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Thromb Haemost 1966; 16(01/02): 185-197
DOI: 10.1055/s-0038-1655636
Originalarbeiten — Original Articles — Travaux Originaux
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A Study of Coagulation Factor Levels in Women during Labour and in Their Newborn Infants

H. L Nossel   *
1   Departments of Medicine and Child Health, University of Cape Town and Groote Schuur Hospital, Observatory, Cape, South Africa
,
P Lanzkowsky   **
1   Departments of Medicine and Child Health, University of Cape Town and Groote Schuur Hospital, Observatory, Cape, South Africa
,
S Levy
1   Departments of Medicine and Child Health, University of Cape Town and Groote Schuur Hospital, Observatory, Cape, South Africa
,
R. S Mibashan
1   Departments of Medicine and Child Health, University of Cape Town and Groote Schuur Hospital, Observatory, Cape, South Africa
,
J. D. L Hansen
1   Departments of Medicine and Child Health, University of Cape Town and Groote Schuur Hospital, Observatory, Cape, South Africa
› Author Affiliations
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Publication Date:
26 June 2018 (online)

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Summary

1. Coagulation factors levels were measured in 10 normal mothers and in their infants within 15 min of birth and at 48-96 hrs of age.

2. In the mothers the levels of fibrinogen (532 mg/%), factors VIII (196%), IX (130%) and X (122%) were elevated; the levels of prothrombin (107%) and factor V (108%) were normal ; and the level of factor XI (69%) was reduced.

3. The infants blood examined within 15 min of birth had a slightly elevated factor VIII level (138%), slightly reduced fibrinogen (195 mg/%) and factor V levels (79%), low levels of prothrombin (55%) and factors IX (27%), X (35%) and XI (32%).

4. Blood from the infants at 48-96 hrs of age showed little change from the birth levels of factors V (89%), and VIII (116%) and a slight increase in factor XI level (39%). Four of the infants had received vitamin K1 and had higher levels of prothrombin and factors IX and X than the 7 who had not received vitamin K1.

5. These results are compared with those of previous studies and the possible mechanisms underlying the changes is discussed.

* Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, N. Y.


** Pediatric Hematology Division, Cornell University Medical Center, New York, N. Y. 1) Konakion (Roche).


 

