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Eur J Pediatr Surg 2020; 30(04): 317-325
DOI: 10.1055/s-0039-1692655
Review Article
Georg Thieme Verlag KG Stuttgart · New York

Interventional Radiology-Guided Procedures in the Treatment of Pediatric Solid Tumors: A Systematic Review and Meta-Analysis

Elisa Zambaiti  ∗
1   Department of Women's and Children's Health, Pediatric Surgery, Universita degli Studi di Padova Dipartimento di Medicina, Padova, Italy
,
Alexander Siles Hinojosa  ∗
2   Pediatric Surgery Department, Miguel Servet University Hospital, Zaragoza, Spain
,
Valentina Montano∗
3   Depatment Pediatric Surgery, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
,
Annika Mutanen∗
4   Division of General and Thoracic Surgery, Hospital for Sick Children, Toronto, Ontario, Canada
,
Mathilde Glenisson∗
5   Department of Pediatric Surgery and Urology, Robert Debré Hospital, Assistance Publique-Hôpitaux de Pari (AP-HP), Paris, France
,
Sabine Sarnacki∗
6   Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Department of Pediatric Surgery and Urology, Descartes University, Université de Paris, Paris, France
,
Stephanie Franchi Abella∗
7   Pediatric Radiology Department, Assistance Publique-Hôpitaux de Pari (AP-HP), Bicêtre Hospital, Le Kremlin-Bicêtre, France
,
Daniele Pariente∗
7   Pediatric Radiology Department, Assistance Publique-Hôpitaux de Pari (AP-HP), Bicêtre Hospital, Le Kremlin-Bicêtre, France
,
Luca Pio
6   Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Department of Pediatric Surgery and Urology, Descartes University, Université de Paris, Paris, France
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Weitere Informationen

Publikationsverlauf

10. Januar 2019

14. Mai 2019

Publikationsdatum:
23. Juni 2019 (online)

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Abstract

Introduction The use of interventional radiology (IR) in the treatment of pediatric solid tumors has markedly increased over the last three decades. However, data on effectiveness of IR-techniques, such as embolization/ablation, are scarce. In this systematic review and meta-analysis, we examined the outcomes of IR-procedures in the treatment of solid tumors in children.

Materials and Methods Using a defined search strategy, we searched for studies reporting the use of IR-techniques for pediatric solid tumors from 1980 to 2017. Reports with less than three patients, review, and opinion articles were excluded. The study was conducted under preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. We analyzed dichotomous and continuous variables by appropriate statistical methods.

Results Of 567 articles screened, 21 papers met the inclusion criteria (12 retrospective, 7 prospective, and 2 randomized-control trials). Many of the analyzed papers described relatively small cohorts of patients. IR-guided procedures were mainly rescue procedures to treat primarily unresectable tumors, local recurrences, or metastases. Inclusion/exclusion criteria and success definition were not specified in most reports. Major side effects were documented in 17/286 (6%) infants, while minor side effects were self-limiting in most patients. Six studies had a comparison between tumor embolization (127 infants) to surgery or chemotherapy without IR-procedures (113 controls). The meta-analysis showed lower mortality (16 vs. 47%) and surgical time for resection (206 vs. 250 m), higher 2-year tumor-free survival (82 vs. 36%), and favorable histology in IR group (p < 0.001 for all).

Conclusion IR-guided techniques are promising in the treatment of pediatric solid tumors. Further prospective (randomized) trials are needed to clarify efficacy.

Keywords

interventional radiology - pediatric surgical oncology - radiologic embolization - pediatric oncology
 

  • References

  • 1 Vogl TJ, Nour-Eldin NA, Hammerstingl RM, Panahi B, Naguib NNN. Microwave ablation (MWA): Basics, technique and results in primary and metastatic liver neoplasms - review article. RoFo Fortschr Geb Rontgenstr Nuklearmed 2017; 189 (11) 1055-1066
    Thieme ConnectPubMedSuche in Google Scholar
  • 2 Kenny LM, Orsi F, Adam A. Interventional radiology in breast cancer. Breast 2017; 35: 98-103
    CrossrefPubMedSuche in Google Scholar
  • 3 Gummadi S, Eisenbrey JR, Lyshchik A. Contrast-enhanced ultrasonography in interventional oncology. Abdom Radiol (NY) 2018; 43 (11) 3166-3175
    CrossrefPubMedSuche in Google Scholar
  • 4 Rosenthal DI, Hornicek FJ, Wolfe MW, Jennings LC, Gebhardt MC, Mankin HJ. Percutaneous radiofrequency coagulation of osteoid osteoma compared with operative treatment. J Bone Joint Surg Am 1998; 80 (06) 815-821
    CrossrefPubMedSuche in Google Scholar
  • 5 Thomas PE, Macicek SL. Catheter ablation to treat supraventricular arrhythmia in children and adults with congenital heart disease: what we know and where we are going. Ochsner J 2016; 16 (03) 290-296
    PubMedSuche in Google Scholar
  • 6 Gómez FM, Patel PA, Stuart S, Roebuck DJ. Systematic review of ablation techniques for the treatment of malignant or aggressive benign lesions in children. Pediatr Radiol 2014; 44 (10) 1281-1289
    CrossrefPubMedSuche in Google Scholar
  • 7 Meyerson BA, Linderoth B. Mechanisms of spinal cord stimulation in neuropathic pain. Neurol Res 2000; 22 (03) 285-292
    CrossrefPubMedSuche in Google Scholar
  • 8 Formanek A, Probst P, Tadavarthy S, Castaneda-Zuniga WR, Amplatz K. (Transcatheter embolization [interventive radiology] in the pediatric age group and adolescent). Ann Radiol (Paris) 1979; 22 (2-3): 150-158
    PubMedSuche in Google Scholar
  • 9 Yevich S, Gaspar N, Tselikas L. , et al. percutaneous computed tomography-guided thermal ablation of pulmonary osteosarcoma metastases in children. Ann Surg Oncol 2016; 23 (04) 1380-1386
    CrossrefPubMedSuche in Google Scholar
  • 10 Botsa E, Poulou LS, Koutsogiannis I. , et al. CT-guided radiofrequency tumor ablation in children. Pediatr Radiol 2014; 44 (11) 1421-1425
    CrossrefPubMedSuche in Google Scholar
  • 11 Zhang XF, Liu XM, Wei T. , et al. Clinical characteristics and outcome of hepatocellular carcinoma in children and adolescents. Pediatr Surg Int 2013; 29 (08) 763-770
    CrossrefPubMedSuche in Google Scholar
  • 12 Liu WG, Gu WZ, Zhou YB, Tang HF, Li MJ, Ma WX. The prognostic relevance of preoperative transcatheter arterial chemoembolization (TACE) and PCNA/VEGF expression in patients with Wilms' tumour. Eur J Clin Invest 2008; 38 (12) 931-938
    CrossrefPubMedSuche in Google Scholar
  • 13 Tan X, Zhang J, Wen Z. , et al. Preoperative transcatheter arterial chemoembolization of hepatoblastoma in infants. J Vasc Interv Radiol 2014; 25 (07) 1029-1035
    CrossrefPubMedSuche in Google Scholar
  • 14 Li JP, Chu JP, Oh P. , et al. Characterizing clinicopathological findings of transarterial chemoembolization for Wilms tumor. J Urol 2010; 183 (03) 1138-1144
    CrossrefPubMedSuche in Google Scholar
  • 15 Tepper M, Vidone RA, Hayes MA, Lindenmuth WW, Kligerman MM. Preoperative irradiation in rectal cancer: initial comparison of clinical tolerance, surgical and pathologic findings. Am J Roentgenol Radium Ther Nucl Med 1968; 102 (03) 587-595
    CrossrefPubMedSuche in Google Scholar
  • 16 European Association for Study of Liver; European Organisation for Research and Treatment of Cancer. EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. Eur J Cancer 2012; 48 (05) 599-641
    CrossrefPubMedSuche in Google Scholar
  • 17 Liu B, Zhou L, Huang G. , et al. First experience of ultrasound-guided percutaneous ablation for recurrent hepatoblastoma after liver resection in children. Sci Rep 2015; 5: 16805
    CrossrefPubMedSuche in Google Scholar
  • 18 Bittles MA, Hoffer FA. Interventional radiology and the care of the pediatric oncology patient. Surg Oncol 2007; 16 (03) 229-233
    CrossrefPubMedSuche in Google Scholar
