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DOI: 10.1055/a-0929-6287
Moderate Consumption of Red Meat, Compared to Soy or Non-Soy Legume, Has No Adverse Effect on Cardio-Metabolic Factors in Patients with Type 2 Diabetes
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Abstract
Background Recently, it has been proposed that red meat consumption could enhance risk of diabetes and worsen lipid profile and glycemic status, in comparison with soy or non-soy legume, but the results of clinical trials are controversial.
Objectives This study aimed to compare the effect of red meat, soy bean, and non-soy legume consumption on cardio-metabolic factors in patients with type 2 diabetes.
Methods This was a randomized controlled clinical trial which included 75 patients with diabetes, aged 40–65 years. Participants were randomly allocated to receive two servings of red meat (control group), soy bean, or non-soy legume, 3 days a week for 8 weeks. All groups also received a balanced-macronutrients weight maintenance diet. Body composition and cardio-metabolic factors including fasting blood glucose (FBG), fasting insulin, glycated hemoglobin (HbA1c), serum lipids, and blood pressure were measured at baseline and endpoint of the study. Quantitative insulin sensitivity check index (QUICKI) score and Framingham risk score (FRS) were also computed.
Results We found no significant differences in changes of FBG, fasting insulin, HbA1c, QUICKI score, serum lipids, FRS, and systolic and diastolic blood pressure among the 3 groups. Within group analysis showed that FRS reduced significantly in all groups (P<0.05). In addition, systolic (P=0.01) and diastolic (P=0.03) blood pressure reduced within red meat group.
Conclusions Compared to soy bean or non-soy legume, moderate consumption of red meat had no adverse effect on cardio-metabolic factors including FBG, fasting insulin, HbA1C, QUICKI score, total cholesterol, low-density lipoprotein , high-density lipoprotein , and blood pressure in adults with type 2 diabetes.
Publication History
Received: 08 March 2019
Received: 30 April 2019
Accepted: 21 May 2019
Article published online:
17 June 2019
© 2019. Thieme. All rights reserved.
© Georg Thieme Verlag KG
Stuttgart · New York
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References
- 1 De Rosa S, Arcidiacono B, Chiefari E. et al. Type 2 diabetes mellitus and cardiovascular disease: genetic and epigenetic links. Front Endocrinol (Lausanne) 2018; 9: 2
- 2 Chawla A, Chawla R, Jaggi S. Microvasular and macrovascular complications in diabetes mellitus: Distinct or continuum?. Indian J Endocrinol Metab 2016; 20: 546-551
- 3 Cho NH, Shaw JE, Karuranga S. et al. IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract 2018; 138: 271-81.
- 4 American Diabetes Association. Lifestyle Management: Standards of Medical Care in Diabetes—2019. Diabetes Care 2019; 42 (Supplement 1) S46-S60
- 5 Meyer KA, Kushi LH, Jacobs DR. et al. Carbohydrates, dietary fiber, and incident type 2 diabetes in older women. Am J Clin Nutr 2000; 71: 921-30.
- 6 Villegas R, Gao YT, Yang G. et al. Legume and soy food intake and the incidence of type 2 diabetes in the Shanghai Women’s Health Study. Am J Clin Nutr 2008; 87: 162-167
- 7 Mueller NT, Odegaard AO, Gross MD. et al. Soy intake and risk of type 2 diabetes in Chinese Singaporeans [corrected]. Eur J Nutr 2012; 51: 1033-40.
- 8 Kwon DY, Daily 3rd JW, Kim HJ. et al. Antidiabetic effects of fermented soybean products on type 2 diabetes. Nutr Res 2010; 30: 1-13
- 9 Jenkins DJ, Wolever TM, Buckley G. et al. Low-glycemic-index starchy foods in the diabetic diet. Am J Clin Nutr 1988; 48: 248-54.
