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DOI: 10.1055/s-0034-1387626
Adipositas im Kindes- und Jugendalter
Obesity in Childhood and AdolescencePublication History
Publication Date:
28 April 2015 (online)
Zusammenfassung
Adipositas ist bereits im Kindes- und Jugendalter mit einer Vielzahl von kardiovaskulären Risikofaktoren assoziiert. Während diese meist asymptomatisch sind, leiden die adipösen Kinder v. a. unter den psychosozialen Folgen. Die Ursache der Adipositas im Kindesalter ist meist multifaktoriell und reicht von genetischen Faktoren über Umweltfaktoren bis hin zur familiären Situation. Bisherige Präventionskonzepte sind noch nicht nachhaltig überzeugend. Die Therapie der Wahl besteht aus einer Lebensstilintervention basierend auf Schulungsprogrammen. Misserfolge sind nicht nur auf fehlende Motivation, sondern auch auf die Gegenregulation des Körpers bei Gewichtsabnahme zurückzuführen. Die Therapie der extremen Adipositas im Jugendalter ist ein ungelöstes Problem, da Schulungsprogramme in der Regel nicht erfolgreich sind. Bariatrische Verfahren können zwar effektiv das Ausmaß des Übergewichts reduzieren, haben jedoch vielfältige Nebenwirkungen und benötigen eine lebenslange Betreuung, welche vor Beginn der Operation gewährleistet sein muss.
Abstract
Obesity in childhood and adolescence is associated with multiple cardiovascular risk factors. Most of them are asymptomatic and the obese children suffer from psychosocial consequences. The causes of obesity in childhood are mainly multi-factorial including beside others genetic factor, family stetting and environmental factors. Preventions concepts have failed so far to reduce effectively the prevalence of obesity. The treatment of choice is lifestyle intervention. Failures are not only caused by lack of motivation but also by counter regulation of body weight in weight loss. Therapy of extreme obese adolescents has not been solved. Bariatric surgery is able to reduce weight in these adolescents however, the complications and side effects have to be kept in mind. Furthermore, there is a need for a life-long medical care, which has to be guaranteed before surgery.
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Literatur
- 1 Ebbeling CB, Pawlak DB, Ludwig DS. Childhood obesity: public-health crisis, common sense cure. Lancet 2002; 360: 473-482
- 2 Biro FM, Wien M. Childhood obesity and adult morbidities. Am J Clin Nutr 2010; 91: 1499S-1505S
- 3 I'Allemand D, Wiegand S, Reinehr T et al. Cardiovascular risk in 26,008 European overweight children as established by a multicenter database. Obesity (Silver Spring) 2008; 16: 1672-1679
- 4 Arbeitsgemeinschaft Adipositas im Kindes- und Jugendalter. Guidelines of the German working group on obese children and adolescents. Im Internet: 2015. http://www.a-g-a.de/Leitlinie.pdf (Stand: 5.1.2015)
- 5 Kromeyer-Hauschild K, Wabitsch M, Geller F et al. Percentiles of body mass index in children and adolescents evaluated from different regional German studies. Monatsschr Kinderheilkd 2001; 149: 807-818
- 6 Kurth BM, Schaffrath RA. The prevalence of overweight and obese children and adolescents living in Germany. Results of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS). Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2007; 50: 736-743
- 7 Moss A, Klenk J, Simon K et al. Declining prevalence rates for overweight and obesity in German children starting school. Eur J Pediatr 2012; 171: 289-299
- 8 Cole TJ. The LMS method for constructing normalized growth standards. Eur J Clin Nutr 1990; 44: 45-60
- 9 Han JC, Lawlor DA, Kimm SY. Childhood obesity. Lancet 2010; 375: 1737-1748
- 10 Muckelbauer R, Libuda L, Clausen K et al. Promotion and provision of drinking water in schools for overweight prevention: randomized, controlled cluster trial. Pediatrics 2009; 123: e661-e667
- 11 James J, Kerr D. Prevention of childhood obesity by reducing soft drinks. Int J Obes (Lond) 2005; 29 (Suppl. 02) 54-57
- 12 Pereira MA, Kartashov AI, Ebbeling CB et al. Fast-food habits, weight gain, and insulin resistance (the CARDIA study): 15-year prospective analysis. Lancet 2005; 365: 36-42
- 13 Reinehr T, Hinney A, de Sousa G et al. Definable somatic disorders in overweight children and adolescents. J Pediatr 2007; 150: 618-622
- 14 Reinehr T, Dobe M, Winkel K et al. Adipositas bei behinderten Kindern und Jugendlichen. Eine therapeutisch vergessene Patientengruppe. Dtsch Arztebl Int 2010; 107: 268-275
- 15 Reinehr T, de Sousa G, Andler W. Hyperthyrotropinemia in obese children is reversible after weight loss and is not related to lipids. J Clin Endocrinol Metab 2006; 91: 3088-3091
- 16 Reinehr T, Kulle A, Wolters B et al. Relationships between 24-hour urinary free cortisol concentrations and metabolic syndrome in obese children. J Clin Endocrinol Metab 2014; 99: 2391-2399
- 17 Reinehr T, Andler W, Denzer C et al. Cardiovascular risk factors in overweight German children and adolescents: relation to gender, age and degree of overweight. Nutr Metab Cardiovasc Dis 2005; 15: 181-187
- 18 Hinney A, Vogel CI, Hebebrand J. From monogenic to polygenic obesity: recent advances. Eur Child Adolesc Psychiatry 2010; 19: 297-310
