Synlett 2016; 27(16): 2314-2326
DOI: 10.1055/s-0035-1562784
account
© Georg Thieme Verlag Stuttgart · New York

Introduction of Functionalized Difluoromethylated Building Blocks Mediated or Catalyzed by Copper

Xavier Pannecoucke
Normandie Univ, INSA Rouen, UNIROUEN, CNRS, COBRA, (UMR 6014), 76000 Rouen, France   Email: thomas.poisson@insa-rouen.fr
,
Thomas Poisson*
Normandie Univ, INSA Rouen, UNIROUEN, CNRS, COBRA, (UMR 6014), 76000 Rouen, France   Email: thomas.poisson@insa-rouen.fr
› Author Affiliations
Further Information

Publication History

Received: 02 June 2016

Accepted after revision: 17 June 2016

Publication Date:
20 July 2016 (online)


Abstract

This account summarizes our recent progress on the copper-catalyzed direct introduction of functionalized difluoromethylated building blocks, and more particularly, the CF2CO2Et motif. We also discuss how this work led us to develop new copper-mediated methodologies to introduce the CF2PO(OR)2 motif, a valuable phosphate bioisostere.

1 Introduction

2 Copper-Catalyzed Introduction of the CF2CO2Et Residue

3 New Developments Toward the Introduction of the CF2PO(OEt)2 Motif

4 Conclusion and Outlook

 
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