Seminars in Neurosurgery 2002; 13(3): 265-278
DOI: 10.1055/s-2002-39820
Copyright © 2002 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Carotid Dissection: A Clinical Review

Jonathan E. Martin, Rocco A. Armonda
  • Walter Reed Army Medical Center, Washington, D.C., and National Naval Medical Center, Bethesda, Maryland
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Publikationsverlauf

Publikationsdatum:
24. Juni 2003 (online)

ABSTRACT

Carotid artery dissection (CD) is an unusual pathological entity capable of producing devastating neurological deficits in affected patients. Symptoms include one or more of the clinical triad of headaches, oculosympathetic dysfunction, and retinal or cerebral ischemia. Cerebral angiography remains the gold standard for the diagnosis of carotid dissection. However, magnetic resonance angiography (MRA) and computed tomographic angiography (CTA) are emerging as both sensitive and specific modalities for the diagnosis of carotid artery disease. Management of CD remains controversial; the efficacy of anticoagulation, the current standard of care for initial management of CD, has not been demonstrated in a clinical trial. The authors review management options to include anticoagulation, antiplatelet agents, endovascular stenting, and surgical management of carotid dissection.

REFERENCES

  • 1 Verneuil M. Contusions multiples, deire, violent, hemiplegie a droite, signes de compression cerebrale.  Bull Acad Natl Med (Paris). 1872;  1 46-56
  • 2 Jentzer A. Dissecting aneurysms of the left internal carotid artery.  Angiology . 1954;  5 232-234
  • 3 Bogousslavsky J, Pierre P. Ischemic stroke in patients under age 45.  Neurol Clin . 1992;  10 113-124
  • 4 Cogbill T H, Moore E E, Meissner M. et al . The spectrum of blunt injury to the carotid artery: a multicenter perspective.  J Trauma . 1994;  37 473-479
  • 5 Milhaud D, de Freitas R G, van Melle G, Bogousslavsky J. Occlusion due to carotid artery dissection: a more severe disease than previously suggested.  Arch Neurol . 2002;  59 557-561
  • 6 Schievink W I, Mokri B, Whisnant J P. Internal carotid artery dissection in a community: Rochester, Minnesota, 1987-1992.  Stroke . 1993;  24 1678-1680
  • 7 Mokri B. Spontaneous dissections of internal carotid arteries.  Neurologist . 1997;  3 104-119
  • 8 Davis J, Holbrook T, Hoyt D. Blunt carotid artery dissection: incidence, associated injuries, screening, and treatment.  J Trauma . 1990;  30 1514-1517
  • 9 Biffl W L, Moore E E, Ryu R K. et al . The unrecognized epidemic of blunt carotid arterial injuries: early diagnosis improves neurologic outcome.  Ann Surg . 1998;  228 462-470
  • 10 Bouthillier A, van Loveren R H, Keller J T. Segments of the internal carotid artery: a new classification.  Neurosurgery . 1996;  38 425-433
  • 11 Resnick D K, Subach B R, Marion D W. The significance of carotid canal involvement in basilar cranial fracture.  Neurosurgery . 1997;  40 1177-1181
  • 12 Mokri B, Sundt Jr M T, Houser O W, Piepgras D G. Spontaneous dissection of the cervical internal carotid artery.  Ann Neurol . 1986;  19 126-138
  • 13 Moarr J J. Traumatic rupture of the cervical carotid arteries: an autopsy and histopathological study of 200 cases.  Forensic Sci Int . 1987;  34 227-244
  • 14 Schievink W I, Michels V V, Piepgras D G. Neurovascular manifestations of heritable connective tissue disorders: a review.  Stroke . 1994;  25 889-903
