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Sleep Breath 2001; 05(1): 047-052
DOI: 10.1055/s-2001-12793
EMERGING RESEARCH

Copyright © 2001 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Incorporating Inheritance into Models for Understanding Ventilatory Behavior

Kingman P. Strohl, Shyam Subramanian, Fang Han, Karem Principe, Theodore E. Dick
  • Department of Medicine, Louis Stokes VA Medical Center, and Case Western Reserve University, Cleveland, Ohio
Further Information

Publication History

Publication Date:
31 December 2001 (online)

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ABSTRACT

Ventilation and its components (frequency and tidal volume) appear to be determined to a significant extent by inheritance. Gene manipulation, gene identification, and functional genomics now offer powerful tools to identify the strength and mode of inheritance for ventilatory behavior under steady-state and non-steady-state conditions, in health and in disease. Conscious integration of genetic principles into existing explanatory models may increase the likelihood of detecting traits that correlate with protein systems responsible for the structures and the functional components of respiration.

KEYWORD

Modeling - quantitative genetics - respiration

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