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Synthesis 2012; 44(19): 3015-3018
DOI: 10.1055/s-0032-1316761
DOI: 10.1055/s-0032-1316761
paper
An Efficient Route to Difluoromethylated Pyridines
Further Information
Publication History
Received: 23 June 2012
Accepted: 25 June 2012
Publication Date:
06 August 2012 (online)
Abstract
A convenient route to difluoromethylated pyridines was developed that involves copper-promoted cross-coupling of halopyridines with ethyl difluoro(trimethylsilyl)acetate and subsequent decarboxylation.
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For the catalytic introduction of difluoroacetate moieties onto aryl rings, see: