Dehydrogenative Allylic Aminations of But-3-enoic Acid Derivatives

In memory of Professor Jean Normant: a great chemist, an extraordinary man.

Abstract

Two complementary Pd-catalyzed protocols enabling the γ-selective intermolecular allylic amination of but-3-enoic acid derivatives are reported. These transformations can be successfully achieved via either­ a direct Pd(II)-catalyzed protocol or by way of a one-pot Pd(II)/Pd(0)-catalyzed sequence, depending on the nature of the nitrogen nucleophile used.

Key words

palladium - catalysis - C–H activation - allylic amination - allylic acyloxylation - but-3-enoic acid derivatives

• References

• 1 Present address: Università degli Studi dell’Insubria, Como, Italy.
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