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DOI: 10.1055/s-0035-1561490
Organocatalytic Multicomponent Reactions of 1,3-Dicarbonyls for the Synthesis of Enantioenriched Heterocycles
Publication History
Received: 13 May 2016
Accepted after revision: 01 June 2016
Publication Date:
16 August 2016 (online)


‡ Both authors contributed equally to this study.
Abstract
In this feature article, a general perspective of the research program aimed towards the preparation of polycyclic heterocycles by the means of enantioselective organocatalytic multicomponent reactions is presented. Guidelines for reaction design, including the selection of substrates and organocatalysts are discussed. For all transformations, scope and limitations are presented, along with post-functionalization to afford diversified heterocyclic scaffolds.
1 Introduction
2 Type I Products: 1,4,5,6-Tetrahydropyridines
3 Type II Products: 1,2,3,4-Tetrahydropyridines
4 Type III Products: Bridged Perhydropyridines
5 Conclusion and Perspective
Key words
1,3-dicarbonyls - enantioselectivity - heterocycles - Michael addition - multicomponent reactions - organocatalysisSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1561490.
- Supporting Information