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Synthesis 2001(13): 2015-2020
DOI: 10.1055/s-2001-17718
PAPER
© Georg Thieme Verlag Stuttgart · New York

A Facile Access to Imidazo[2,1-b]thiazole and Thiazolo[3,2-a]pyrimidine Derivatives

Cyrille Landreau, David Deniaud*, Alain Reliquet, Jean Claude Meslin
Laboratoire de Synthèse Organique, UMR CNRS 6513, Faculté des Sciences et des Techniques, 2, Rue de la Houssinière, BP 92208, 44322 Nantes Cedex 03, France
Fax: +33(2)51125402; e-Mail: david.deniaud@chimie.univ-nantes.fr;
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Publication History

Received 1 June 2001
Publication Date:
10 August 2004 (online)

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Abstract

A new and efficient method for the synthesis of 2,3-dihydroimidazo[2,1-b]thiazoles 3, 2,3-dihydro-5H-thiazolo[3,2-a]pyrimidin-5-ones 4 and 2,3-dihydro-5H-thiazolo[3,2-a]pyrimidines 5 has been developed. The reactions of N′-(4,5-dihydrothiazol-2-yl)-N,N-dimethylamidines 1 with α-halogenoketones, acid chlorides or acrylic dienophiles were performed, leading to the title products.

Keywords

bicyclic compounds - heterocycles - acylations - alkylations - Diels-Alder reactions

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