Delay of gratification and executive performance in individuals with schizophrenia: putative role for eating behavior and body weight regulation

Impairment in executive functions and disturbed weight regulation are common features in individuals with schizophrenia on antipsychotics. Still, the clinical management of weight gain is insufficient. Therefore, we hypothesized that distinct executive impairment is associated with the inability to self-control food intake. We investigated the performance in a paradigm analyzing the executive subfunction “delay of gratification“ (DOG) in individuals with schizophrenia (n=29) compared with controls (n=23) and the interrelationship between DOG, overall executive functioning, reported eating behavior and the BMI. We applied a board-game paradigm to operationalize DOG. Appetite and eating behavior were assessed by self-report scales, executive functioning by BADS. We found that the patients performed significantly worse in our paradigm and that this is associated with lower executive functioning. However, the interrelationship between all parameters is complex: there is a significant positive correlation between the reported perceived appetite and executive functioning whereas the reported restrained eating behavior, significantly more frequent in patients, is correlated with low executive functioning and high disinhibition in eating situations. We conclude that executive functions are necessary to successfully manage eating behavior. Thus, better understanding of the cognitive mechanisms might help to support the patients more efficiently in their tough job to keep control.