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Horm Metab Res 1993; 25(11): 593-595
DOI: 10.1055/s-2007-1002184
Originals Clinical

© Georg Thieme Verlag, Stuttgart · New York

Comparison of Plasma Pancreastatin and GAWK Concentrations, Presumed Processing Products of Chromogranin A and B, in Plasma of Patients with Pancreatic Islet Cell Tumors

D. Yasuda1 , H. Iguchi2 , A. Funakoshi1 , H. Wakasugi1 , K. Sekiya3 , T. Misawa3 , K. Tateishi4 , S. R. Bloom5 , H. Nawata3
  • 1Department of Gastroenterology, National Kyushu Cancer Center, Fukuoka
  • 2Department of Biochemistry, National Kyushu Cancer Center, Fukuoka
  • 3Third Department of Internal Medicine, Faculty of Medicine, Kyusyu University, Fukuoka
  • 4First Department of Biochemistry, Fukuoka University School of Medicine, Fukuoka, Japan
  • 5Department of Medicine, Hammersmith Hospital, London, England
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Publication History

1993

1993

Publication Date:
14 March 2008 (online)

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Summary

Plasma pancreastatin (PST) and GAWK, peptides processed from chromogranin A and B, were elevated in patients with various neuroendocrine tumors. In the present study, we measured plasma PST- and GAWK-like immunoreactivity (LI) concentrations in 12 patients with pancreatic islet cell tumors and evaluated them as a marker for these tumors. We also performed the gel filtration of the plasma from a gastrinoma patient and investigated the processing of PST and GAWK in plasma. Elevation of plasma PST-LI was found in 4 of 12 patients (33%) and elevation of plasma GAWK-LI was found in 6 of 12 patients (50%). A significant correlation was not found between plasma PST- and GAWK-LI concentrations of the patients. In the gel permeation chromatography of the plasma from a gastrinoma patient, PST-LI composed of a single peak but GAWK-LI composed of several components with wide range molecular weights.

Key words

Pancreastatin - GAWK - Islet Cell Tumors