Vinylation of Benzylic Amines via C–N Bond Functionalization of Benzylic Pyridinium Salts

^‡ W.G. and J.L. are co-first authors.

Published as part of the Special Topic Modern Coupling Approaches and their Strategic Applications in Synthesis

Abstract

Cross-couplings of benzylic pyridinium salts and vinylboronic acids or esters have been developed. Via benzylic pyridinium intermediates, benzylic amines can be engaged in these cross-couplings through C–N bond functionalization. This method boasts mild reaction conditions and excellent tolerance for heteroaryl substituents and a range of functional groups.

Key words

allyl complexes - amines - benzylation - catalysis - cross-coupling - nickel

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