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Klin Monbl Augenheilkd 2019; 236(09): 1068-1075
DOI: 10.1055/a-0958-9621
Übersicht
Georg Thieme Verlag KG Stuttgart · New York

Trockene altersabhängige Makuladegeneration – Epidemiologie und Klassifikation

Dry Age-Related Macular Degeneration – Epidemiology and Classification
Monika Fleckenstein
1   Universitäts-Augenklinik, Universitätsklinikum Bonn
2   John A. Moran Eye Center, University of Utah, Salt Lake City, United States
,
Sarah Thiele
1   Universitäts-Augenklinik, Universitätsklinikum Bonn
,
Maximilian Pfau
1   Universitäts-Augenklinik, Universitätsklinikum Bonn
,
Steffen Schmitz-Valckenberg
1   Universitäts-Augenklinik, Universitätsklinikum Bonn
,
Frank G. Holz
1   Universitäts-Augenklinik, Universitätsklinikum Bonn
› Author Affiliations
Further Information

Publication History

eingereicht 13 April 2019

akzeptiert 04 June 2019

Publication Date:
11 September 2019 (online)

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Zusammenfassung

Klinisch wird die altersabhängige Makuladegeneration (AMD) in Früh- und Spätstadien eingeteilt. Der Begriff „trockene“ AMD wird häufig verwendet, wenn keine „exsudativen“ Veränderungen am Augenhintergrund vorliegen. Es existiert eine Vielzahl von Studien zur Epidemiologie der AMD. Dabei wird in den meisten Studien zwischen AMD-Früh- und -Spätformen unterschieden, allerdings ohne eine weitere Differenzierung der „trockenen“ AMD-Spätform. Zudem stellt sich die Herausforderung unterschiedlicher Klassifikationen der AMD in verschiedenen Studien, was zwangsläufig zu Abweichungen in den epidemiologischen Daten bei der AMD führt. Neue Klassifikationssysteme berücksichtigen mikrostrukturelle Veränderungen, die mittels hochauflösender In-vivo-Bildgebung der Netzhaut detektiert werden können. Eine neue Konsensusklassifikation der AMD-assoziierten Atrophie soll ermöglichen, zukünftige Studien nach einheitlichen Definitionen durchzuführen.

Abstract

Age-related macular degeneration (AMD) is clinically divided into early and late stages. The term “dry” AMD is widely used when there are no “exudative” changes in the ocular fundus. There are numerous studies on the epidemiology of AMD. Most studies differentiate between early and late forms of AMD, but without further differentiation of the “dry” late form. In addition, different studies may employ different classifications of AMD, which inevitably leads to deviations in epidemiological data on AMD. New classification systems take into account microstructural changes that can be detected by high resolution in vivo imaging of the retina. A new consensus classification of AMD-associated atrophy will allow future studies to be conducted according to uniform definitions.

Schlüsselwörter

altersabhängige Makuladegeneration - AMD - Epidemiologie - Klassifikation

Key words

age-related macular degeneration - AMD - epidemiology - classification
 

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