Synthesis 2012; 44(19): 3015-3018
DOI: 10.1055/s-0032-1316761
paper
© Georg Thieme Verlag Stuttgart · New York

An Efficient Route to Difluoromethylated Pyridines

Kenichi Fujikawa
Department of Chemistry and Chemical Biology, Graduate School of Engineering, Gunma University, Kiryu, Gunma 376-8515, Japan, Fax: +81(277)301280   Email: amii@chem-bio.gunma-u.ac.jp
,
Akira Kobayashi
Department of Chemistry and Chemical Biology, Graduate School of Engineering, Gunma University, Kiryu, Gunma 376-8515, Japan, Fax: +81(277)301280   Email: amii@chem-bio.gunma-u.ac.jp
,
Hideki Amii*
Department of Chemistry and Chemical Biology, Graduate School of Engineering, Gunma University, Kiryu, Gunma 376-8515, Japan, Fax: +81(277)301280   Email: amii@chem-bio.gunma-u.ac.jp
› Author Affiliations
Further Information

Publication History

Received: 23 June 2012

Accepted: 25 June 2012

Publication Date:
06 August 2012 (online)


Abstract

A convenient route to difluoromethylated pyridines was developed that involves copper-promoted cross-coupling of halopyridines with ethyl difluoro(trimethylsilyl)acetate and subsequent decarboxylation.

 
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