Planta Med 2007; 73(13): 1418-1420
DOI: 10.1055/s-2007-990240
Natural Product Chemistry
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic Mycoepoxydiene Derivatives from an Endophytic Fungus Phomopsis sp. Isolated from Hydnocarpus anthelminthicus

Surasak Prachya1 , 2 , Suthep Wiyakrutta3 , Nongluksna Sriubolmas4 , Nattaya Ngamrojanavanich2 , 5 , Chulabhorn Mahidol1 , 6 , Somsak Ruchirawat1 , 6 , Prasat Kittakoop1
  • 1Chulabhorn Research Institute and Chulabhorn Graduate Institute, Vipavadee-Rangsit Highway, Bangkok, Thailand
  • 2Program of Biotechnology, Faculty of Science, Chulalongkorn University, Bangkok, Thailand
  • 3Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand
  • 4Department of Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
  • 5Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand
  • 6Chulabhorn Research Centre, Institute of Science and Technology for Research and Development, Mahidol University, Thailand
Further Information

Publication History

Received: June 27, 2007 Revised: September 10, 2007

Accepted: September 12, 2007

Publication Date:
10 October 2007 (online)

Abstract

Mycoepoxydiene (1) and derivatives, deacetylmycoepoxydiene (2) and 2,3-dihydromycoepoxydiene (3), were isolated from a broth extract of the endophytic fungus, Phomopsis sp., which was isolated from a Thai medicinal plant, Hydnocarpus anthelminthicus. Compounds 1 and 2 exhibited potent cytotoxic activity, while a dihydro derivative 3 was inactive. The present work suggests that the α,β-unsaturated lactone moiety in mycoepoxydienes might be responsible for the cytotoxicity.

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Dr. Prasat Kittakoop

Chulabhorn Research Institute

Vipavadee-Rangsit Highway

Bangkok 10210

Thailand

Phone: +66-86-975-5777

Fax: +662-574-0622 ext. 1513

Email: prasatkittakoop@yahoo.com