  • References

  • 1 Aballi A, Lopez J. V, De Lamerens S, Rozengvaig S. Coagulation studies in the newborn period. Alterations of thromboplastin generation and effects of vitamin K in full-term and premature infants. Amer. J. Dis. Child 94: 589 1957;
    CrossrefPubMedSearch in Google Scholar
  • 2 Alexander B, Meyers L, Kenny J, Goldstein R, Gurewich V, Grinspoon L. Blood coagulation in pregnancy. Proconvertin and prothrombin and the hypercoagulable state. New Engl. J. Med 254: 358 1956;
    CrossrefPubMedSearch in Google Scholar
  • 3 Barkhan P. Christmas-factor activity of cord blood. Brit. J. Heamat 3: 215 1957;
    PubMedSearch in Google Scholar
  • 4 Beller F. K. Die Gerinnungsverhältnisse bei der Schwangeren und beim Neugeborenen. Barth; Leipzig: 1957
    Search in Google Scholar
  • 5 Beller F. K, Roemer H. Factor X Aktivität bei ausgetragenen Neugeborenen und ihre Beeinflußbarkeit durch Vitamin K1 . Gynaecologia (Basel) 152: 183 1961;
    PubMedSearch in Google Scholar
  • 6 Biggs R, Macfarlane R. G. Human Blood Coagulation and its Disorders. 3rd Edition.. Black-well Scientific Publications; Oxford: 1962
    Search in Google Scholar
  • 7 Brinkhous K. M, Smith H. P, Warner E. D. Plasma prothrombin level in normal infancy and in hemorrhagic disease of the newborn. Amer. J. med. Sci 193: 475 1937;
    CrossrefPubMedSearch in Google Scholar
  • 8 Crane M. M, Sanford H. N. Substances involved in the coagulation of the blood of the newborn infant. IV. Variations in the fibrinogen content in the normal infant. Amer. J. Dis. Child 52: 99 1936;
    PubMedSearch in Google Scholar
  • 9 Denson K. W. The specific assay of Prower-Stuart factor and factor VII. Acta haemat. (Basel) 25: 105 1961;
    CrossrefPubMedSearch in Google Scholar
  • 10 Douglas A. S, Davies P. Hypoprothrombinanemia in the newborn. Arch. Dis. Child 30: 509 1955;
    CrossrefPubMedSearch in Google Scholar
  • 11 Dyggve H. Prothrombin and proconvertin in the newborn and during the first year of life. Actapaediat. (Uppsala) 47: 251 1958;
    PubMedSearch in Google Scholar
  • 12 Egeberg O. The effect of unspecific fever induction on the blood clotting system. Scand. J. clin. Lab. Invest 14: 471 1962;
    CrossrefPubMedSearch in Google Scholar
  • 13 Egeberg O. The effect of exercise on the blood clotting system. Scand. J. clin. Lab. Invest 15: 8 1963;
    CrossrefPubMedSearch in Google Scholar
  • 14 Egeberg O. On the nature of the blood antihemophilic A factor (AHA = F.VIII) increase associated with muscular exercise. Scand. J. clin. Lab. Invest 15: 202 1963;
    CrossrefPubMedSearch in Google Scholar
  • 15 Ellis B. C, Stransky A. A quick and accurate method for the determination of fibrinogen in plasma. J. Lab. clin. Med 58: 477 1961;
    PubMedSearch in Google Scholar
  • 16 Foster D. P. A clinical study of blood fibrin. Arch, intern. Med 34: 301 1924;
    CrossrefPubMedSearch in Google Scholar
  • 17 Fresh J. W, Ferguson J. H, Lewis J. H. Blood clotting studies in parturient women and the newborn. Obstet, and Gynaec 7: 117 1956;
    PubMedSearch in Google Scholar
  • 18 Fresh J. W, Ferguson J. H, Stamey G, Morgan F. M, Lewis J. H. Blood prothrombin, proconvertin and proaccelerin in normal infancy: Questionable relationships to vit. K. Pediatrics 19: 241 1957;
    PubMedSearch in Google Scholar
  • 19 Gillman T, Naidoo S. S, Hathorn M. Plasma fibrinogen activity in pregnancy. Lancet II: 70 1959;
    PubMedSearch in Google Scholar
  • 20 Gram H. G. On the causes of the variations in the sedimentation of the corpuscles and the formation of the Crusta Phlogistica (“Size”, “Buffy Coat”) on the blood. Arch, intern. Med 25: 312 1921;
    PubMedSearch in Google Scholar
  • 21 Grossman B. J, Heyn R. M, Rozenfeld I. H. Coagulation studies in the newborn infant. 1. Normal infants. Pediatrics 9: 182 1952;
    PubMedSearch in Google Scholar
  • 22 Hartmann J. R, Howell D. A, Diamond L. K. Disorders of blood coagulation during the first of life. Amer. J. Dis. Child 90: 594 1955;
    PubMedSearch in Google Scholar
  • 23 Hilgartner M. W, Smith G. H. Plasma thromboplastin antecedent (Factor XI) levels in the neonate. J. Pediat 66: 747 1965;
    CrossrefPubMedSearch in Google Scholar
  • 24 Ingram G. I. C. Increase in antihaemophilic globulin activity following infusion of adrenaline. J. Physiol. (Lond.) 156: 217 1961;
    CrossrefPubMedSearch in Google Scholar
  • 25 Ingram G. I. G. In Brinkhous K. M. (Ed.) The Hemophilias. University of North Carolina Press; 1964: 243.
    Search in Google Scholar
