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Synlett 1998; 1998(8): 918-920
DOI: 10.1055/s-1998-1811
DOI: 10.1055/s-1998-1811
letter
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Superacid Activated Condensation of Parabanic Acid and Derivatives with Arenes. A New Synthesis of Phenytoin and 5,5-Diarylhydantoins
Further Information
Publication History
Publication Date:
31 December 2000 (online)
![](https://www.thieme-connect.de/media/synlett/199808/lookinside/thumbnails/10.1055-s-1998-1811-1.jpg)
A new synthetic route in phenytoin and 5,5-diarylhydantoins is reported. Parabanic acid is converted to the 5,5-diarylhydantoins (65-98% yield) from CF3SO3H and arenes. Deuterium substituted produts are prepared in high yield from parabanic acid, CF3SO3D, and deuterated arenes.
phenytoin - hydantoin - heterocycle - superacid - electrophile