  • 19 Goldberg SN, Grassi CJ, Cardella JF. , et al; Society of Interventional Radiology Technology Assessment Committee and the International Working Group on Image-guided Tumor Ablation. Image-guided tumor ablation: standardization of terminology and reporting criteria. J Vasc Interv Radiol 2009; 20 (7, Suppl): S377-S390
    CrossrefPubMedSuche in Google Scholar
  • 20 Hoffer FA, Campos A, Xiong X, Wu S, Oigbokie N, Proctor K. Core body temperature regulation of pediatric patients during radiofrequency ablation. Pediatr Radiol 2007; 37 (03) 297-300
    CrossrefPubMedSuche in Google Scholar
  • 21 Brown SD, vanSonnenberg E. Issues in imaging-guided tumor ablation in children versus adults. AJR Am J Roentgenol 2007; 189 (03) 626-632
    CrossrefPubMedSuche in Google Scholar
  • 22 Rhim H, Choi J, Kim Y. , et al. Radiofrequency ablation of hepatic tumors: Post-ablation syndrome. J Vasc Interv Radiol 2000; 11 (Suppl.): 271-272
    PubMedSuche in Google Scholar
  • 23 Tovar-Spinoza Z, Choi H. Magnetic resonance-guided laser interstitial thermal therapy: report of a series of pediatric brain tumors. J Neurosurg Pediatr 2016; 17 (06) 723-733
    CrossrefPubMedSuche in Google Scholar
  • 24 Perilongo G, Shafford E, Maibach R. , et al; International Society of Paediatric Oncology-SIOPEL 2. Risk-adapted treatment for childhood hepatoblastoma. final report of the second study of the International Society of Paediatric Oncology--SIOPEL 2. Eur J Cancer 2004; 40 (03) 411-421
    CrossrefPubMedSuche in Google Scholar
  • 25 Zsíros J, Maibach R, Shafford E. , et al. Successful treatment of childhood high-risk hepatoblastoma with dose-intensive multiagent chemotherapy and surgery: final results of the SIOPEL-3HR study. J Clin Oncol 2010; 28 (15) 2584-2590
    CrossrefPubMedSuche in Google Scholar
  • 26 Arcement CM, Towbin RB, Meza MP. , et al. Intrahepatic chemoembolization in unresectable pediatric liver malignancies. Pediatr Radiol 2000; 30 (11) 779-785
    CrossrefPubMedSuche in Google Scholar
  • 27 Czauderna P, Zbrzezniak G, Narozanski W, Korzon M, Wyszomirska M, Stoba C. Preliminary experience with arterial chemoembolization for hepatoblastoma and hepatocellular carcinoma in children. Pediatr Blood Cancer 2006; 46 (07) 825-828
    CrossrefPubMedSuche in Google Scholar
  • 28 Li JP, Chu JP, Yang JY, Chen W, Wang Y, Huang YH. Preoperative transcatheter selective arterial chemoembolization in treatment of unresectable hepatoblastoma in infants and children. Cardiovasc Intervent Radiol 2008; 31 (06) 1117-1123
    CrossrefPubMedSuche in Google Scholar
  • 29 Oue T, Fukuzawa M, Kusafuka T, Kohmoto Y, Okada A, Imura K. Transcatheter arterial chemoembolization in the treatment of hepatoblastoma. J Pediatr Surg 1998; 33 (12) 1771-1775
    CrossrefPubMedSuche in Google Scholar
  • 30 Wang S, Yang C, Zhang J. , et al. First experience of high-intensity focused ultrasound combined with transcatheter arterial embolization as local control for hepatoblastoma. Hepatology 2014; 59 (01) 170-177
    CrossrefPubMedSuche in Google Scholar
  • 31 Zhang Y, Zhang WL, Huang DS. , et al. Clinical effectiveness of multimodality treatment on advanced pediatric hepatoblastoma. Eur Rev Med Pharmacol Sci 2014; 18 (07) 1018-1026
    PubMedSuche in Google Scholar
  • 32 Li MJ, Zhou YB, Huang Y. , et al. A retrospective study of the preoperative treatment of advanced Wilms tumor in children with chemotherapy versus transcatheter arterial chemoembolization alone or combined with short-term systemic chemotherapy. J Vasc Interv Radiol 2011; 22 (03) 279-286
    CrossrefPubMedSuche in Google Scholar
  • 33 Hoffer FA, Daw NC, Xiong X. , et al. A phase 1/pilot study of radiofrequency ablation for the treatment of recurrent pediatric solid tumors. Cancer 2009; 115 (06) 1328-1337
    CrossrefPubMedSuche in Google Scholar
  • 34 Krauel L, Albert A, Mora J. , et al. Use of angioembolization as an effective technique for the management of pediatric solid tumors. J Pediatr Surg 2009; 44 (09) 1848-1855
    CrossrefPubMedSuche in Google Scholar
  • 35 Gómez FM, Patel PA, Stuart S, Roebuck DJ. Systematic review of ablation techniques for the treatment of malignant or aggressive benign lesions in children. Pediatr Radiol 2014; 44 (10) 1281-1289
    CrossrefPubMedSuche in Google Scholar