New Regioselective Synthesis of 7H-Imidazo[2,1-b][1,3]thiazine and 2H,6H-Pyrimido[2,1-b][1,3]thiazine Derivatives.

Cyrille Landreau; David Deniaud; Alain Reliquet; Jean Claude Meslin

doi:10.1055/s-2002-20044

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Synthesis 2002(3): 0403-0408
DOI: 10.1055/s-2002-20044

PAPER

New Regioselective Synthesis of 7H-Imidazo[2,1-b][1,3]thiazine and 2H,6H-Pyrimido[2,1-b][1,3]thiazine Derivatives.

Cyrille Landreau, David Deniaud*, Alain Reliquet, Jean Claude Meslin
Laboratoire de Synthèse Organique, UMR CNRS 6513, Faculté des Sciences et des Techniques 2, Rue de la Houssinière, BP 92208, 44322 Nantes Cedex 03, France
Fax: +33(2)51125402; e-Mail: david.deniaud@chimie.univ-nantes.fr;

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Publikationsverlauf

Received 2 January 2002
Publikationsdatum:
28. Juli 2004 (online)

Abstract
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Abstract

A series of the title compounds were prepared by the reaction of amidines 2 with α-bromoketones, acid chlorides or acrylic dienophiles. The four steps synthesis reaction from thiourea and full characterisation of 7H-imidazo[2,1-b][1,3]thiazines 4, 2H,6H-pyrimido[2,1-b][1,3]thiazin-6-ones 5, and 2H,6H-pyrimido[2,1-b][1,3]thiazines 6 are described.

Key words

bicyclic compounds - heterocycles - alkylations - acylations - Diels-Alder reactions

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