Download PDF
Psychiatr Prax 2013; 40(04): 183-191
DOI: 10.1055/s-0033-1343138
Übersicht
© Georg Thieme Verlag KG Stuttgart · New York

Erfassung leichter kognitiver Störungen und demenzieller Erkrankungen in epidemiologischen Studien

Ein Überblick über den aktuellen Forschungsstand in DeutschlandAssessment of Mild Cognitive Impairment and Dementia in Epidemiologic StudiesAn Overview on the Current State of Research in Germany
Francisca S. Then   *
1   Institut für Sozialmedizin, Arbeitsmedizin und Public Health (ISAP), Universität Leipzig, Leipzig
2   LIFE – Leipziger Forschungszentrum für Zivilisationserkrankungen, Universität Leipzig, Leipzig
,
Tobias Luck   *
1   Institut für Sozialmedizin, Arbeitsmedizin und Public Health (ISAP), Universität Leipzig, Leipzig
2   LIFE – Leipziger Forschungszentrum für Zivilisationserkrankungen, Universität Leipzig, Leipzig
,
Frank Jacobi
3   Psychologische Hochschule Berlin (PHB), Berlin
,
Klaus Berger
4   Institut für Epidemiologie und Sozialmedizin, Universität Münster, Münster
,
Siegfried Weyerer
5   Zentralinstitut für Seelische Gesundheit, Medizinische Fakultät Mannheim/Universität Heidelberg, Mannheim
,
Hans-Jörgen Grabe
6   Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsmedizin Greifswald, HELIOS-Klinikum Stralsund, Stralsund
7   Deutsches Zentrum für Neurodegenerative Erkrankungen, Standort Rostock/Greifswald, Greifswald
,
Markus A. Busch
8   Robert Koch-Institut, Abteilung Epidemiologie und Gesundheitsmonitoring, Berlin
,
Michael Wagner
9   Klinik für Psychiatrie und Psychotherapie, Universität Bonn, Bonn
10   DZNE, Deutsches Zentrum für Neurodegenerative Erkrankungen, Bonn
,
Steffi G. Riedel-Heller
1   Institut für Sozialmedizin, Arbeitsmedizin und Public Health (ISAP), Universität Leipzig, Leipzig
› Author Affiliations
Further Information

Publication History

Publication Date:
05 April 2013 (online)

Also available at
    Permissions and Reprints

Zusammenfassung

Ziel: Bereitstellung eines Überblicks über die Erfassung leichter kognitiver Störungen und Demenzen in epidemiologischen Studien aus Deutschland.

Methodik: Es wurde eine Literaturrecherche in den Datenbanken Medline und PsycInfo durchgeführt.

Ergebnisse: Es konnten 31 Studien mit einem großen Spektrum an eingesetzten Untersuchungsinstrumenten identifiziert werden.

Schlussfolgerung: Weitere Bemühungen sind notwendig, um einen Kernsatz an Untersuchungsinstrumenten zu definieren, der eine harmonisierte Erfassung von leichten kognitiven Störungen und Demenzen in epidemiologischen Studien erlaubt.

Abstract

Objective: We sought to provide an overview on the assessment of mild cognitive impairment and dementia in epidemiological studies from Germany.

Methods: We conducted a literature search in the databases Pubmed and PsycInfo.

Results: Literature search identified 31 relevant studies using a broad spectrum of methods and neuropsychological instruments.

Conclusion: Further efforts are necessary to establish a generally accepted core set of instruments enabling a harmonized assessment of mild cognitive impairment and dementia in epidemiological studies. Such a core set should comprise neuropsychological tests but also standardized questionnaires on subjective cognitive impairment and impairment in activities of daily living. If possible, third-party information (proxy interviews) should be included.

Schlüsselwörter

Demenz - Kognition - Epidemiologie - Kohortenstudien - Übersichtsarbeit

Keywords

dementia - cognition - epidemiology - cohort studies - review

* geteilte Erstautorenschaft


 