- 10 Fung TT, Schulze M, Manson JE. et al. Dietary patterns, meat intake, and the risk of type 2 diabetes in women. Arch Intern Med 2004; 164: 2235-2240
- 11 Vang A, Singh PN, Lee JW. et al. Meats, processed meats, obesity, weight gain and occurrence of diabetes among adults: Findings from Adventist Health Studies. Ann Nutr Metab 2008; 52: 96-104
- 12 Tucker LA, LeCheminant JD, Bailey BW. Meat intake and insulin resistance in women without type 2 diabetes. Journal of Diabetes Research 2015; 2015: 174742
- 13 Chai W, Morimoto Y, Cooney RV. et al. Dietary red and processed meat intake and markers of adiposity and inflammation: The multiethnic cohort study. J Am Coll Nutr 2017; 36: 378-85.
- 14 Maron DJ, Fair JM, Haskell WL. Saturated fat intake and insulin resistance in men with coronary artery disease. The Stanford Coronary Risk Intervention Project Investigators and Staff. Circulation 1991; 84: 2020-2027
- 15 Hosseinpour-Niazi S, Mirmiran P, Hedayati M. et al. Substitution of red meat with legumes in the therapeutic lifestyle change diet based on dietary advice improves cardiometabolic risk factors in overweight type 2 diabetes patients: a cross-over randomized clinical trial. Eur J Clin Nutr 2015; 69: 592-597
- 16 Yang B, Chen Y, Xu T. et al. Systematic review and meta-analysis of soy products consumption in patients with type 2 diabetes mellitus. Asia Pac J Clin Nutr 2011; 20: 593-602
- 17 Zhang XM, Zhang YB, Chi MH. Soy Protein Supplementation Reduces Clinical Indices in Type 2 Diabetes and Metabolic Syndrome. Yonsei Med J 2016; 57: 681-689
- 18 Anderson JW, Bush HM. Soy protein effects on serum lipoproteins: A quality assessment and meta-analysis of randomized, controlled studies. J Am Coll Nutr 2011; 30: 79-91
- 19 Liu ZM, Chen YM, Ho SC. Effects of soy intake on glycemic control: A meta-analysis of randomized controlled trials. Am J Clin Nutr 2011; 93: 1092-101.
- 20 Shidfar F, Ehrampoush E, Heydari I. et al. The effects of soy bean on serum homocysteine, Lp(a) and lipoproteins in hyperlipidemic postmenopausal women. IJEM 2008; 10: 345-352
- 21 Pearson D, Grace C. Weight Management: A Practitioner’s Guide. First Edition Blackwell Publishing Ltd; 2012
- 22 Craig CL, Marshall AL, Sjöström M. et al. International physical activity questionnaire: 12-country reliability and validity. Medicine and science in sports and exercise 2003; 35: 1381-95.
- 23 Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). Jama 2001; 285: 2486-97.
- 24 Kim Y, Keogh JB, Clifton PM. Consumption of red and processed meat and refined grains for 4 weeks decreases insulin sensitivity in insulin-resistant adults: A randomized crossover study. Metabolism 2017; 68: 173-83.
- 25 White DL, Collinson A. Red meat, dietary heme iron, and risk of type 2 diabetes: the involvement of advanced lipoxidation endproducts. Advances in nutrition (Bethesda, Md.) 2013; 4: 403-411
- 26 Fretts AM, Howard BV, McKnight B. et al. Associations of processed meat and unprocessed red meat intake with incident diabetes: The Strong Heart Family Study. Am J Clin Nutr 2012; 95: 752-758
- 27 Pan A, Sun Q, Bernstein AM. et al. Red meat consumption and risk of type 2 diabetes: 3 cohorts of US adults and an updated meta-analysis. Am J Clin Nutr 2011; 94: 1088-96.
- 28 Sievenpiper JL, Kendall CW, Esfahani A. et al. Effect of non-oil-seed pulses on glycaemic control: a systematic review and meta-analysis of randomised controlled experimental trials in people with and without diabetes. Diabetologia 2009; 52: 1479-95.
