01.003.
• 2 Hestad K, Engedal K, Schirmer H, Strand BH. The effect of blood pressure on cognitive performance. An 8-year follow-up of the Tromso Study, comprising people aged 45–74 Years. Front Psychol 2020; 11: 607 DOI: 10.3389/fpsyg.2020.00607.
• 3 Bohannon AD, Fillenbaum GG, Pieper CF. et al. Relationship of race/ethnicity and blood pressure to change in cognitive function. J Am Geriatr Soc 2002; 50: 424-429 DOI: 10.1046/j.1532-5415.2002.50104.x.
• 4 Hebert LE, Scherr PA, Bennett DA. et al. Blood pressure and late-life cognitive function change: a biracial longitudinal population study. Neurology 2004; 62: 2021-2024 DOI: 10.1212/01.wnl.0000129258.93137.4b.
• 5 Duschek S, Schandry R. Cognitive performance and cerebral blood flow in essential hypotension. Psychophysiology 2004; 41: 905-913 DOI: 10.1111/j.1469-8986.2004.00249.x.
• 6 Costa M, Stegagno L, Schandry R, Bitti PER. Contingent negative variation and cognitive performance in hypotension. Psychophysiology 1998; 35: 737-744 DOI: 10.1017/S0048577298971256.
• 7 Balijepalli C, Losch C, Bramlage P. et al. Percentile distribution of blood pressure readings in 35683 men and women aged 18 to 99 years. J Hum Hypertens 2014; 28: 193-200 DOI: 10.1038/jhh.2013.85.
• 8 Robert Koch-Institut, Abteilung für Epidemiologie und Gesundheitsmonitoring. Studie zur Gesundheit Erwachsener in Deutschland (DEGS1). Scientific Use File 1. Version. 2015. https://doi.org/10.7797/16-200812-1-1-1
• 9 Duschek S, Weisz N, Schandry R. Reduced cognitive performance and prolonged reaction time accompany moderate hypotension. Clin Auton Res 2003; 13: 427-432 DOI: 10.1007/s10286-003-0124-4.
• 10 Brickenkamp R. Test d2, Aufmerksamkeits-Belastungs-Test. Göttingen: Hogrefe; 1994
• 11 Erfurt L, Schandry R, Rubenbauer S, Braun U. The effects of repeated administration of camphor-crataegus berry extract combination on blood pressure and on attentional performance - a randomized, placebo-controlled, double-blind study. Phytomedicine 2014; 21: 1349-1355 DOI: 10.1016/j.phymed.2014.06.014.
• 12 Schandry R, Duschek S. The effect of Camphor-Crataegus berry extract combination on blood pressure and mental functions in chronic hypotension - A randomized placebo controlled double blind design. Phytomedicine 2008; 15: 914-922 DOI: 10.1016/j.phymed.2008.09.002.
• 13 Werner NS, Duschek S, Schandry R. D-camphor-crataegus berry extract combination increases blood pressure and cognitive functioning in the elderly - a randomized, placebo controlled double blind study. Phytomedicine 2009; 16: 1077-1082 DOI: 10.1016/j.phymed.2009.05.006.
• 14 Csupor D, Viczian R, Lantos T. et al. The combination of hawthorn extract and camphor significantly increases blood pressure: A meta-analysis and systematic review. Phytomedicine 2019; 63: 152984 DOI: 10.1016/j.phymed.2019.152984.
• 15 Wechsler D. Adult Intelligence Scale - Revised. New York. 1981
• 16 Guo Z, Qiu C, Viitanen M. et al. Blood pressure and dementia in persons 75+ years old: 3-year follow-up results from the Kungsholmen Project. J Alzheimers Dis 2001; 3: 585-591 DOI: 10.1093/oxfordjournals.aje.a009073.
• 17 Schandry R, Lindauer D, Mauz M. Blood pressure and cognitive performance after a single administration of a Camphor-Crataegus combination in adolescents with low blood pressure. Planta Med 2018; 84: 1249-1254 DOI: 10.1055/a-0634-6597.
• 18 Belz GG, Butzer R, Gaus W, Loew D. Camphor-Crataegus berry extract combination dose-dependently reduces tilt induced fall in blood pressure in orthostatic hypotension. Phytomedicine 2002; 9: 581-588 DOI: 10.1078/094471102321616382.
• 19 Alaoui-Ismaili O, Vernet-Maury E, Dittmar A. et al. Odor hedonics: connection with emotional response estimated by autonomic parameters. Chem Senses 1997; 22: 237-248 DOI: 10.1093/chemse/22.3.237.
• 20 Lagoni N, Mauz M. Wetterfühligkeit und Wohlbefinden, Interventionen bei Kreislauflabilität. Erfahrungsheilkunde 2008; 57: 670-675 DOI: 10.1055/s-0028-1082621
• 21 Park TJ, Seo HK, Kang BJ, Kim KT. Noncompetitive inhibition by camphor of nicotinic acetylcholine receptors. Biochem Pharmacol 2001; 61: 787-793 DOI: 10.1016/s0006-2952(01)00547-0.
• 22 Duschek S, Schandry R. Reduced brain perfusion and cognitive performance due to constitutional hypotension. Clin Auton Res 2007; 17: 69-76 DOI: 10.1007/s10286-006-0379-7.
• 23 Reitan RM. Validity of the trail making test as an indicator of organic brain damage. Percept Mot Skills 1958; 8: 271-276 DOI: 10.2466/pms.1958.8.3.271.