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Synthesis 2016; 48(05): 710-722
DOI: 10.1055/s-0035-1561288
DOI: 10.1055/s-0035-1561288
paper
Regio- and Stereoselective Synthesis of Benzo-δ-sultams by Palladium-Catalyzed Hydrocarbonation of Alkynes
Weitere Informationen
Publikationsverlauf
Received: 02. Oktober 2015
Accepted after revision: 20. November 2015
Publikationsdatum:
04. Januar 2016 (online)
![](https://www.thieme-connect.de/media/synthesis/201605/lookinside/thumbnails/ss-2015-z0579-op_10-1055_s-0035-1561288-1.jpg)
Abstract
An efficient method for the synthesis of benzo-δ-sultams [(4Z)-4-benzylidene-2-(arylmethyl)-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxides] via palladium(0)-catalyzed hydrocarbonation of alkynes is presented. This method allows regioselective access to a variety of substituted benzosultams in excellent yields under mild conditions. The stereochemistry of the exocyclic double bond of the benzosultam derivatives is confirmed by single-crystal X-ray diffraction.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1561288.
- Supporting Information
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