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DOI: 10.1055/s-2007-985882
© Georg Thieme Verlag KG Stuttgart · New York
Delirium Associated with Paroxetine in an Elderly Depressive Patient: A Case Report
Publikationsverlauf
received 12.03.2007
revised 12.06.2007
accepted 03.07.2007
Publikationsdatum:
17. September 2007 (online)
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Introduction
Paroxetine is one of the selective serotonin reuptake inhibitors (SSRIs) commonly used as a first-choice agent in depression treatment. These agents should be selected carefully based on complications and the age-related reduction of drug metabolism in elderly patients to reduce the risk of side effects.
Delirium indicates acute reversible changes in the consciousness level, being common in elderly persons [7]. Etiological factors for delirium include encephalopathy, systemic disorders, alcohol, and drugs. Delirium also seems to be frequently caused by the intake of anticholinergic, antidepressive, and dopamine-activating drugs [6]. In this study, we report on an elderly patient with depression in whom paroxetine therapy at an increased dose induced delirium.
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Correspondence
M. WakenoMD
Department of Neuropsychiatry
Kansai Medical University
10-15 Fumizonocho
Moriguchi
570-8506 Osaka
Japan
Telefon: +81/6/6992 10 01
Fax: +81/6/6995 26 69
eMail: wakenoma@takii.kmu.ac.jp