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DOI: 10.1055/s-0035-1561490
Organocatalytic Multicomponent Reactions of 1,3-Dicarbonyls for the Synthesis of Enantioenriched Heterocycles
Publikationsverlauf
Received: 13. Mai 2016
Accepted after revision: 01. Juni 2016
Publikationsdatum:
16. August 2016 (online)
![](https://www.thieme-connect.de/media/synthesis/201620/lookinside/thumbnails/ss-2016-z0349-fa_10-1055_s-0035-1561490-1.jpg)
‡ Both authors contributed equally to this study.
Abstract
In this feature article, a general perspective of the research program aimed towards the preparation of polycyclic heterocycles by the means of enantioselective organocatalytic multicomponent reactions is presented. Guidelines for reaction design, including the selection of substrates and organocatalysts are discussed. For all transformations, scope and limitations are presented, along with post-functionalization to afford diversified heterocyclic scaffolds.
1 Introduction
2 Type I Products: 1,4,5,6-Tetrahydropyridines
3 Type II Products: 1,2,3,4-Tetrahydropyridines
4 Type III Products: Bridged Perhydropyridines
5 Conclusion and Perspective
Key words
1,3-dicarbonyls - enantioselectivity - heterocycles - Michael addition - multicomponent reactions - organocatalysisSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1561490.
- Supporting Information
-
References
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For racemic versions, see:
For related reports, see:
For applications in enantioselective catalysis, see:
For examples of the advantage of microwave irradiation for the synthesis of 1,3-dicarbonyl compounds through ketoketene intermediates, see:
For other examples of combination of multicomponent reactions, see:
For recent reviews on organo- and metal-dual catalysis, see:
For related studies by other research groups, see:
For reviews on multicomponent reactions with isonitriles, see: