Pharmacopsychiatry 2005; 38(4): 184-186
DOI: 10.1055/s-2005-871244
Letter
Letter to the Editor
© Georg Thieme Verlag Stuttgart · New York

A Neuroendocrinological Hypothesis on Gender Effects of Naltrexone in Relapse Prevention Treatment

Letter to the EditorF. Kiefer1 , 2 , H. Jahn2 , K. Wiedemann2
  • 1Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health (CIMH) Mannheim, University of Heidelberg, Germany
  • 2Department of Psychiatry, University Hospital of Hamburg, Germany
Further Information

Publication History

Received: 20.7.2004 Revised: 5.10.2004

Accepted: 29.11.2004

Publication Date:
18 July 2005 (online)

The ability of naltrexone to increase hypothalamo-pituitary-adrenocortical (HPA)-axis activity was recently reported to be associated with its effects on the reduction of craving for alcohol. We now present data showing naltrexone to be more efficacious in female alcoholics. Since HPA-axis activity displays gender effects, the interaction of naltrexone with HPA-axis might be interpreted as a key mechanism of action that could explain the observed gender differences in the abstinence maintenance treatment of alcohol addiction.

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Prof. Dr. Falk Kiefer

Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health (CIMH) Mannheim

University of Heidelberg

Germany

Phone: +49 621 1703 3522

Fax: +49 621 1703 3505

Email: kiefer@zi-mannheim.de