Dtsch Med Wochenschr 2008; 133(18): 954-958
DOI: 10.1055/s-2008-1075673
Prinzip & Perspektive
Nephrologie, Molekularbiologie
© Georg Thieme Verlag KG Stuttgart · New York

Molekulare Pathogenese der Proteinurie

Molecular pathogenesis of proteinuriaT. B. Huber1
  • 1Medizinische Klinik IV, Nephrologie, Universitätsklinik Freiburg
Further Information

Publication History

eingereicht: 7.8.2007

akzeptiert: 28.1.2008

Publication Date:
23 April 2008 (online)

Literatur

  • 1 Farquhar M G, Palade G E. Glomerular permeability. II. Ferritin transfer across the glomerular capillary wall in nephrotic rats.  J Exp Med. 1961;  114 699-716
  • 2 Huber T B, Benzing T. The slit diaphragm: a signaling platform to regulate podocyte function.  Curr Opin Nephrol Hypertens. 2005;  14 211-216
  • 3 Huber T B, Hartleben B, Kim J. et al . Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling.  Mol Cell Biol. 2003;  23 4917-4928
  • 4 Huber T B, Kwoh C, Wu H. et al . Bigenic mouse models of focal segmental glomerulosclerosis involving pairwise interaction of CD2AP, Fyn, and synaptopodin.  J Clin Invest. 2006;  116 1337-1345
  • 5 Huber T B, Schermer B, Benzing T. Podocin organizes ion channel-lipid supercomplexes: implications for mechanosensation at the slit diaphragm.  Nephron Exp Nephrol. 2007;  106 e27-e31
  • 6 Huber T B, Schermer B, Muller R U. et al . Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels.  Proc Natl Acad Sci U S A. 2006;  103 17079-17086
  • 7 Huber T B, Schmidts M, Gerke P. et al . The carboxyl terminus of Neph family members binds to the PDZ domain protein zonula occludens-1.  J Biol Chem. 2003;  278 13417-13421
  • 8 Huber T B, Simons M, Hartleben B. et al . Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains.  Hum Mol Genet. 2003;  12 3397-3405
  • 9 Kestila M, Lenkkeri U, Mannikko M. et al . Positionally cloned gene for a novel glomerular protein - nephrin - is mutated in congenital nephrotic syndrome.  Mol Cell. 1998;  1 575-582
  • 10 Nagata M, Scharer K, Kriz W. Glomerular damage after uninephrectomy in young rats. I. Hypertrophy and distortion of capillary architecture.  Kidney Int. 1992;  42 136-147
  • 11 Pavenstadt H, Kriz W, Kretzler M. Cell biology of the glomerular podocyte.  Physiol Rev. 2003;  83 253-307
  • 12 Pollak M R. The genetic basis of FSGS and steroid-resistant nephrosis.  Semin Nephrol. 2003;  23 141-146
  • 13 Schlondorff J S, Pollak M R. TRPC6 in glomerular health and disease: what we know and what we believe.  Semin Cell Dev Biol. 2006;  17 667-674
  • 14 Smithies O. Why the kidney glomerulus does not clog: a gel permeation/diffusion hypothesis of renal function.  Proc Natl Acad Sci U S A. 2003;  100 4108-4113
  • 15 Wartiovaara J, Ofverstedt L G, Khoshnoodi J. et al . Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography.  J Clin Invest. 2004;  114 1475-1483
  • 16 Wiggins R C. The spectrum of podocytopathies: a unifying view of glomerular diseases.  Kidney Int. 2007;  71 1205-1214

PD Dr. med. Tobias B. Huber

Medizinische Klinik IV, Nephrologie, Universitätsklinik Freiburg

Hugstetterstraße 55

79106 Freiburg

Phone: 0761/270-3559

Fax: 0761/270-6324

Email: tobias.huber@uniklinik-freiburg.de

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