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Pharmacopsychiatry 2007; 40: S62-S72
DOI: 10.1055/s-2007-992132
DOI: 10.1055/s-2007-992132
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York
Dopamine, Prefrontal Cortex and Working Memory Functioning in Schizophrenia
E. M. Meisenzahl 1 , J. Scheuerecker 1 , G. J. S. Schmitt 1 , H. J. Möller 1Further Information
Publication History
Publication Date:
17 December 2007 (online)
Abstract
Proposing working memory disturbances as one of the core symptoms of cognitive deficits in schizophrenia the authors summarize and discuss the dependency on prefrontal cortex functioning and working memory performance. On the basis of a strong association of prefrontal functioning and the dopaminergic system the authors refer to schizophrenia as an illustrative example. Altered dopamine function and associated working memory performance are discussed with regard to effects of psychopharmacological treatment to modulate cognitive processes.
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Correspondence
E.M. Meisenzahl
Department of Psychiatry
Ludwig-Maximilians-University of Munich
Nussbaumstrasse 7
80336 Munich
Germany
Phone: +49/89/5160 57 72
Fax: +49/89/5160 34 13
Email: Eva.Meisenzahl@med.uni-muenchen.de