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Synlett 2021; 32(03): 326-328
DOI: 10.1055/a-1275-2848
DOI: 10.1055/a-1275-2848
letter
A Concise Route to MK-4482 (EIDD-2801) from Cytidine: Part 2
We thank the Bill and Melinda Gates Foundation (OPP1176590) for their longstanding support of our research.


Abstract
A new route to MK-4482 was developed. The route replaces uridine with the more available and less expensive cytidine. Low-cost, simple reagents are used for the chemical transformations, and the yield is improved from 17% to 44%. A step is removed from the longest linear sequence, and these advancements are expected to expand access to MK-4482 should it become a viable drug substance.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1275-2848.
- Supporting Information
Publication History
Received: 10 September 2020
Accepted after revision: 30 September 2020
Accepted Manuscript online:
30 September 2020
Article published online:
30 October 2020
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