Synthesis 2015; 47(17): 2641-2646
DOI: 10.1055/s-0034-1380752
paper
© Georg Thieme Verlag Stuttgart · New York

Palladium-Catalyzed Carbonylative Synthesis of N-Benzoylindoles with Mo(CO)6 as the Carbon Monoxide Source

Xiao-Feng Wu*
a   Department of Chemistry, Zhejiang Sci-Tech University, Xiasha Campus, Hangzhou Province, P. R. of China   eMail: xiao-feng.wu@catalysis.de
b   Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Str. 29a, 18059 Rostock, Germany
,
Stefan Oschatz
b   Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Str. 29a, 18059 Rostock, Germany
c   Universität Rostock, Institut für Chemie, Albert-Einstein-Str. 3a, 18059 Rostock, Germany   eMail: peter.langer@uni-rostock.de
,
Muhammad Sharif
b   Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Str. 29a, 18059 Rostock, Germany
,
Peter Langer*
b   Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Str. 29a, 18059 Rostock, Germany
c   Universität Rostock, Institut für Chemie, Albert-Einstein-Str. 3a, 18059 Rostock, Germany   eMail: peter.langer@uni-rostock.de
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Publikationsverlauf

Received: 12. Februar 2015

Accepted after revision: 16. April 2015

Publikationsdatum:
28. Mai 2015 (online)


Abstract

A mild and carbon monoxide gas-free palladium-catalyzed aminocarbonylation of indole has been developed for the synthesis of N-benzoylindoles. This method uses Mo(CO)6 as a convenient CO-precursor and BuPAd2 as the ligand. A number of substituents on the aryl bromide species is tolerated under the presented conditions and gave the desired products in up to excellent yields.

Supporting Information

 
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