Planta Med 2004; 70(1): 79-80
DOI: 10.1055/s-2004-815463
Letter
© Georg Thieme Verlag Stuttgart · New York

Neuroprotective Lignans from the Bark of Machilus thunbergii

Choong Je Ma1 , Sang Hyun Sung2 , Young Choong Kim1
  • 1College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul, Korea
  • 2Institute for Life Science, Elcom Science Co., Ltd., Seoul, Korea
This project was supported by NCCAM Grant No. 1 RO1-AT00106 - 05.
Further Information

Publication History

Received: June 23, 2003

Accepted: November 9, 2003

Publication Date:
06 February 2004 (online)

Abstract

The CH2Cl2 fraction of the bark of Machilus thunbergii Sieb. et Zucc. (Lauraceae) significantly protected primary cultures of rat cortical cells exposed to the excitotoxic amino acid, L-glutamate. (-)-Isoguaiacin, meso-dihydroguaiaretic acid, machilin A, (+)-galbelgin, licarin A, (-)-sesamin, and (+)-guaiacin were isolated by bioactivity-guided fractionation from the CH2Cl2 fraction and further separated using chromatographic techniques. Isoguaiacin, meso-dihydroguaiaretic acid, licarin A and (+)-guaiacin had significant neuroprotective activities against glutamate-induced neurotoxicity in primary cultures of rat cortical cells at concentrations ranging from 0.1 μM to 10.0 μM.

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Young Choong Kim

College of Pharmacy

Seoul National University

San 56-1

Shillim-Dong

Kwanak-Gu

Seoul, 151-742

Korea

Phone: +82-2-880-7842

Fax: +82-2-888-2933

Email: youngkim@plaza.snu.ac.kr