Exp Clin Endocrinol Diabetes 2006; 114(10): 544-548
DOI: 10.1055/s-2006-948309
Article

© J. A. Barth Verlag in Georg Thieme Verlag KG · Stuttgart · New York

Changes and Relations of Circulating Visfatin, Apelin, and Resistin Levels in Normal, Impaired Glucose Tolerance, and Type 2 Diabetic Subjects

L. Li 1 , G. Yang 2 , Q. Li 1 , Y. Tang 3 , M. Yang 2 , H. Yang 2 , K. Li 2
  • 1Department of Clinical Biochemistry and the Key Laboratory of Laboratory Medical Diagnostics in the Ministry of Education, Chongqing University of Medical Sciences, Chongqing, China
  • 2Department of Endocrinology, The Second Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing, China
  • 3Oncology Research, Centocor, Inc., Malvern, Pennsylvania, USA
Further Information

Publication History

Received: April 4, 2006 First decision: May 19, 2006

Accepted: June 20, 2006

Publication Date:
19 December 2006 (online)

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Abstract

Visfatin and apelin are two novel adipocyte- secreted hormone proposed to link obesity with insulin resistance. In this study we investigated whether plasma visfatin and apelin levels were altered in normal, impaired glucose tolerance, and type 2 diabetic subjects. We also assessed the association between plasma visfatin, or apelin and body composition, metabolic parameters, and resistin concentrations in these subjects. The visfatin levels of fasting and 2-h post-glucose load were found to be significantly decreased in diabetics compared with the controls (P<0.05). In contrast, basal apelin levels were significantly increased in the IGT and diabetic subjects compared with the controls (P<0.05 and P<0.01). The apelin levels of 2-h post-glucose load were significantly higher than the basal levels in every group (all P<0.05). Fasting plasma visfatin was found to correlate positively and significantly with BMI, WHR, and fasting plasma resistin, but negatively with HbA1c and 2 h OGTT glucose. Multiple regression analysis showed that WHR, HbA1c, 2 h OGTT glucose were independent related factors influencing plasma visfatin levels. Fasting plasma apelin levels correlated positively with HOMA-IR, BMI, TC, LDL-C, FBG and Fasting plasma insulin. Multiple regression analysis also showed that HOMA-IR, BMI, and TC were independent related factors influencing plasma apelin levels. The present work indicates the potential link of visfatin and apelin with the pathogenesis of insulin resistance and T2DM.