  • 26 Kennan A. L. Coagulation defects in obstetric accidents and disorders. Amer. J”. med. Sci 229: 695 1955;
    PubMedSearch in Google Scholar
  • 27 Künzer W, Lütgemeier J. Zur entwicklungsbedingten Abhängigkeit des Plasmagehaltes an Fibrin-stabilisierendem Faktor (FSF). Ann. Paediat 204: 232 1965;
    PubMedSearch in Google Scholar
  • 28 Kurkcuoglu M, McElfresh A. E. The Hageman factor: Determination of its concentration during the neonatal period and presentation of a case of Hageman factor deficiency. J. Paediat 57: 61 1960;
    CrossrefPubMedSearch in Google Scholar
  • 29 Larrieu M. J, Soldier J. P, Minkowski A. Le sang du cordon omblical: Etude complete de sa coagulabilite, comparison avec le sang maternel. Étud. neonat 1: 1 1952;
    PubMedSearch in Google Scholar
  • 30 Loeliger A, Koller F. Behavior of factor VII and prothrombin in late pregnancy and in newborn. Actahaemat. (Basel) 7: 157 1952;
    PubMedSearch in Google Scholar
  • 31 Lorand L, Jacobsen A. Studies on the polymerization of fibrin: The role of the globulin: fibrin-stabilizing factor. J. biol. Chem 230: 421 1958;
    PubMedSearch in Google Scholar
  • 32 McElfresh A. E, Sharpsteen J. R, Akabane T. The generation of thromboplastin and levels of plasma thromboplastin component in the blood of infants. Pediatrics 17: 870 1956;
    PubMedSearch in Google Scholar
  • 33 Nossel H. L. The Contact Phase of Blood Coagulation. Blackwell Scientific Publications; Oxford: 1964
    Search in Google Scholar
  • 34 Nossel H. L. Unpublished observations 1965
    PubMed
  • 35 Nossel H. L, Niemetz J. The celite eluate test for assaying Factor XI (PTA). Fed. Proc 24: 452 1965;
    PubMedSearch in Google Scholar
  • 36 Owen G. A, Hoffman G. R, Ziffren S. E, Smith H. P. Blood coagulation during infancy. Proc. Soc. exp. Biol. (N. Y.) 41: 181 1939;
    CrossrefPubMedSearch in Google Scholar
  • 37 Owen C. A, Hum M. M. Changes in blood coagulation factors during the first week of life. J. Pediat 42: 424 1953;
    CrossrefPubMedSearch in Google Scholar
  • 38 Pechet L, Alexander B. Increased clotting factors in pregnancy. New Engl. J. Med 265: 1093 1961;
    CrossrefPubMedSearch in Google Scholar
  • 39 Plass E. D, Mathew C. W. Plasma protein fractions in normal pregnancy, labor and Puerperium. Amer. J. Obstet. Gynec 12: 346 1926;
    CrossrefPubMedSearch in Google Scholar
  • 40 Preston A. E. The plasma concentration of factor VIII in the normal population. 1. Mothers and babies at birth. Brit. J. Haemat 10: 110 1964;
    PubMedSearch in Google Scholar
  • 41 Rapaport S. I, Schiffman S, Patch M. J, Ames S. B. The importance of activation of antihemophilic globulin and proaccelerin by traces of thrombin in the generation of intrinsic prothrombinase activity. Blood 21: 221 1963;
    PubMedSearch in Google Scholar
  • 42 Rapaport M, Rubin M. I, Chaffee D. Fractionation of the serum and plasma proteins by salt precipitation in infants and children. J. clin. Invest 22: 487 1943;
    CrossrefPubMedSearch in Google Scholar
  • 43 Ratnoff O. D, Colopy J. E, Pritchard J. A. The blood clotting mechanism during normal parturition. J. Lab. clin. Med 44: 408 1954;
    PubMedSearch in Google Scholar
  • 44 Ratnoff O. D, Holland T. R. Coagulation components in normal and abnormal pregnancies. Ann. N. Y. Acad. Sci 75: 626 1958;
    PubMedSearch in Google Scholar
  • 45 Rizza C. R. Effect of exercise on the level of antihaemophilic globulin in human blood. J. Physiol. (Lond.) 156: 128 1961;
    CrossrefPubMedSearch in Google Scholar
  • 46 Rush A. A comparison of the fibrinogen and prothrombin levels of maternal and cord blood at delivery. Surg. Gynec. Obstet 70: 922 1940;
    PubMedSearch in Google Scholar
  • 47 Schulz J, van Creveld S. Stuart-Prower factor in newborn infants. Étud. neonat 7: 133 1958;
    PubMedSearch in Google Scholar
  • 48 Shepherd I. A study of the effects of vitamin K upon neonatal survival in African and Indian patients. S. Af. med. J 33: 945 1959;
    PubMedSearch in Google Scholar
  • 49 Strauss H. S, Diamond L. K. Elevation of factor VIII (antihemophilic factor) during pregnancy in normal persons and in a patient with von Willebrand’s disease. New Engl. J. Med 269: 1251 1963;
    CrossrefPubMedSearch in Google Scholar
  • 50 Taylor P. M. Concentration of fibrinogen in the plasma of normal newborn infants. Pediatrics 19: 233 1957;
    PubMedSearch in Google Scholar
  • 51 van Creveld S, Nagel C. G. M, Nigenhurs J. J, Smit S. Thromboplastic function in the blood of the newborn. Étud. neonat 3: 135 1954;
    PubMedSearch in Google Scholar