  • 15 Brandt T, Hausser I, Orberk E. et al . Ultrastructural connective tissue abnormalities in patients with spontaneous cervicocerebral artery dissections.  Ann Neurol . 1998;  44 281-285
  • 16 Cardon C, Diemont F, Julia P, Chemla E, Fabiani J N. Bilateral carotid dissection and factor V mutation: a second case.  Ann Vasc Surg . 2000;  14 503-506
  • 17 Schievink W I, Wijdicks E FM, Kuiper J D. Seasonal pattern of spontaneous cervical artery dissection.  J Neurosurg . 1998;  89 101-103
  • 18 Grotta J C, Ward R E, Flynn T C, Cullen M L. Spontaneous internal carotid artery dissection associated with fibromuscular dysplasia.  J Cardiovasc Surg . 1982;  23 512-514
  • 19 Jeret J S. More complications of spinal manipulation.  Stroke . 2001;  32 1936-1937
  • 20 Woll M M, Goff Jr M J, Gillespie D L, Minken S L. Bilateral spontaneous dissection of the internal carotid arteries: a case report.  Vasc Surg . 2001;  35 221-224
  • 21 Evers S, Altenmuller E, Ringlestein E B. Cerebrovascular ischemic events in wind-instrument players.  Neurology . 2000;  55 865-867
  • 22 Cloft H J, Jensen M E, Kallmes D F, Dion J E. Arterial dissections complicating cerebral angiography and cerebrovascular interventions.  Am J Neuroradiol . 2000;  21 541-545
  • 23 Singhal A, Golomb M, Mochida G. et al . Another case of internal carotid artery dissection after mandibular osteotomy.  J Oral Maxillofac Surg . 1998;  56 115-116
  • 24 Biffl W L, Moore E E, Offner P J, Brega K E, Franciose R J, Burch J M. Blunt carotid arterial injuries: implications of a new grading scale.  J Trauma . 1999;  47 845-853
  • 25 Biousse V, D'Anglejan-Chatillon J, Massiou H, Bousser M G. Head pain in nontraumatic carotid artery dissection: a series of 65 patients.  Cephalgia . 1994;  14 33-36
  • 26 Silbert P L, Mokri B, Schievink W I. Headache and neck pain in spontaneous internal carotid and vertebral artery dissections.  Neurology . 1995;  45 1517-1522
  • 27 Mokri B, Sundt T M, Houser O W, Piepgras D G. Spontaneous dissection of the cervical internal carotid artery.  Ann Neurol . 1986;  19 126-138
  • 28 Harris J P, Horlbeck D M, Brew K H. Unique case of pulsatile tinnitus.  Ann Otol Rhinol Laryngol . 2000;  109 1103-1106
  • 29 Shahab R, Savy L E, Croft C B, Hung T. Isolated hypoglossal nerve palsy due to internal carotid artery dissection.  J Laryngol Otol . 2001;  115 587-589
  • 30 Opeskin K. Traumatic carotid artery dissection.  Am J Forensic Med Pathol . 1997;  18 251-257
  • 31 Resnick D K, Subach B R, Marion D W. The significance of carotid canal involvement in basilar cranial fracture.  Neurosurgery . 1997;  40 1177-1187
  • 32 Touze E, Randoux B, Meary E, Arquizan C, Meder J F, Mas J L. Aneurysmal forms of cervical artery dissection: associated factors and outcome.  Stroke . 2001;  32 418-423
  • 33 Cloft H J, Jensen M E, Kallmes D F, Dion J E. Arterial dissections complicating cerebral angiography and cerebrovascular interventions.  Am J Neuroradiol . 2000;  21 541-545
  • 34 Landwehr P, Schulte O, Voshage G. Ultrasound examination of carotid and vertebral arteries.  Eur Radiol . 2001;  11 1521-1534
  • 35 Eljamel M SM, Humphrey P RD, Shaw M DM. Dissection of the cervical internal carotid artery: the role of Doppler/Duplex studies and conservative management.  J Neurol Neurosurg Psych . 1990;  53 379-383
  • 36 Bowen B C, Quencer R M, Margosian P, Pattany P M. MR Angiography of occlusive disease of the arteries in the head and neck: current concepts.  Am J Roentgenol . 1994;  162 9-18
