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DOI: 10.1055/s-0037-1622140
Ätiologie sekundärer Lymphödeme onkologischer Genese[*]
LiteraturreviewAetiology of secondary lymphoedema of oncologic originEtiologie des lymphoedèmes secondaires d’origine cancéreuse. Revue de la littératurePublikationsverlauf
Eingegangen:
13. März 2006
angenommen mit Revision:
12. April 2006
Publikationsdatum:
02. Januar 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00034913/200603/lookinside/thumbnails/10-1055-s-0037-1622140_de-1.jpg)
Zusammenfassung
Neoplasien stellen eine wichtige Ursache für sekundäre Lymphödeme dar. Dabei kann der Tumor selbst (malignes Lymphödem) oder seine Therapie das Lymphödem auslösen. Die wichtigsten Neoplasien im Hinblick auf Lymphödeme betreffen – in absteigender absoluter Lymphödem-Inzidenz – die Mamma, die Prostata, die Haut (Melanom), das Ovar und die Harnblase. Jedoch können auch zahlreiche andere Tumore direkt oder indirekt ein sekundäres Lymphödem auslösen. Ganz klar erkennbar ist, dass mit der Radikalität der Therapien die Inzidenz von Lymphödemen zunimmt; Daten für einen Zusammenhang mit dem Schweregrad fehlen jedoch. Bei zunehmenden Überlebensraten steigt daher die Prävalenz von Patentinnen und Patienten mit einem Lymphödem mit physischen und/oder psychischen Beschwerden und Einschränkungen im Erwerbsund/oder Privatleben.
Summary
Malignancies are among the major reasons for secondary lymphoedema. On the one side, the tumour itself can induce the lymphoedema or, on the other side, the applied therapy. The most important malignancies – in descending order of the absolute incidence of lymphoedema – are tumours of the (female) breast, the prostate, the skin (melanoma), the ovaries and the bladder. Of course, several other malignancies can also induce lymphoedema, either directly or indirectly. It is evident that the incidence is directly coupled with the radicalism of the therapy applied; nevertheless, data dealing with the relation of the severity of the lymphoedema and the therapy are missing. With increasing survival rates the prevalence of lymphoedema-patients with physical and/or psychical complains and restrictions within their professional and even their private life is rising.
Résumé
Les tumeurs malignes sont les premières causes de lymphoedèmes secondaires. D’une part, la tumeur elle-même peut provoquer un lymphoedème et d’autre part celui-ci peut être induit par le traitement de la tumeur. Les tumeurs malignes les plus fréquentes – en ordre décroissant pour l’apparition d’un lymphoedème – concernent le sein (chez la femme), la prostate, la peau (mélanome), l’ovaire et la vessie. Il est évident que beaucoup d’autres tumeurs malignes peuvent induire un lymphoedème, de manière directe ou indirecte. Le degré d’agressivité d’un traitement est également en relation directe avec l’apparition d’un lymphoedème ; néanmoins, on manque de données pour établir une relation entre la gravité d’un lymphoedème et la thérapie. On peut souligner que l’augmentation de la survie après traitement montre un parallèle avec l’accroissement des plaintes des patients sur le plan physique ou psychique concernant les restrictions de leur vie privée et professionnelle.
* Die gegenständliche Arbeit entstand aus dem ersten Teil einer Dissertationsarbeit, die an der Division für klinisch-funktionelle Anatomie, Department für Anatomie, Histologie und Embryologie, der Medizinischen Universität Innsbruck erstellt wurde (85).
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Literatur
- 1 Albert US, Wagner U, Kalder M. et al. Lymphödem bei Mammakarzinom: Regionale Konsensus-Empfehlungen zum postoperativen Management, Prävention, Therapie und Nachsorge. Geburtshilfe und Frauenheilkunde 2005; 65: 955-65.
- 2 Ameen M, Kwan J, Mortimer PS. Metastatic eccrine porocarcinoma presenting with lymphoedema. Br J Dermatol 2004; 150: 607-9.
- 3 Arcuri V, Ardoino S, Ceppa P. et al. Linfedema degli arti inferiori secondario a linfangite neoplastica da adenocarcinoma muciparo dello stomaco. Osservazione di due casi. Minerva Chir 1988; 43: 2103-6.
- 4 Armer J, Fu MR, Wainstock JM. et al. Lymphedema following breast cancer treatment, including sentinel lymph node biopsy. Lymphology 2004; 37: 73-91.
- 5 Badr el Din A, Coibion M, Guenier C. et al. Local postoperative morbidity following pre-operative irradiation in locally advanced breast cancer. Eur J Surg Oncol 1989; 15: 486-9.
- 6 Baer S, Schreiner WE. Inguinale Lymphome mit Beinschwellung als Leitsymptome des Tubenkarzinoms. Gynakol Rundsch 1989; 29 (Suppl. 01) 23-8.
- 7 Bazex A, Dupre A, Cantala P. et al. Lymphoedeme du visage ayant precede de 2 ans la decouverte d’un sarcoma de l’amygdale. Bull Soc Fr Dermatol Syphiligr 1969; 76: 535-6.
- 8 Beigel Y, Zelikovski A, Shimoni S. et al. Chylous ascites as a presenting sign of prostatic adenocarcinoma. Lymphology 1990; 23: 183-6.
- 9 Bilek K, Ebeling K, Leitsmann H. et al. Zur Problematik der Nachbestrahlung beim radikal operierten Zervixkarzinom im Stadium T1b N0 M0. Vorläufige Ergebnisse eines randomisierten klinischen Versuches. Zentralbl Gynäkol 1981; 103: 1014-22.
- 10 Blom A, Kolb F, Lumbroso J. et al. Interet du ganglion sentinelle dans le carcinome de Merkel. Analyse de 11 cas. Ann Dermatol Venereol 2003; 130: 417-22.
- 11 Bosze P, Meszaros I, Palfalvi L. et al. Perioperative complications of 116 radical hysterectomies and pelvic node dissections. Eur J Surg Oncol 1993; 19: 605-8.
- 12 Browse NL, Wilson NM, Russo F. et al. Aetiology and treatment of chylous ascites. Br J Surg 1992; 79: 1145-50.
- 13 Carvalho JP, Souen JS, Carramao Sda S. et al. Wertheim-Meigs radical hysterectomy. Sao Paulo Med J 1994; 112: 539-42.
- 14 Cavanagh D, Fiorica JV, Hoffman MS. et al. Invasive carcinoma of the vulva. Changing trends in surgical management. Am J Obstet Gynecol 1990; 163: 1007-15.
- 15 Chwirot R. Olbrzymi oponiak oczodolu z wtorna sloniowacizna powiek. Klin Oczna 1976; 46: 447-51.
- 16 Clark PB. Radical cystectomy for carcinoma of the bladder. Br J Urol 1978; 50: 492-5.
- 17 Clark R, Wasilewska T, Carter J. Lymphoedema: a study of Otago women treated for breast cancer. Nurs Prax N Z 1997; 12: 4-15.
- 18 Cottafava F, Cosso D, Brida di Prio S. et al. Un caso di sclerosi tuberosa di Bourneville con elefantiasi (per linfedema) all’arto inferiore sinistro. Minerva Pediatr 1986; 38: 49-52.
- 19 Deo SV, Ray S, Rath GK. et al. Prevalence and risk factors for development of lymphedema following breast cancer treatment. Indian J Cancer 2004; 41: 8-12.
- 20 Doublet JD, Gattegno B, d’Acremont B. et al. Curage lymphatique iliaque sous-veineux par coelioscopie pour le bilan des cancers prostatiques (16 patients). Prog Urol 1992; 2: 980-6.
- 21 Dunne-Daly CF. Potential long-term and late effects from radiation therapy. Cancer Nurs 1995; 18: 67-78.
- 22 Edwards TL. Prevalence and aetiology of lymphoedema after breast cancer treatment in southern Tasmania. Aust N Z J Surg 2000; 70: 412-8.
- 23 Engel K, Muller A, Anton W. et al. Nebenwirkungen und Komplikationen bei der brusterhaltenden Therapie des Mammakarzinoms. Geburtshilfe Frauenheilkd 1989; 49: 367-74.
- 24 Enig B, Mogensen M, Jorgensen RJ. Lymfodem hos patienter behandlet for brystkraeft. En tvaersnitsundersogelse i Ribe Amt. Behovet for manuel lymfedraenage; risikofaktorer. Ugeskr Laeger 1999; 161: 3293-8.
- 25 Ewald H. Strahlentherapie bei HNO-Tumoren und Lymphödemrisiko. Z Lymphol 1996; 20: 21-6.
- 26 Fagone S, Cavaleri A, Camuto M. et al. Sarcoma di Kaposi i ipercheratosico con linfedema della gamba dopo prolungata terapia corticosteroidea per LES. Caso clinico e rassegna della letteratura. Minerva Med 2001; 92: 177-202.
- 27 Fass R, Haddad M, Sandbank Y. et al. Retroperitoneal liposarcoma presenting with bilateral leg lymphedema – case report. Vasa 1990; 19: 334-5.
- 28 Ferlay J, Bray F, Pisani P. et al. GLOBOCAN 2002 – Cancer Incidence, Mortality and Prevalence Worldwide. In: IARC CancerBase No. 5, version 2.0 ed. Lyon: IARCPress; 2004
- 29 Ferrandez JC, Serin D, Bouges S. Frequence des lymphoedemes du membre superieur apres traitement du cancer du sein. Facteurs de risque. A propos de 683 observations. Bull Cancer 1996; 83: 989-95.
- 30 Ferraris G, Lanza A, D’Addato F. et al. Complications of axillary, inguinal, pelvic and para-aortic lymphadenectomy. Eur J Gynaecol Oncol 1988; 9: 130-5.
- 31 Fiorica JV, Roberts WS, Greenberg H. et al. Morbidity and survival patterns in patients after radical hysterectomy and postoperative adjuvant pelvic radiotherapy. Gynecol Oncol 1990; 36: 343-7.
- 32 Fortner JG, Kim DK, Shiu MH. Limb-preserving vascular surgery for malignant tumors of the lower extremity. Arch Surg 1977; 112: 391-4.
- 33 Gaarenstroom KN, Kenter GG, Trimbos JB. et al. Postoperative complications after vulvectomy and inguinofemoral lymphadenectomy using separate groin incisions. Int J Gynecol Cancer 2003; 13: 522-7.
- 34 Gerdin E, Cnattingius S, Johnson P. Complications after radiotherapy and radical hysterectomy in early-stage cervical carcinoma. Acta Obstet Gynecol Scand 1995; 74: 554-61.
- 35 Gobbeler T, Lohr E, Magnus L. et al. Elefanthiasis bei Neurofibromatose von Recklinghausen. Arteriographische, phlebographische, lymphangiographische und histologische Befunde. Fortschr Geb Rontgenstr Nuklearmed 1969; 111: 38-42.
- 36 Gould N, Kamelle S, Tillmanns T. et al. Predictors of complications after inguinal lymphadenectomy. Gynecol Oncol 2001; 82: 329-32.
- 37 Greskovich FJ, Zagars GK, Sherman NE. et al. Complications following external beam radiation therapy for prostate cancer: an analysis of patients treated with and without staging pelvic lymphadenectomy. J Urol 1991; 146: 798-802.
- 38 Gunduz K, Shields JA, Shields CL. et al. Cutaneous angiosarcoma with eyelid involvement. Am J Ophthalmol 1998; 125: 870-1.
- 39 Haberthur F, Almendral AC, Ritter B. Therapy of vulvar carcinoma. Eur J Gynaecol Oncol 1993; 14: 218-27.
- 40 Hagen B, Skjeldestad FE, Tingulstad S. et al. Kirurgisk behandling av cancer cervicis uteri. Et seksarsmateriale fra et regionsykehus. Tidsskr Nor Laegeforen 1994; 114: 2603-5.
- 41 Harjola PT, Ketonen P, Luosto R. Desmoid tumour compressing vital pelvic structures. A case report. Ann Chir Gynaecol 1977; 66: 203-5.
- 42 Herpertz U. Das maligne Lymphödem. Z Lymphol 1990; 14: 17-23.
- 43 Herpertz U. Ödeme und Lymphdrainage. Stuttgart: Schattauer; 2003
- 44 Heyn R, Raney Jr RB, Hays DM. et al. Late effects of therapy in patients with paratesticular rhabdomyosarcoma. Intergroup Rhabdomyosarcoma Study Committee. J Clin Oncol 1992; 10: 614-23.
