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Int J Sports Med 2021; 42(10): 889-895
DOI: 10.1055/a-1332-1594
Physiology & Biochemistry

Age-related Decline in Renal Function is Attenuated in Master Athletes

Thiago dos Santos Rosa 
Graduate Program on Physical Education and Health, Catholic University of Brasilia, Taguatinga, Brazil.
,
Hugo Luca Corrêa
Graduate Program on Physical Education and Health, Catholic University of Brasilia, Taguatinga, Brazil.
,
Lucas Pinheiro Barbosa
Graduate Program on Physical Education and Health, Catholic University of Brasilia, Taguatinga, Brazil.
,
Patrick Anderson dos Santos
Graduate Program on Physical Education and Health, Catholic University of Brasilia, Taguatinga, Brazil.
,
Patrício Lopes de Araújo Leite
Graduate Program on Physical Education and Health, Catholic University of Brasilia, Taguatinga, Brazil.
,
Samuel Silva Aguiar 
Graduate Program on Physical Education and Health, Catholic University of Brasilia, Taguatinga, Brazil.
,
Lysleine Alves Deus 
Graduate Program on Physical Education and Health, Catholic University of Brasilia, Taguatinga, Brazil.
,
Larissa Alves Maciel
Graduate Program on Physical Education and Health, Catholic University of Brasilia, Taguatinga, Brazil.
,
Rodrigo Vanerson Passos Neves
Graduate Program on Physical Education and Health, Catholic University of Brasilia, Taguatinga, Brazil.
,
Herbert Gustavo Simoes
Graduate Program on Physical Education and Health, Catholic University of Brasilia, Taguatinga, Brazil.
› Author Affiliations Funding: We want to thank all individuals that agreed to participate of the study and the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior for partially fund our study.
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Abstract

This study analyzed the kidney function and biomarkers of health in lifelong-trained sprinters and endurance runners, and compared them to untrained aged-matched and young controls. Sixty-two men (21–66 yr.) were recruited and allocated as master athletes from sprints (n=25), master athletes from endurance events (n=8), untrained middle-aged (n=14) and young controls (n=15). Participants underwent anamnesis, anthropometric measures and blood sampling for biochemical analyses of klotho, FGF23 and estimated glomerular filtration rate. Master sprinters presented better kidney function in relation to endurance athletes and their untrained peers (P<0.0001). A number of biochemical variables were observed that negatively (i. e., GDF-15, TGF-Beta, IL-18) or positively (i. e., klotho/FGF23 ratio and sestrin-2) correlated with eGFR. Sestrin-2 presented the strongest association with eGFR (r=0.5, P=0.03). Results also revealed that lifelong-trained individuals presented the highest probability of having better values for cystatin C and thus an estimated glomerular filtration rate that was 37–49% higher than untrained peers. Master sprinters presented better kidney function in relation to endurance athletes and middle-aged untrained peers. Sestrin-2 may play a role in exercise-induced kidney function protection.

Key words

klotho - sestrin - FGF-23 - inflammation - oxidative stress - runners


Publication History

Received: 04 June 2020

Accepted: 25 November 2020

Article published online:
08 March 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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