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Thromb Haemost 1998; 79(06): 1126-1129
DOI: 10.1055/s-0037-1615028
Rapid Communication
Schattauer GmbH

Polymorphism of the Platelet Glycoprotein IIIa Gene in Patients with Coronary Stenosis

Miguel Garcia-Ribes
1   From the Nutrition and Cardiovascular Risk Unit, Spain
,
Domingo Gonzalez-Lamuño
1   From the Nutrition and Cardiovascular Risk Unit, Spain
,
Rafael Hernandez-Estefania
1   From the Nutrition and Cardiovascular Risk Unit, Spain
,
Thierry Colman
3   Hemodynamics Unit, Santander, Spain
,
Miguel Pocovi
5   Dept. of Biochemistry and Molecular Biology, University of Zaragoza, Spain
,
Miguel Delgado-Rodriguez
2   Division of Preventive Medicine and Public Health, University of Cantabria, Spain
,
Miguel Garcia-Fuentes
1   From the Nutrition and Cardiovascular Risk Unit, Spain
,
Jose M. Revuelta
1   From the Nutrition and Cardiovascular Risk Unit, Spain
4   Division of Cardiovascular Surgery, Hospital Universitario Marques de Valdecilla, Santander, Spain
› Institutsangaben
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Publikationsverlauf

Received 13. November 1997

Accepted after resubmission 24. Februar 1998

Publikationsdatum:
07. Dezember 2017 (online)

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Summary

Based on genetic variability, structural differences in the glycoprotein IIb/IIIa platelet receptor for adhesive proteins result in individual differences in the thrombogenicity of platelets. Recent studies suggest a controversial association between a genetic polymorphism of the glycoprotein IIIa gene (PlA2) and the risk of coronary artery disease. In our study, the prevalence of the PlA2 allele in a group of patients undergoing percutaneous coronary revascularization was 37%, a value significantly higher than in controls [13%, odds ratio (OR) = 3.93, 95% CI, 1.84 to 8.53] suggesting a significant association between this polymorphism and documented coronary stenosis, which is strongest among <60 years old patients (OR = 12.30, 95% CI, 2.98 to 70.93). This polymorphism represents an inherited risk factor for severe cardiovascular disease due to coronary occlusion.

 

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