- 19 Hebebrand J, Friedel S, Schauble N et al. Perspectives: molecular genetic research in human obesity. Obes Rev 2003; 4: 139-146
- 20 Scherag A, Dina C, Hinney A et al. Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups. PLoS Genet 2010; 6: e1000916
- 21 Speliotes EK, Willer CJ, Berndt SI et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 2010; 42: 937-948
- 22 Kromeyer-Hausschild K, Gläßer N, Zellner K. Waist Circumference percentile in Jena children (Germany) 6 to 18 years of age. Aktuel Ernahrungsmed 2008; 33: 116-122
- 23 Wunsch R, de Sousa G, Reinehr T. Intima-media thickness in obesity: relation to hypertension and dyslipidaemia. Arch Dis Child 2005; 90: 1097
- 24 Reinehr T, Kiess W, de Sousa G et al. Intima media thickness in childhood obesity: relations to inflammatory marker, glucose metabolism, and blood pressure. Metabolism 2006; 55: 113-118
- 25 Roth CL, Kratz M, Ralston MM et al. Changes in adipose-derived inflammatory cytokines and chemokines after successful lifestyle intervention in obese children. Metabolism 2011; 60: 445-452
- 26 Bluher M. Adipokines – removing road blocks to obesity and diabetes therapy. Mol Metab 2014; 3: 230-240
- 27 Reinehr T. Type 2 diabetes mellitus in children and adolescents. World J Diabetes 2013; 4: 270-281
- 28 Wiegand S, Keller KM, Röbl M et al. Obese boys at increased risk for nonalcoholic liver disease: evaluation of 16 390 overweight or obese children and adolescents. Int J Obes (Lond) 2010; 34: 1468-1474
- 29 Dietz WH, Robinson TN. Clinical practice. Overweight children and adolescents. N Engl J Med 2005; 352: 2100-2109
- 30 Wille N, Bullinger M, Holl R et al. Health-related quality of life in overweight and obese youths: results of a multicenter study. Health Qual Life Outcomes 2010; 8: 36
- 31 Gortmaker SL, Must A, Perrin JM et al. Social and economic consequences of overweight in adolescence and young adulthood. N Engl J Med 1993; 329: 1008-1012
- 32 Holzapfel C, Landsberg B, Ried J et al. Prävention von Adipositas: Perspektiven, Chancen und Grenzen in Deutschland und Europa. Adipositas 2013; 7: 97-103
- 33 Sobol-Goldberg S, Rabinowitz J, Gross R. School-based obesity prevention programs: a meta-analysis of randomized controlled trials. Obesity (Silver Spring) 2013; 21: 2422-2428
- 34 Bleich SN, Segal J, Wu Y et al. Systematic review of community-based childhood obesity prevention studies. Pediatrics 2013; 132: e201-e210
- 35 Oude LH, Baur L, Jansen H et al. Interventions for treating obesity in children. Cochrane Database Syst Rev 2009; CD001872
- 36 Müller J, Reinehr T, Hebebrand J. Prävention und Therapie der Adipositas im Kindes- und Jugendalter. Deutsches Ärzteblatt 2006; 103: 334-340
- 37 Reinehr T, Kiess W, Kapellen T et al. Insulin sensitivity among obese children and adolescents, according to degree of weight loss. Pediatrics 2004; 114: 1569-1573
- 38 Wunsch R, de Sousa G, Toschke AM et al. Intima-media thickness in obese children before and after weight loss. Pediatrics 2006; 118: 2334-2340
- 39 Reinehr T, Dobe M, Kersting M. Tipps und Tricks von Obeldicks und Optimix: Der Ratgeber für Eltern übergewichtiger Kinder. 2.. Aufl. Göttingen: Hogrefe; 2009
- 40 Shai I, Schwarzfuchs D, Henkin Y et al. Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet. N Engl J Med 2008; 359: 229-241
- 41 Sacks FM, Bray GA, Carey VJ et al. Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates. N Engl J Med 2009; 360: 859-873
- 42 Reinehr T. Lifestyle intervention in childhood obesity: changes and challenges. Nat Rev Endocrinol 2013; 9: 607-614
- 43 Reinehr T, Roth CL. The gut sensor as regulator of body weight. Endocrine 2014; Epub ahead of print
- 44 Knop C, Singer V, Uysal Y et al. Extremely obese children respond better than extremely obese adolescents to lifestyle interventions. Pediatr Obes 2013; 10: 7-14
- 45 McGovern L, Johnson JN, Paulo R et al. Clinical review: treatment of pediatric obesity: a systematic review and meta-analysis of randomized trials. J Clin Endocrinol Metab 2008; 93: 4600-4605
- 46 Courcoulas AP, Christian NJ, Belle SH et al. Weight change and health outcomes at 3 years after bariatric surgery among individuals with severe obesity. JAMA 2013; 310: 2416-2425
- 47 Inge TH, Xanthakos S. Sleeve gastrectomy for childhood morbid obesity: why not?. Obes Surg 2010; 20: 118-120
- 48 Sjostrom L, Peltonen M, Jacobson P et al. Association of bariatric surgery with long-term remission of type 2 diabetes and with microvascular and macrovascular complications. JAMA 2014; 311: 2297-2304
- 49 Black JA, White B, Viner RM et al. Bariatric surgery for obese children and adolescents: a systematic review and meta-analysis. Obes Rev 2013; 14: 634-644
- 50 O'Brien PE, Sawyer SM, Laurie C et al. Laparoscopic adjustable gastric banding in severely obese adolescents: a randomized trial. JAMA 2010; 303: 519-526
- 51 Inge TH, Zeller MH, Jenkins TM et al. Perioperative outcomes of adolescents undergoing bariatric surgery: the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study. JAMA Pediatr 2014; 168: 47-53