  • 37 Levy C, Laissy J P, Raveau V. et al . Carotid and vertebral artery dissections: three-dimensional time-of-flight MR angiography and MR imaging versus conventional angiography.  Radiology . 1994;  190 97-103
  • 38 Phan T, Huston J, Bernstein M A, Riederer S J, Brown R D. Contrast-enhanced magnetic resonance angiography of the cervical vessels: experience with 422 patients.  Stroke . 2001;  32 2282-2286
  • 39 Petro G R, Witwer G A, Cacayorin E D. et al . Spontaneous dissction of the cervical internal carotid artery: correlation of arteriography, CT, and pathology.  Am J Neuroradiol . 1986;  7 1053-1058
  • 40 LeClerc X, Godefroy O, Salhi A, Lucas C, Leys D, Pruvo J P. Helical CT for the diagnosis of extracranial internal carotid artery dissection.  Stroke . 1996;  27 461-466
  • 41 Dal Pozzo G, Mascalchi M, Fonda C, Cadelo M, Ronchi O, Inzitari D. Lower cranial nerve palsy due to dissection of the internal carotid artery: CT and MR imaging.  J Comput Assist Tomogr . 1989;  13 989-995
  • 42 Wintermark M, Reichhart M, Cuisenaire O. et al . Comparison of admission perfusion computed tomography and qualitative diffusion- and perfusion-weighted magnetic resonance imaging in acute stroke patients.  Stroke . 2002;  33 2025-2031
  • 43 LeClerc X, Godefroy O, Salhi A, Lucas C, Leys D, Pruvo J P. Helical CT for the diagnosis of extracranial internal carotid artery dissection.  Stroke . 1996;  27 461-466
  • 44 Egelhof T, Jansen O, Winter R, Sartor K. CT angiography in dissections of the internal carotid artery: value of a new examination technique in comparison with DSA and Doppler ultrasound [in German].  Radiologe . 1996;  36 850-854
  • 45 Biffl W L, Moore E E, Ryu R K. et al . The unrecognized epidemic of blunt carotid arterial injuries: early diagnosis improves neurologic outcome.  Ann Surg . 1998;  228 462-470
  • 46 Biffl W L, Moore E E, Offner P J, Brega K E, Franciose R J, Burch J M. Blunt carotid arterial injuries: implications of a new grading scale.  J Trauma . 1999;  47 845-852
  • 47 Lucas C, Moulin T, Deplanque D, Tatu L, Chavot D. Stroke patterns of internal carotid artery dissections in 40 patients.  Stroke . 1998;  29 2646-2648
  • 48 Molina C A, Alvarez-Sabin J, Schonewille W. et al . Cerebral microembolism in acute spontaneous internal carotid artery dissection.  Neurology . 2000;  55 1738-1740
  • 49 Stroke Prevention in Atrial Fibrillation Collaborators. Stroke prevention in atrial fibrillation study.  Final results. Circulation . 1991;  84 527-539
  • 50 Algra A, de Schryver L E, van Gijn J, Kappelle L J, Koudstaal P J. Oral anticoagulants versus antiplatelet therapy for preventing further vascular events after transient ischaemic attack or minor stroke of presumed arterial origin.  Cochrane Database Syst Rev . 2001;  4 CD001342
  • 51 International Stroke Trial Collaborative Group. The international stroke trial (IST): a randomized trial of aspirin, subcutaneous heparin, both, or neither among 19,435 patients with acute ischaemic stroke.  Lancet . 1997;  349 1569-1581
  • 52 Richardson J D, Simpson C, Miller F B. Management of carotid artery injury.  Surgery . 1988;  104 673-680
  • 53 Fisher C M, Ojemann R G, Roberson G H. Spontaneous dissection of cervico-cerebral arteries.  Can J Neurol Sci . 1978;  5 9-19
  • 54 Lyrer P, Engelter S. Antithrombotic drugs for carotid artery dissection.  Cochrane Database Syst Rev . 2000;  4 CD000255
  • 55 Fabian T C, Patton J H, Croce M A, Minard G, Kudsk K A, Pritchard F E. Blunt carotid injury: importance of early diagnosis and anticoagulant therapy.  Ann Surg . 1996;  223 513-525
  • 56 Milhaud D, de Freitas R G, van Melle G, Bogousslavsky J. Occlusion due to carotid artery dissection: a more severe disease than previously suggested.  Arch Neurol . 2002;  59 557-561
  • 57 Biffl W L, Moore E E, Ryu R K. et al . The unrecognized epidemic of blunt carotid arterial injuries: early diagnosis improves neurologic outcome.  Ann Surg . 1998;  228 462-470
  • 58 Sturzenegger M, Mattle H P, Rivoir A, Baumgartner R W. Ultrasound findings in carotid artery dissection: analysis of 43 patients.  Neurology . 1995;  45 691-698
  • 59 Yamaura A, Ono J, Hirai S. Clinical picture of intracranial nontraumatic dissecting aneurysms.  Neuropathology . 2000;  20 85-90
  • 60 Coull B M, Williams L S, Goldstein L B. et al . Anticoagulants and antiplatelet agents in acute ischemic stroke: report of the joint stroke Guideline Committee of the American Academy of Neurology and the American Stroke Association.  Neurology . 2002;  59 13-23
  • 61 Fabian T C, Patton J H, Croce M A, Minard G, Kudsk K A, Pritchard F E. Blunt carotid injury: importance of early diagnosis and anticoagulant therapy.  Ann Surg . 1996;  223 513-525
  • 62 Mokri B, Sundt T M, Houser O W, Piepgras D G. Spontaneous dissection of the cervical internal carotid artery.  Ann Neurol . 1986;  19 126-138
  • 63 Kraus R R, Bergstein J M, DeBord J R. Diagnosis, treatment, and outcome of blunt carotid arterial injuries.  Am J Surg . 1999;  178 190-193
  • 64 Parikh A A, Luchette F A, Valente J F. Blunt carotid injuries.  J Am Coll Surg . 1997;  185 80-86
  • 65 International Stroke Trial Collaborative Group. The international stroke trial: a randomized trial of aspirin, subcutaneous heparin, both, or neither among 19,435 patients with acute ischaemic stroke.  Lancet . 1997;  349 1569-1581
  • 66 Wahl W L, Brandt M, Thompson G, Taheri P A, Greenfield L J. Antiplatelet therapy: an alternative to heparin for blunt carotid injury.  J Trauma . 2002;  52 896-901
  • 67 Marks M P, Dake M D, Steinber G K, Norbash A M, Lane B. Stent placement for arterial and venous cerebrovascular disease: preliminary experience.  Radiology . 1994;  191 441-446
  • 68 Liu A Y, Paulsen R D, Marcellus M L, Steinberg G K, Marks M P. Long-term outcomes after carotid stent placement treatment of carotid artery dissection.  Neurosurgery . 1999;  45 1368-1373
  • 69 Bejjani G K, Monsein L H, Laird J R, Satler L F, Starnes B W, Aulisi E F. Treatment of symptomatic cervical carotid dissections with endovascualr stents.  Neurosurgery . 1999;  755-760
  • 70 Muller B T, Luther B, Hort W, Neumann-Haefelin T, Aulich A, Sandmann W. Surgical treatment of 50 carotid dissections: indications and results.  J Vasc Surg . 2000;  31 980-988
  • 71 Fry R E, Wry W J. Extracranial carotid artery injuries.  Surgery . 1980;  88 581-587
  • 72 The IC/IC Bypass Study Group. Failure of extracranial-intracranial arterial bypass to reduce the risk of ischmic stroke: results of an international randomized trial.  N Engl J Med . 1985;  313 1191-1200
  • 73 Adams H P, Powers W J, Grubb R L, Clarke W R, Woolson R F. Preview of a new trial of extracranial-to-intracranial arterial anastomosis: the carotid occlusion surgery study.  Neurosurg Clin N America . 2001;  36 613-624
  • 74 Ueno M, Nishizawa S, Toyoda H. et al . Assessment of cerebal hemodynamics before and after revascularization in patients with occlusive cerebrovascular disease by means of quantitative IMP-SPECT with double injection protocol.  Ann Nucl Med . 2001;  15 209-215