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Horm Metab Res 1997; 29(9): 417-421
DOI: 10.1055/s-2007-979068
DOI: 10.1055/s-2007-979068
Originals Basic
© Georg Thieme Verlag Stuttgart · New York
GLP-1 (7 - 36) Amide: Effects on Glucose Transport and Metabolism in Rat Adipose Tissue
Further Information
Publication History
1996
1997
Publication Date:
23 April 2007 (online)
In rat adipocytes, GLP-1 (7-36) amide induced an increment in 2-deoxy-glucose uptake, which was additive to that of insulin. Furthermore, in rat fat, GLP-1 (7-36) amide provoked a rise in glycogen synthesis, glucose oxidation and utilization and lipogenesis, the increments being lower than those obtained with insulin. These data support the idea that GLP-1 exerts insulin-like effects on glucose metabolism in rat adipose tissue, as it does in rat hepatocytes and skeletal muscle, although with a lower potency than that of insulin.
Key words
GLP-1 - Adipose Tissue - Glucose Metabolism - Glucose Transport