Palladium-Catalyzed Carbonylative Synthesis of N-Benzoylindoles with Mo(CO)6 as the Carbon Monoxide Source

Xiao-Feng Wu; Stefan Oschatz; Muhammad Sharif; Peter Langer

doi:10.1055/s-0034-1380752

Synthesis, Inhaltsverzeichnis

Synthesis 2015; 47(17): 2641-2646
DOI: 10.1055/s-0034-1380752

paper

Palladium-Catalyzed Carbonylative Synthesis of N-Benzoylindoles with Mo(CO)₆ as the Carbon Monoxide Source

Xiao-Feng Wu*

^aDepartment of Chemistry, Zhejiang Sci-Tech University, Xiasha Campus, Hangzhou Province, P. R. of China eMail: xiao-feng.wu@catalysis.de

^bLeibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Str. 29a, 18059 Rostock, Germany

,

Stefan Oschatz

^bLeibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Str. 29a, 18059 Rostock, Germany

^cUniversität Rostock, Institut für Chemie, Albert-Einstein-Str. 3a, 18059 Rostock, Germany eMail: peter.langer@uni-rostock.de

,

Muhammad Sharif

^bLeibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Str. 29a, 18059 Rostock, Germany

,

Peter Langer*

^bLeibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Str. 29a, 18059 Rostock, Germany

^cUniversität Rostock, Institut für Chemie, Albert-Einstein-Str. 3a, 18059 Rostock, Germany eMail: peter.langer@uni-rostock.de

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Abstract

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Abstract

A mild and carbon monoxide gas-free palladium-catalyzed aminocarbonylation of indole has been developed for the synthesis of N-benzoylindoles. This method uses Mo(CO)₆ as a convenient CO-precursor and BuPAd₂ as the ligand. A number of substituents on the aryl bromide species is tolerated under the presented conditions and gave the desired products in up to excellent yields.

Key words

benzoylindole - aminocarbonylation - palladium catalyst - molybdenum hexacarbonyl - indole

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