Planta Med 2004; 70(6): 556-560
DOI: 10.1055/s-2004-827157
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag KG Stuttgart · New York

Steroidal Saponins from Myriopteron extensum and Their Cytotoxic Activity

Ming-Fu Yang1 , 2 , Yu-Yuan Li1 , Xiao-Ping Gao3 , Bo-Gang Li1 , 3 , Guo-Lin Zhang1
  • 1Chengdu Institute of Biology, the Chinese Academy of Sciences, Chengdu, P. R. China
  • 2Chengdu Institute of Organic Chemistry, the Chinese Academy of Sciences, Chengdu, P. R. China
  • 3Pharmaceutical Institute of Di-Ao Pharmaceutical Group, Chengdu, P. R. China
Further Information

Publication History

Received: November 13, 2003

Accepted: March 7, 2004

Publication Date:
01 July 2004 (online)

Abstract

Two new steroidal saponins, extensumsides A (1) and B (2), were isolated from the whole plants of Myriopteron extensum (Wight) K. Schum. Their structures were elucidated as 17β-uzarigenin-3-O-β-glucopyranosyl-(1→6)-β-glucopyranosyl-(1→4)-β-thevetopyranosyl-(1→4)-β-cymaropyranoside (1) and 12-(3-methylbut-2-enoyloxy)pregn-5-en-20-one 3-O-[β-cymaropyranosyl-(1→4)-β-cymaropyranosyl-(1→4)-β-thevetopyranosyl-(1→4)-(6-O-sulfo-β-glucopyranoside)] (2) on the basis of chemical and spectral evidence. Extensumside A exhibited significant cytotoxicity against eight cancer cell lines with a mean GI50 value of 0.346 μg/mL.

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Prof. Dr. Guo-Lin Zhang

Chengdu Institute of Biology

The Chinese Academy of Sciences

P. O. Box 416

Chengdu 610041

P. R. China

Phone: +86-28-8522-5401

Fax: +86-28-8522-5401

Email: zhanggl@cib.ac.cn