Platelet-vessel Wall Interactions with Third-generation Oral Contraceptives: No Evidence of Detrimental Effects

Franca Fruzzetti; Daniela Giannessi; Cabiria Ricci; Walter Bernini; Roberto Puntoni; Andrea Riccardo Genazzani; Raffaele De Caterina

doi:10.1055/s-0037-1614347

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1999; 82(03): 1164-1170
DOI: 10.1055/s-0037-1614347

Letters to the Editor

Schattauer GmbH

Platelet-vessel Wall Interactions with Third-generation Oral Contraceptives: No Evidence of Detrimental Effects

Franca Fruzzetti

²From the Department of Obstetrics and Gynecology, the University of Pisa, and C.N.R. Institute of Clinical Physiology, Pisa, Italy

,

Daniela Giannessi

¹C.N.R. Institute of Clinical Physiology, Pisa, Italy

,

Cabiria Ricci

²From the Department of Obstetrics and Gynecology, the University of Pisa, and C.N.R. Institute of Clinical Physiology, Pisa, Italy

,

Walter Bernini

¹C.N.R. Institute of Clinical Physiology, Pisa, Italy

,

Roberto Puntoni

¹C.N.R. Institute of Clinical Physiology, Pisa, Italy

,

Andrea Riccardo Genazzani

²From the Department of Obstetrics and Gynecology, the University of Pisa, and C.N.R. Institute of Clinical Physiology, Pisa, Italy

,

Raffaele De Caterina

¹C.N.R. Institute of Clinical Physiology, Pisa, Italy

› Author Affiliations

Abstract

Summary

Because of the association of oral contraceptives (OC) and cigarette smoking with an increased thrombotic risk, we evaluated thromboxane (TX) and prostacyclin urinary (u) metabolites, as in vivo indices of platelet-vessel wall interactions, in women assigned to third generation OC. Twenty-eight women (15 smokers) underwent a 6-month trial of 30 μg ethinylestradiol plus 0.150 mg desogestrel. Cotinine plasma levels were elevated only in persons classified as smokers and serum TXB₂ determination confirmed the absence of cyclooxygenase inhibition throughout the study. u-TXB₂ and 11-dehydro-TXB₂ were higher in smokers than in non-smokers. OC decreased u-11-dehydro-TXB₂ both in smokers (from (pg/μmol creatinine) 35.1 ± 6.9 to 15.8 ± 2.8; P <0.025) and non-smokers (from 31.7 ± 9.8 to 20.6 ± 4.8, P = N.S.). u-6-keto-prostaglandin(PG)F_1α excretion, also higher in smokers compared to non-smokers, was also reduced after OC in smokers (from (pg/μmol creatinine) 24.3 ± 5.2 to 14.8 ± 2.3; P <0.05). Smokers also had a trend to higher u-2,3-dinor-6-keto-PGF_1α, marginally reduced by OC.

Thus, the OC regimen used here improves – if anything – platelet vessel wall interactions as assessed by prostanoid production in vivo. The prothrombotic tendency associated with the use of OC in smokers does not appear to be mediated by changes in platelet-vessel wall interactions.

Key words

Oral contraceptive - ethinylestradiol - desogestrel - platelets - thromboxane - prostacyclin - urinary prostanoids - platelet-vessel wall interactions

Full Text

References

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