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Thromb Haemost 1998; 79(06): 1096-1100
DOI: 10.1055/s-0037-1615022
Rapid Communication
Schattauer GmbH

Elevation of Serum Thrombopoietin Precedes Thrombocytosis in Kawasaki Disease

Akira Ishiguro
1   From the Department of Pediatrics, Mizonokuchi Hospital, Teikyo University School of Medicine, Kawasaki
,
Takashi Ishikita
1   From the Department of Pediatrics, Mizonokuchi Hospital, Teikyo University School of Medicine, Kawasaki
,
Toshikazu Shimbo
1   From the Department of Pediatrics, Mizonokuchi Hospital, Teikyo University School of Medicine, Kawasaki
,
Kousaku Matsubara
2   Department of Pediatrics, Nishi-Kobe Medical Center, Kobe
,
Kunizou Baba
2   Department of Pediatrics, Nishi-Kobe Medical Center, Kobe
,
Yasuhide Hayashi
3   Department of Pediatrics, Faculty of Medicine, The University of Tokyo, Tokyo
,
Shin-ichi Naritaka
3   Department of Pediatrics, Faculty of Medicine, The University of Tokyo, Tokyo
,
Tatsutoshi Nakahata
4   Department of Clinical Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
› Author Affiliations
Further Information

Publication History

Received 05 December 1997

Accepted after revision 09 February 1998

Publication Date:
07 December 2017 (online)

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Summary

Kawasaki disease (KD) is an acute systemic vasculitis causing coronary arterial aneurysms and myocardial infarction in young children. Prominent thrombocytosis with increased megakaryocytes develops during the convalescent period. To clarify the mechanisms of thrombocytosis, we studied serum levels of thrombopoietin (TPO) and other thrombopoietic cytokines in 40 patients with KD (149 samples) and 106 age-matched controls using ELISA. TPO values in the controls were 1.94 ± 0.69 fmol/ml (mean ± SD) with a 95% reference interval of 0.85 to 3.27 fmol/ml. In the first week of KD, platelet counts were normal but TPO values increased (~ 15.5 fmol/ml). TPO levels peaked on day 6 ± 2 at 5.94 ± 2.64 fmol/ml and then fell gradually. When platelet counts peaked in the second to third weeks, TPO levels were still high or comparable with the controls. TPO levels in KD patients with normal platelet counts were significantly higher than control levels. Interleukin (IL)-6 levels in the first week rose, but neither IL-11 nor leukemia inhibitory factor was detectable. These results suggest that TPO contributes to thrombocytosis in KD in conjunction with IL-6 and TPO production may be enhanced during the acute phase.

 

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