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DOI: 10.1055/a-0761-1891
Oxidativer Stress im Sport – ein Fall für Antioxidanzien!?
Publication History
Publication Date:
04 February 2019 (online)
Zusammenfassung
Bei intensiver körperlicher Anstrengung kann es zur Überproduktion von reaktiven Sauerstoff- und Stickstoffverbindungen und damit zu oxidativem Stress kommen. Neben potenziell schädlicher Wirkung auf körpereigene Strukturen haben freie Radikale auch physiologische Aufgaben, u. a. im Rahmen der Infektabwehr, bei der kontraktilen Funktion des Skelettmuskels sowie bei mitochondrialer und vaskulärer Adaptation. Moderates sportliches Training erhöht Konzentration und Aktivität körpereigener antioxidativer Schutzsysteme, sodass trainierte Sportler eine höhere Resistenz gegen oxidativen Stress besitzen. Breitensportler können ihren Bedarf an Antioxidanzien über eine angepasste Ernährung decken, während bei Spitzensportlern in intensiven Trainings- und Wettkampfphasen eine temporäre, laborkontrollierte Supplementierung empfohlen werden kann. Neben Vitamin C kommt bei Leistungssportlern dem Coenzym Q10 eine besondere Bedeutung zu.
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Literatur
- 1 Alessio HM. Exercise-induced oxidative stress. Med Sci Sports Exerc 1993; 25 (02) : 218-224
- 2 Alessio HM, Hagerman AE, Fulkerson BK. et al. Generation of reactive oxygen species after exhaustive aerobic and isometric exercise. Med Sci Sports Exerc 2000; 32 (09) : 1576-1581
- 3 Saxton JM, Donnelly AE, Roper HP. Indices of free-radical-mediated damage following maximum voluntary eccentric and concentric muscular work. Eur J Appl Physiol Occup Physiol 1994; 68 (03) : 189-193
- 4 Wilber RL, Holm PL, Morris DM. et al. Effect of FIO2 on oxidative stress during interval training at moderate altitude. Med Sci Sports Exerc 2004; 36 (11) : 1888-1894
- 5 Halliwell B. Cell culture, oxidative stress, and antioxidants: avoiding pitfalls. Biomed J 2014; 37 (03) : 99-105
- 6 Powers SK, Nelson WB, Hudson MB. Exercise-induced oxidative stress in humans: cause and consequences. Free Radic Biol Med 2011; 51 (05) : 942-950
- 7 Gomez-Cabrera MC, Domenech E, Romagnoli M. et al. Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. Am J Clin Nutr 2008; 87 (01) : 142-149
- 8 Finaud J, Lac G, Filaire E. Oxidative stress: relationship with exercise and training. Sports Med 2006; 36 (04) : 327-358
- 9 Dékány M, Nemeskéri V, Györe I. et al. Antioxidant status of interval-trained athletes in various sports. Int J Sports Med 2006; 27 (02) : 112-116
- 10 Nikolaidis MG, Kyparos A, Spanou C. et al. Redox biology of exercise: An integrative and comparative consideration of some overlooked issues. J Exp Biol 2012; 215 (Pt 10): 1615-1625
- 11 Peters EM, Goetzsche JM, Grobbelaar B, Noakes TD. Vitamin C supplementation reduces the incidence of postrace symptoms of upper-respiratory-tract infection in ultramarathon runners. Am J Clin Nutr 1993; 57 (02) : 170-174
- 12 Kuipers H. Exercise-induced muscle damage. Int J Sports Med 1994; 15 (03) : 132-135
- 13 Powers SK, Nelson WB, Hudson MB. Exercise-induced oxidative stress in humans: cause and consequences. Free Radic Biol Med 2011; 51 (05) : 942-950
- 14 Lamprecht M. Oxidativer Stress und Antioxidantien beim sportlichen Training. JEM 2010; 12 (03) : 6-12
- 15 Vollaard NB, Shearman JP, Cooper CE. Exercise-induced oxidative stress: myths, realities and physiological relevance. Sports Med 2005; 35 (12) : 1045-1062
- 16 Cooper CE, Vollaard NB, Choueiri T, Wilson MT. Exercise, free radicals and oxidative stress. Biochem Soc Trans 2002; 30 (02) : 280-285
- 17 Rush JW, Sandiford SD. Plasma glutathione peroxidase in healthy young adults: influence of gender and physical activity. Clin Biochem 2003; 36 (05) : 345-351
- 18 Radak Z, Taylor AW, Ohno H, Goto S. Adaptation to exercise-induced oxidative stress: from muscle to brain. Exerc Immunol Rev 2001; 7: 90-107
- 19 Gomez-Cabrera MC, Domenech E, Viña J. Moderate exercise is an antioxidant: upregulation of antioxidant genes by training. Free Radic Biol Med 2008; 44 (02) : 126-131
- 20 Spangenburg EE. Suppressor of cytokine signaling, skeletal muscle, and chronic health conditions: the potential interactions. Exerc Sport Sci Rev 2007; 35 (03) : 156-162
- 21 Lamprecht M, Oettl K, Schwaberger G. et al. Protein modification responds to exercise intensity and antioxidant supplementation. Med Sci Sports Exerc 2009; 41 (01) : 155-163
- 22 Deutscher Olympischer Sportbund (DOSB). Nahrungsergänzungmittel. 2014 . Im Internet: https: / /cdn.dosb.de/alter_Datenbestand/fm-dosb/arbeitsfelder/leistungssport/Konzepte/NEM_Broschuere-web_14-7-2014_Doppelseitig.pdf