- 45 Hoe AL, Iven D, Royle GT. et al. Incidence of arm swelling following axillary clearance for breast cancer. Br J Surg 1992; 79: 261-2.
- 46 Hojris I, Andersen J, Overgaard M. et al. Late treatment-related morbidity in breast cancer patients randomized to postmastectomy radiotherapy and systemic treatment versus systemic treatment alone. Acta Oncol 2000; 39: 355-72.
- 47 Hong JH, Tsai CS, Lai CH. et al. Postoperative low-pelvic irradiation for stage I-IIA cervical cancer patients with risk factors other than pelvic lymph node metastasis. Int J Radiat Oncol Biol Phys 2002; 53: 1284-90.
- 48 Honore LH. Anal gland adenocarcinoma presenting as painless scrotal swelling in a 73-yearold man: a case report. J Surg Oncol 1980; 15: 201-7.
- 49 Hoskin PJ, Hanks GW. The management of symptoms in advanced cancer: experience in a hospitalbased continuing care unit. J R Soc Med 1988; 81: 341-4.
- 50 Huet P, Dandurand M, Pignodel C. et al. Metastasizing eccrine porocarcinoma: report of a case and review of the literature. J Am Acad Dermatol 1996; 35: 860-4.
- 51 Hughes TM, A’Hern RP, Thomas JM. Prognosis and surgical management of patients with palpable inguinal lymph node metastases from melanoma. Br J Surg 2000; 87: 892-901.
- 52 Hughes TM, Thomas JM. Combined inguinal and pelvic lymph node dissection for stage III melanoma. Br J Surg 1999; 86: 1493-8.
- 53 Ingvar C, Erichsen C, Jonsson PE. Morbidity following prophylactic and therapeutic lymph node dissection for melanoma--a comparison. Tumori 1984; 70: 529-33.
- 54 Institute for Scientific Information. Web of Science ®. http://portal.isiknowledge.com/portal.cgi?DestApp=WOS&Func=Frame (last access: 2005–10–18)
- 55 Jakab F, Baranyai L, Baranyai Z. et al. Lymphadenectomy in gastrointestinal surgery for malignancy. Acta Chir Hung 1997; 36: 141-2.
- 56 James JH. Lymphoedema following ilio-inguinal lymph node dissection. Scand J Plast Reconstr Surg 1982; 16: 167-71.
- 57 Karakousis CP, Driscoll DL. Groin dissection in malignant melanoma. Br J Surg 1994; 81: 1771-4.
- 58 Katsohi D, Krenkel B, Schmachtenberg A. et al. Zehnjährige Erfahrungen mit einer innovativen Bestrahlungstechnik beim Mammakarzinom. Analyse der Spätfolgen am Normalgewebe. Strahlenther Onkol 1995; 171: 649-54.
- 59 Kauffman CL, Sina B. Metastatic inflammatory carcinoma of the rectum: tumor spread by three routes. Am J Dermatopathol 1997; 19: 528-32.
- 60 Kavoussi LR, Sosa E, Chandhoke P. et al. Complications of laparoscopic pelvic lymph node dissection. J Urol 1993; 149: 322-5.
- 61 Keenan JM, Elliott AJ. Adenocarcinoma: an unusual presentation. Ann Ophthalmol 1991; 23: 137-8.
- 62 Kissin MW, Querci della Rovere G, Easton D. et al. Risk of lymphoedema following the treatment of breast cancer. Br J Surg 1986; 73: 580-4.
- 63 Kröll A, Neuhüttler S, Brenner E. Ätiologie und Epidemiologie des primären Lymphödems. Phlebologie 2006; 35: 3-10.
- 64 Langfritz K, Grabbe S, Kovacs G. et al. Metastasierendes ekkrines Porokarzinom. Hautarzt 1993; 44: 176-9.
- 65 Lerner R, Requena R. Upper extremity lymphedema secondary to mammary cancer treatment. Am J Clin Oncol 1986; 9: 481-7.
- 66 Lieskovsky G, Skinner DG, Weisenburger T. Pelvic lymphadenectomy in the management of carcinoma of the prostate. J Urol 1980; 124: 635-8.
- 67 Lin JY, DuBeshter B, Angel C. et al. Morbidity and recurrence with modifications of radical vulvectomy and groin dissection. Gynecol Oncol 1992; 47: 80-6.
- 68 Lober CW, Haas BD. Massive periorbital lymphedema after excision of cutaneous malignancy. South Med J 1998; 91: 411-2.
- 69 Logan V. Incidence and prevalence of lymphoedema: a literature review. J Clin Nurs 1995; 4: 213-9.
- 70 Logue JP, Hale RJ, Wilcox FL. et al. Carcinoma of the cervix: an analysis of prognostic factors, treatment and patterns of failure following Wertheims hysterectomy. Int J Gynecol Cancer 1992; 2: 323-7.
- 71 Lotze W, Richter P. Sekundäre Lymphödeme bei gynäkologischen Malignomen. Zentralbl Gynäkol 1989; 111: 92-8.
- 72 Mack LA, Temple WJ, DeHaas WG. et al. Groin soft tissue tumors – a challenge for local control and reconstruction: a prospective cohort analysis. J Surg Oncol 2004; 86: 147-51.
- 73 Magrina JF. Primary surgery for stage IB-IIA cervical cancer, including short-term and long-term morbidity and treatment in pregnancy. J Natl Cancer Inst Monogr 1996; 21: 53-9.
- 74 Martimbeau PW, Kjorstad KE, Kolstad P. Stage IB carcinoma of the cervix, the Norwegian Radium Hospital, 1968–1970: results of treatment and major complications. I. Lymphedema. Am J Obstet Gynecol 1978; 131: 389-94.
- 75 Martin Martinez JC, Herranz Amo F, Jara R. et al Complicaciones en las linfadenectomias inguinales por carcinoma del pene. Origen, manejo y prevencion. Actas Urol Esp 1995; 19: 759-71.
- 76 Martorell F. Lymphedema of the arm as an indicator of an occult carcinoma of the breast. Angiologia 1962; 14: 199-201.
- 77 Martorell F. Linfedema tumorigénico. Cir Ginecol Urol 1964; 18: 450-4.
- 78 Mazza A. Correlazioni patogenetiche fra edema dell’arto inferiore e compressione ureterale nel cancro del collo dell’utero. Clin Ostet Ginecol 1963; 65: 649-56.
- 79 Meric F, Buchholz TA, Mirza NQ. et al. Long-term complications associated with breast-conservation surgery and radiotherapy. Ann Surg Oncol 2002; 9: 543-9.
- 80 Michelini S, Campisi C, Cavezzi A. et al. Studio epidemiologico nazionale sui linfedemi. Minerva Cardioangiol 1998; 46: 393-4.
- 81 Nagel PH, Bruggink ED, Wobbes T. et al. Arm morbidity after complete axillary lymph node dissection for breast cancer. Acta Chir Belg 2003; 103: 212-6.
- 82 National Center for Biotechnology Information. PubMed. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed (last access: 2005–10–18)
- 83 Nelson BA, Cookson MS, Smith Jr JA. et al. Complications of inguinal and pelvic lymphadenectomy for squamous cell carcinoma of the penis: a contemporary series. J Urol 2004; 172: 494-7.
- 84 Nesvold IL, Fossa SD. Lymfodem etter operativ behandling av cancer i cervix uteri og vulva. Tidsskr Nor Laegeforen 2002; 122: 2531-3.
- 85 Neuhüttler S. Beitrag zur Epidemiologie des Lymphödems. In: Department für Anatomie, Histologie und Embryologie. Innsbruck: Medizinische Universität Innsbruck; 2005
- 86 Niwinńska A, Tchórzewska H, Procner M. et al. The frequency and risk factors of developing lymphedema of the upper extremity after breast conserving therapy. Nowotwory 2005; 55: 213.
- 87 Nunns D, Williamson K, Swaney L. et al. The morbidity of surgery and adjuvant radiotherapy in the management of endometrial carcinoma. Int J Gynecol Cancer 2000; 10: 233-8.
- 88 ÖBIG. Versorgungssituation und Versorgungsbedarf von Lymphödempatienten: Endbericht. In: Österreichisches Bundesinstitut für Gesundheitswesen. (Hrsg) Wien: Österreichisches Bundesinstitut für Gesundheitswesen; 1999
- 89 Okeke AA, Bates DO, Gillatt DA. Lymphoedema in urological cancer. Eur Urol 2004; 45: 18-25.
- 90 Ornellas AA, Seixas AL, de Moraes JR. Analyses of 200 lymphadenectomies in patients with penile carcinoma. J Urol 1991; 146: 330-2.
- 91 Ozaslan C, Kuru B. Lymphedema after treatment of breast cancer. Am J Surg 2004; 187: 69-72.
- 92 Paci E, Cariddi A, Barchielli A. et al. Long-term sequelae of breast cancer surgery. Tumori 1996; 82: 321-4.
- 93 Petereit DG, Mehta MP, Buchler DA. et al. Inguinofemoral radiation of N0,N1 vulvar cancer may be equivalent to lymphadenectomy if proper radiation technique is used. Int J Radiat Oncol Biol Phys 1993; 27: 963-7.
- 94 Petrek J, Senie R, Peters M. et al. Lymphedema in a cohort of breast carcinoma survivors 20 years after diagnosis. Cancer 2001; 92: 1368-77.
- 95 Petrek JA, Heelan MC. Incidence of breast carcinoma-related lymphedema. Cancer 1998; 83 (12 Suppl American) 2776-81.
- 96 Querci della Rovere G, Ahmad I, Singh P. et al. An audit of the incidence of arm lymphoedema after prophylactic level I/II axillary dissection without division of the pectoralis minor muscle. Ann R Coll Surg Engl 2003; 85: 158-61.
- 97 Reece GP, Gillis TA, Pollock RE. Lower extremity salvage after radical resection of malignant tumors in the groin and lower abdominal wall. J Am Coll Surg 1997; 185: 260-7.
- 98 Revilla J, Figares E. Metastasis cutanea tardia, secundaria a cancr mamario, de un antebrazo con linfoedema. Arch Cuba Cancerol 1957; 16: 207-11.
- 99 Rigas A, Kostakis A, Safioleas M. et al. Lymphedema as the first manifestation of Hodgkin’s disease. Lymphology 1981; 14: 138-40.
- 100 Roberts CC, Levick JR, Stanton AW. et al. Assessment of truncal edema following breast cancer treatment using modified Harpenden skinfold calipers. Lymphology 1995; 28: 78-88.
- 101 Robinson MH, Spruce L, Eeles R. et al. Limb function following conservation treatment of adult soft tissue sarcoma. Eur J Cancer 1991; 27: 1567-74.
- 102 Ruhe R, Brauer JW. Beinlymphödem nach kombinierter Strahlentherapie im Säuglingsalter wegen multipler Hämangiome. Z Lymphol 1996; 20: 40-2.
- 103 Ryan M, Stainton MC, Slaytor EK. et al. Aetiology and prevalence of lower limb lymphoedema following treatment for gynaecological cancer. Aust N Z J Obstet Gynaecol 2003; 43: 148-51.
- 104 Sarosi Z, Bosze P, Danczig A. et al. Kiterjesztett szemeremtest-es kornyeki nyirokcsomo-eltavolitas szovodmenyei 58 szemeremtestrak esete alapjan. Orv Hetil 1994; 135: 743-6.
- 105 Sauter ER, Eisenberg BL, Hoffman JP. et al. Postmastectomy morbidity after combination preoperative irradiation and chemotherapy for locally advanced breast cancer. World J Surg 1993; 17: 237-242.
- 106 Schünemann H, Willich N. Sekundäre Armlymphödeme nach Primärtherapie von Mammakarzinomen. Zentralbl Chir 1992; 117: 220-5.
- 107 Schünemann H, Willich N. Lymphödeme nach Mammakarzinom. Eine Studie über 5868 Fälle. Dtsch Med Wochenschr 1997; 122: 536-41.
- 108 Sener SF, Milos S, Feldman JL. et al. The spectrum of vascular lesions in the mammary skin, including angiosarcoma, after breast conservation treatment for breast cancer. J Am Coll Surg 2001; 193: 22-8.
- 109 Sener SF, Winchester DJ, Martz CH. et al. Lymphedema after sentinel lymphadenectomy for breast carcinoma. Cancer 2001; 92: 748-52.
- 110 Senofsky GM, Moffat Jr FL, Davis K. et al. Total axillary lymphadenectomy in the management of breast cancer. Arch Surg 1991; 126: 1336-41.
- 111 Shipley WU, Kopelson G, Novack DH. et al. Preoperative irradiation, lymphadenectomy and 125iodine implant for patients with localized prostatic carcinoma: a correlation of implant dosimetry with clinical results. J Urol 1980; 124: 639-42.
- 112 Siegel BM, Mayzel KA, Love SM. Level I and II axillary dissection in the treatment of early-stage breast cancer. An analysis of 259 consecutive patients. Arch Surg 1990; 125: 1144-7.
- 113 Sivanesaratnam V, Sen DK, Jayalakshmi P. et al. Radical hysterectomy and pelvic lymphadenectomy for early invasive cancer of the cervix – 14-year experience. Int J Gynecol Cancer 1993; 3: 231-8.
- 114 Snijders-Keilholz A, Hellebrekers BW, Zwinderman AH. et al. Adjuvant radiotherapy following radical hysterectomy for patients with early-stage cervical carcinoma (1984–1996). Radiother Oncol 1999; 51: 161-7.
- 115 Soto Delgado M, Arredondo Martinez F, Pedrero Marquez G. et al. Cancer de pene. Una revision de 18 casos. Actas Urol Esp 2003; 27: 797-802.
- 116 Sparaco A, Fentiman IS. 9. Arm lymphoedema following breast cancer treatment. Int J Clin Pract 2002; 56: 107-10.
- 117 Spittell Jr JA, Smith RD, Harrison Jr EG. et al. Unilateral secondary lymphedema: a clue to malignant disease. Mayo Clin Proc 1963; 38: 139-44.
- 118 Stahlberg CI, Jorgensen T. Armmorbiditet efter aksildissektion for cancer mammae. Ugeskr Laeger 2001; 163: 3356-9.
- 119 Stambuk J, Oddo D, Perez R. et al. Leiomiosarcoma de vena safena. Rev Med Chil 1993; 121: 673-6.
- 120 Starritt EC, Joseph D, McKinnon JG. et al. Lymphedema after complete axillary node dissection for melanoma: assessment using a new, objective definition. Ann Surg 2004; 240: 866-74.
- 121 Stevens G, Thompson JF, Firth I. et al. Locally advanced melanoma: results of postoperative hypofractionated radiation therapy. Cancer 2000; 88: 88-94.
- 122 Suceava I, Mircea L. Manifestarile edematoase in cancerul laringian. Otorinolaringologie 1968; 13: 33-40.
- 123 Taylor ME. Lymphedema secondary to postmastectomy radiation: Incidence and risk factors. Breast Diseases 2005; 16: 69.
- 124 Tengrup I, Nittby LT, Christiansson I. et al. Armbesvar vanliga efter brostoperation. Lymfodem drabbar ofta aldre brostcancerbehandlade kvinnor. Lakartidningen 1999; 96: 5089-91.
- 125 Tinger A, Waldron T, Peluso N. et al. Effective palliative radiation therapy in advanced and recurrent ovarian carcinoma. Int J Radiat Oncol Biol Phys 2001; 51: 1256-63.
- 126 Tsunematsu Y, Koide R, Watanabe S. et al. A clinicopathological study of histiocytosis X. Jpn J Clin Oncol 1984; 14: 633-46.
- 127 Tsyb AF, Bardychev MS, Guseva LI. Secondary limb edemas following irradiation. Lymphology 1981; 14: 127-32.
- 128 Van Dam MS, Hennipman A, de Kruif JT. et al. Complicaties na okselkliertoilet wegens mammacarcinoom. Ned Tijdschr Geneeskd 1993; 137: 2395-8.
- 129 Wedgwood KR, Benson EA. Non-tumour morbidity and mortality after modified radical mastectomy. Ann R Coll Surg Engl 1992; 74: 314-7.
- 130 Werngren-Elgstrom M, Lidman D. Lymphoedema of the lower extremities after surgery and radiotherapy for cancer of the cervix. Scand J Plast Reconstr Surg Hand Surg 1994; 28: 289-93.