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Synthesis 2015; 47(21): 3423-3433
DOI: 10.1055/s-0034-1378734
DOI: 10.1055/s-0034-1378734
paper
Synthesis of Uracil-, Coumarin- and Quinolone-Fused Benzosultams and Benzosultones
Further Information
Publication History
Received: 26 March 2015
Accepted after revision: 28 May 2015
Publication Date:
30 July 2015 (online)
![](https://www.thieme-connect.de/media/synthesis/201521/lookinside/thumbnails/ss-2015-z0197-op_10-1055_s-0034-1378734-1.jpg)
Abstract
An efficient method for the regioselective synthesis of uracil-, coumarin- and quinolone-fused benzosultams and benzosultones is reported. The method offers a synthetic route to highly functionalized sultam and sultone derivatives in 75–95% yield under mild conditions. Density functional theory studies have been used to explain the regioselectivity in the synthesis of the coumarin- and quinolone-fused sultams and sultones.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1378734.
- Supporting Information
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For recent reviews on sultam chemistry, see:
For recent reviews on sultone chemistry, see: