Exp Clin Endocrinol Diabetes 2008; 116(1): 65-68
DOI: 10.1055/s-2007-985148
Short Communication

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Circulating FGF-21 Levels in Normal Subjects and in Newly Diagnose Patients with Type 2 Diabetes Mellitus

W.-W. Chen 1 , L. Li 2 , G.-Y. Yang 1 , K. Li 1 , X.-Y. Qi 1 , W. Zhu 1 , Y. Tang 3 , H. Liu 4 , G. Boden 5
  • 1Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China
  • 2Department of Clinical Biochemistry and the Key Laboratory of Laboratory Medical Diagnostics in the Ministry of Education, Chongqing Medical University, Chongqing China
  • 3Oncology Research, Centocor, Inc., Malvern, Pennsylvania, USA
  • 4Department of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi, USA
  • 5The Division of Endocrinology/Diabetes/Metabolism and the Clinical Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
Further Information

Publication History

received 02.06.2007 first decision 12.06.2007

accepted 04.07.2007

Publication Date:
09 October 2007 (online)

Abstract

Fibroplast growth factor (FGF-21) is a recently discovered metabolic regulator. Its pathophysiologic role in humans remains unknown. In this study, we have investigated whether or not plasma FGF-21 level was different in patients with type 2 diabetes mellitus (T2DM) and non-diabetic controls. We also assessed associations between plasma FGF-21 body composition and several metabolic parameters. Fasting FGF-21 levels were significantly increased in patients with T2DM compared with controls (1.82±0.65 vs. 1.53±0.60 μg/L, P<0.05). In T2DM patients, fasting plasma FGF-21 correlate negatively with fasting blood glucose (r=-0.31, P<0.05). Multiple regression analysis showed that FBG, plasma insulin and HOMAIS were independent influencing plasma FGF-21 levels. The present work suggests a potential role for FGF-21 in the pathogenesis of insulin resistance and T2DM.

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Correspondence

Dr. G.-Y. YangPhD 

Department of Endocrinology

The Second Affiliated Hospital

Chongqing Medical University

400010 Chongqing

China

Phone: +86/23/68 48 61 15

Fax: +86/23/68 48 61 15

Email: gangyiyang@yahoo.com.cn