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DOI: 10.1055/s-2004-815463
Neuroprotective Lignans from the Bark of Machilus thunbergii
This project was supported by NCCAM Grant No. 1 RO1-AT00106 - 05.Publication History
Received: June 23, 2003
Accepted: November 9, 2003
Publication Date:
06 February 2004 (online)
![](https://www.thieme-connect.de/media/plantamedica/200401/lookinside/thumbnails/10.1055-s-2004-815463-1.jpg)
Abstract
The CH2Cl2 fraction of the bark of Machilus thunbergii Sieb. et Zucc. (Lauraceae) significantly protected primary cultures of rat cortical cells exposed to the excitotoxic amino acid, L-glutamate. (-)-Isoguaiacin, meso-dihydroguaiaretic acid, machilin A, (+)-galbelgin, licarin A, (-)-sesamin, and (+)-guaiacin were isolated by bioactivity-guided fractionation from the CH2Cl2 fraction and further separated using chromatographic techniques. Isoguaiacin, meso-dihydroguaiaretic acid, licarin A and (+)-guaiacin had significant neuroprotective activities against glutamate-induced neurotoxicity in primary cultures of rat cortical cells at concentrations ranging from 0.1 μM to 10.0 μM.
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Young Choong Kim
College of Pharmacy
Seoul National University
San 56-1
Shillim-Dong
Kwanak-Gu
Seoul, 151-742
Korea
Phone: +82-2-880-7842
Fax: +82-2-888-2933
Email: youngkim@plaza.snu.ac.kr