Planta Med 2006; 72(1): 87-89
DOI: 10.1055/s-2005-873185
Letter
© Georg Thieme Verlag KG Stuttgart · New York

New Cytotoxic Guttiferone Analogues from Garcinia virgata from New Caledonia

Joumaa Merza1 , Sabine Mallet1 , Marc Litaudon2 , Vincent Dumontet3 , Denis Séraphin1 , Pascal Richomme1
  • 1SONAS, UFR des Sciences Pharmaceutiques et d’Ingénierie de la Santé, Angers, France
  • 2Laboratoire des Plantes Médicinales du CNRS, Nouméa, New Caledonia
  • 3Institut de Chimie des Substances Naturelles, CNRS, Gif-sur-Yvette, France
Further Information

Publication History

Received: April 14, 2005

Accepted: June 3, 2005

Publication Date:
10 November 2005 (online)

Abstract

There are thirteen endemic species belonging to the genus Garcinia in New Caledonia. Among them, G. virgata is an evergreen tree mainly growing in the rain forests of this island. Fractionation of the cyclohexane extract of the stem bark of this plant produced the known benzophenones guttiferone E and xanthochymol, together with two new guttiferone analogues, namely guttiferones I (1) and J (2). The structures of these benzophenones were mainly elucidated using 1D and 2D NMR spectroscopy. Compounds 1 and 2 were weakly cytotoxic on the KB cell line with IC50 values of 4.70 and 5.0 μg/mL respectively.

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Prof. Pascal Richomme

SONAS

UFR des Sciences Pharmaceutiques et Ingénierie de la Santé

16 Bd Daviers

49100 Angers

France

Phone: +33-2-41-22-66-58

Fax: +33-2-41-48-67-33

Email: pascal.richomme@univ-angers.fr