Pharmacopsychiatry 2017; 50(05): 213-227
DOI: 10.1055/s-0037-1606427
Abstracts
Georg Thieme Verlag KG Stuttgart · New York

sLORETA Neuroimaging study on Olanzapine I_focus on appetite

Y Abshir Ahmed
1   Sleep laboratory, Max- PLanck Institute of Psychiatry, Munich, Deutschland
,
P Beitinger
1   Sleep laboratory, Max- PLanck Institute of Psychiatry, Munich, Deutschland
,
A Steiger
1   Sleep laboratory, Max- PLanck Institute of Psychiatry, Munich, Deutschland
,
M Pawlowski
1   Sleep laboratory, Max- PLanck Institute of Psychiatry, Munich, Deutschland
› Institutsangaben
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Publikationsverlauf

Publikationsdatum:
12. September 2017 (online)

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Background:

Weight gain and increased appetite are major side effects of Olanzapine. We investigated the role of Brodmann area 25 (BA25), which participates in the regulation of autonomic and endocrine systems.

Methods:

10 healthy, young male subjects underwent two 118 channel sleep recordings i) at baseline and ii) after treatment with Olanzapine up to 10 mg for 7 days. We used artifact-free 5 min EEG clips from the first N3-sleep period for the EEG bands δ, θ, α, β1 (12.0 – 16.0 Hz) and β2 (16.0 – 20.0 Hz). Appetite was assessed by self-rating questionnaire.

Results:

We observed increases in total sleep time, in N3 and appetite. Furthermore, current source density of α- frequency band within BA 25 increased.

Discussion:

The increase in the current source density of α- frequency band in BA 25, suggests a specific effect of Olanzapine in autonomic and endocrine systems.