- 29 Hartman TJ, Albert PS, Zhang Z. et al. Consumption of a legume-enriched, low-glycemic index diet is associated with biomarkers of insulin resistance and inflammation among men at risk for colorectal cancer. J Nutr 2010; 140: 60-67
- 30 Montonen J, Boeing H, Fritsche A. et al. Consumption of red meat and whole-grain bread in relation to biomarkers of obesity, inflammation, glucose metabolism and oxidative stress. Eur J Nutr 2013; 52: 337-45.
- 31 Ley SH, Sun Q, Willett WC. et al. Associations between red meat intake and biomarkers of inflammation and glucose metabolism in women. Am J Clin Nutr 2014; 99: 352-60.
- 32 Barak F, Falahi E, Keshteli AH. et al. Red meat intake, insulin resistance, and markers of endothelial function among Iranian women. Mol Nutr Food Res 2015; 59: 315-22.
- 33 Dal S, Sigrist S. The protective effect of antioxidants consumption on diabetes and vascular complications. Diseases (Basel, Switzerland) 2016; 4: 24
- 34 Vega-Lopez S, Yeum KJ, Lecker JL. et al. Plasma antioxidant capacity in response to diets high in soy or animal protein with or without isoflavones. Am J Clin Nutr 2005; 81: 43-49
- 35 Saraf-Bank S, Esmaillzadeh A, Faghihimani E. et al. Effects of legume-enriched diet on cardiometabolic risk factors among individuals at risk for diabetes: A crossover study. J Am Coll Nutr 2016; 35: 31-40
- 36 Hermsdorff HH, Zulet MA, Abete I. et al. A legume-based hypocaloric diet reduces proinflammatory status and improves metabolic features in overweight/obese subjects. Eur J Nutr 2011; 50: 61-69
- 37 Zahradka P, Wright B, Weighell W. et al. Daily non-soy legume consumption reverses vascular impairment due to peripheral artery disease. Atherosclerosis 2013; 230: 310-314
- 38 Abete I, Parra D, Martinez JA. Legume-, fish-, or high-protein-based hypocaloric diets: Effects on weight loss and mitochondrial oxidation in obese men. J Med Food 2009; 12: 100-108
- 39 Tovar J, Nilsson A, Johansson M. et al. Combining functional features of whole-grain barley and legumes for dietary reduction of cardiometabolic risk: A randomised cross-over intervention in mature women. Br J Nutr 2014; 111: 706-14.
- 40 Clerici C, Nardi E, Battezzati PM. et al. Novel soy germ pasta improves endothelial function, blood pressure, and oxidative stress in patients with type 2 diabetes. Diabetes Care 2011; 34: 1946-1948
- 41 Wong WW, Taylor AA, Smith EO. et al. Effect of soy isoflavone supplementation on nitric oxide metabolism and blood pressure in menopausal women. Am J Clin Nutr 2012; 95: 1487-94.
- 42 Mohammadifard N, Salehi-Abargouei A, Salas-Salvado J. et al. The effect of tree nut, peanut, and soy nut consumption on blood pressure: A systematic review and meta-analysis of randomized controlled clinical trials. Am J Clin Nutr 2015; 101: 966-82.
- 43 Altorf-van der Kuil W, Engberink MF, Brink EJ. et al. Dietary protein and blood pressure: A systematic review. PLoS One 2010; 5: e12102
- 44 Dong J-Y, Tong X, Wu Z-W. et al. Effect of soya protein on blood pressure: A meta-analysis of randomised controlled trials. British Journal of Nutrition 2011; 106: 317-26.
- 45 Liu XX, Li SH, Chen JZ. et al. Effect of soy isoflavones on blood pressure: A meta-analysis of randomized controlled trials. Nutr Metab Cardiovasc Dis 2012; 22: 463-70.