- 23 Ranchordas MK, Rogerson D, Soltani H, Costello JT. Antioxidants for preventing and reducing muscle soreness after exercise. Cochrane Database Syst Rev. 2017; 12: CD009789 . doi: 10.1002/14651858.CD009789.pub2
- 24 Paschalis V, Theodorou AA, Margaritelis NV. et al. N-acetylcysteine supplementation increases exercise performance and reduces oxidative stress only in individuals with low levels of glutathione. Free Radic Biol Med 2018; 115: 288-297
- 25 Ristow M, Zarse K, Oberbach A. et al. Antioxidants prevent health-promoting effects of physical exercise in humans. Proc Natl Acad Sci U S A 2009; 106: 8665-8670
- 26 Powers SK, Nelson WB, Hudson MB. Exercise-induced oxidative stress in humans: cause and consequences. Free Radic Biol Med 2011; 51 (05) : 942-950
- 27 Gomez-Cabrera MC, Domenech E, Romagnoli M. et al. Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. Am J Clin Nutr 2008; 87 (01) : 142-149
- 28 Finaud J, Lac G, Filaire E. Oxidative stress: relationship with exercise and training. Sports Med 2006; 36 (04) : 327-358
- 29 Dékány M, Nemeskéri V, Györe I. et al. Antioxidant status of interval-trained athletes in various sports. Int J Sports Med 2006; 27 (02) : 112-116
- 30 Nikolaidis MG, Kyparos A, Spanou C. et al. Redox biology of exercise: An integrative and comparative consideration of some overlooked issues. J Exp Biol 2012; 215 (Pt 10): 1615-1625
- 31 Peters EM, Goetzsche JM, Grobbelaar B, Noakes TD. Vitamin C supplementation reduces the incidence of postrace symptoms of upper-respiratory-tract infection in ultramarathon runners. Am J Clin Nutr 1993; 57 (02) : 170-174
- 32 Frei B, Birlouez-Aragon I, Lykkesfeldt J. Authors’ perspective: What is the optimum intake of vitamin C in humans? Crit Rev Food Sci 2012; 52 (09) : 815-829
- 33 Carr AC, Bozonet SM, Pullar JM. et al. Human skeletal muscle ascorbate is highly responsive to changes in vitamin C intake and plasma concentrations. Am J Clin Nutr 2013; 97 (04) : 800-807
- 34 Wray DW, Uberoi A, Lawrenson L. et al. Oral antioxidants and cardiovascular health in the exercise-trained and untrained elderly: A radically different outcome. Clin Sci (Lond) 2009; 116: 433-441
- 35 Yfanti C, Akerstrom T, Nielsen S. et al. Antioxidant supplementation does not alter endurance training adaptation. Med Sci Sports Exerc 2010; 42: 1388-1395
- 36 Hemilä H. Vitamin C should be tested against exercise-induced bronchoconstriction. Am J Respir Crit Care Med 2013; 188 (11) : 1370 . doi: 10.1164/rccm.201307-1205LE
- 37 Hemilä H. Vitamin C may alleviate exercise-induced bronchoconstriction: a meta-analysis. BMJ Open 2013; 3 (06) .pii: e002416 . doi: 10.1136/bmjopen-2012-002416
- 38 Peters EM, Goetzsche JM, Grobbelaar B, Noakes TD. Vitamin C supplementation reduces the incidence of postrace symptoms of upper-respiratory-tract infection in ultramarathon runners. Am J Clin Nutr 1993; 57 (02) : 170-174
- 39 Paschalis V, Theodorou AA, Kyparos A. et al. Low vitamin C values are linked with decreased physical performance and increased oxidative stress: reversal by vitamin C supplementation. Eur J Nutr 2016; 55 (01) : 45-53
- 40 McLeay Y, Stannard S, Barnes M. The Effect of Taurine on the Recovery from Eccentric Exercise-Induced Muscle Damage in Males. Antioxidants (Basel) 2017; 6 (04) ). pii: E79 . doi: 10.3390/antiox6040079
- 41 Muñoz D, Barrientos G, Alves J. et al. Oxidative stress, lipid peroxidation indexes and antioxidant vitamins in long and middle distance athletes during a sport season. J Sports Med Phys Fitness. 2017 ; doi: 10.23736/S0022-4707.17.07887-2 .
- 42 Lykkesfeldt J, Poulsen HE. Is vitamin C supplementation beneficial? Lessons learned from randomised controlled trials. Br J Nutr 2010; 103 (09) : 1251-1259
- 43 Peternelj TT, Coombes JS. Antioxidant supplementation during exercise training: beneficial or detrimental? Sports Med 2011; 41 (12) : 1043-1069
- 44 Lamprecht M. Antioxidants in Sport Nutrition. CRC Press an imprint of the Taylor & Francis Group; 2015: 203-220
- 45 Alf D, Schmidt ME, Siebrecht SC. Ubiquinol supplementation enhances peak power production in trained athletes: a double-blind, placebo controlled study. J Int Soc Sports Nutr 2013; 10: 24 . doi: 10.1186/1550-2783-10-24
- 46 Gröber U. Coenzym Q10 – der mitochondriale Blockbuster. OM – Zs f Orth Med 2018; 16: 1-4
- 47 Gröber U, Schmidt J, Kisters K. Important drug-micronutrient interactions: a selection for clinical practice. Crit Rev Food Sci Nutr 2018 [ Epub ahead of print ]
- 48 Gröber U, Kisters K, Adamietz I. Poster: Magnesium der mitochondriale Blockbuster im Leistungssport. 42. Wissenschaftlicher Kongress der deutschen Hochdruckliga, Berlin, 24.11.2018