  • Literatur

  • 1 Wancata J, Musalek M, Alexandrowicz R et al. Number of dementia sufferers in Europe between the years 2000 and 2050. Eur Psychiatry 2003; 18: 306-313
    CrossrefPubMedGoogle Scholar
  • 2 Leicht H, König HH. Costs of illness in dementia from a societal perspective. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2012; 55: 677-684
    PubMedGoogle Scholar
  • 3 Mura T, Dartigues JF, Berr C. How many dementia cases in France and Europe? Alternative projections and scenarios 2010-2050. Eur J Neurol 2010; 17: 252-259
    CrossrefPubMedGoogle Scholar
  • 4 Luppa M, Luck T, Weyerer S et al. Prediction of institutionalization in the elderly. A systematic review. Age Ageing 2010; 39: 31-38
    CrossrefPubMedGoogle Scholar
  • 5 Beekmann M, van den Bussche H, Glaeske G et al. Geriatrietypische Morbiditätsmuster und Pflegebedürftigkeit bei Patienten mit Demenz. Psychiat Prax 2012; 39: 222-227
    Article in Thieme ConnectPubMedGoogle Scholar
  • 6 Mitchell SL, Black BS, Ersek M et al. Advanced Dementia: State of the Art and Priorities for the Next Decade. Ann Internal Med 2012; 156: 45-95
    CrossrefPubMedGoogle Scholar
  • 7 Luck T, Luppa M, Angermeyer MC et al. Leichte kognitive Beeinträchtigung und Demenzen – Eine Bevölkerungsperspektive. Ergebnisse der Leipziger Langzeitstudie in der Altenbevölkerung (LEILA75+). Sächs Ärztebl 2011; 8: 426-431
    PubMedGoogle Scholar
  • 8 Jacobi F, Mack S, Gerschler A et al. The Design and Methods of the Mental Health Module in the German Health Interview and Examination Survey for Adults (DEGS1-MH). Int J Meth Psychiatric Res [im Druck]
    PubMedGoogle Scholar
  • 9 Scheidt-Nave C, Kamtsiuris P, Gößwald A et al. German Health Interview and Examination Survey for Adults (DEGS) – design, objectives and implementation of the first data collection wave. BMC Pub Health 2012; 12: 730
    CrossrefPubMedGoogle Scholar
  • 10 Berkemeyer S, Schumacher J, Thiem U et al. Bone T-scores and functional status: a cross-sectional study on German elderly. PLoS One 2009; 4: e8216
    CrossrefPubMedGoogle Scholar
  • 11 Schneekloth U. Entwicklungstrends und Perspektiven in der häuslichen Pflege: Zentrale Ergebnisse der Studie Möglichkeiten und Grenzen selbstständiger Lebensführung (MuG III). Z Gerontol Geriatrie 2006; 39: 405-412
    PubMedGoogle Scholar
  • 12 Schneekloth U, Wahl HW. Möglichkeiten und Grenzen selbstständiger Lebensführung in privaten Haushalten (MUG III): Repräsentativbefunde und Vertiefungsstudien zu häuslichen Pflegearrangements, Demenz und professionellen Versorgungsangeboten. München: Bundesministerium für Familie, Senioren, Frauen und Jugend; 2005
    Google Scholar
  • 13 John U, Greiner B, Hensel E et al. Study of Health In Pomerania (SHIP): a health examination survey in an east German region: objectives and design. Soz Praventivmed 2001; 46: 186-194
    CrossrefPubMedGoogle Scholar
  • 14 Grabe HJ, Schwahn C, Volzke H et al. Tooth loss and cognitive impairment. J Clin Periodontol 2009; 36: 550-557
    CrossrefPubMedGoogle Scholar
  • 15 Volzke H, Alte D, Schmidt CO et al. Cohort profile: the study of health in Pomerania. Int J Epidemiol 2011; 40: 294-307
    CrossrefPubMedGoogle Scholar
  • 16 Jessen F, Wiese B, Bachmann C et al. Prediction of dementia by subjective memory impairment: effects of severity and temporal association with cognitive impairment. Arch Gen Psychiatry 2010; 67: 414-422
    CrossrefPubMedGoogle Scholar
  • 17 Pentzek M, Wollny A, Wiese B et al. Apart from nihilism and stigma: what influences general practitioners' accuracy in identifying incident dementia?. Am J Geriatr Psychiatry 2009; 17: 965-975
    CrossrefPubMedGoogle Scholar
  • 18 Kornhuber J, Schmidtke K, Frolich L et al. Early and differential diagnosis of dementia and mild cognitive impairment: design and cohort baseline characteristics of the German Dementia Competence Network. Dement Geriatr Cogn Disord 2009; 27: 404-417
    CrossrefPubMedGoogle Scholar
  • 19 Kaduszkiewicz H, Zimmermann T, van den Bussche H et al. Do general practitioners recognize mild cognitive impairment in their patients?. J Nutr Health Aging 2010; 14: 697-702
    CrossrefPubMedGoogle Scholar
  • 20 Breitling LP, Wolf M, Muller H et al. Large-scale application of a telephone-based test of cognitive functioning in older adults. Dement Geriatr Cogn Disord 2010; 30: 309-316
    CrossrefPubMedGoogle Scholar
  • 21 Dlugaj M, Weimar C, Wege N et al. Prevalence of mild cognitive impairment and its subtypes in the Heinz Nixdorf Recall study cohort. Dement Geriatr Cogn Disord 2010; 30: 362-373
    CrossrefPubMedGoogle Scholar
  • 22 Dragano N, He Y, Moebus S et al. Two models of job stress and depressive symptoms: Results from a population-based study. Soc Psychiatry Psychiatr Epidemiol 2008; 43: 72-78
    CrossrefPubMedGoogle Scholar
  • 23 Kalsch H, Lehmann N, Mohlenkamp S et al. Association of coronary artery calcium and congestive heart failure in the general population: Results of the Heinz Nixdorf Recall study. Clin Res Cardiol 2010; 99: 175-182
    CrossrefPubMedGoogle Scholar
  • 24 Luck T, Luppa M, Briel S et al. Mild cognitive impairment: incidence and risk factors: results of the leipzig longitudinal study of the aged. J Am Geriatr Soc 2010; 58: 1903-1910
    CrossrefPubMedGoogle Scholar
  • 25 Luck T, Busse A, Hensel A et al. Leichte kognitive Beeinträchtigungen und Demenzentwicklung: Ergebnisse einer bevölkerungsrepräsentativen Längsschnittstudie (LEILA 75+). Psychiat Prax 2008; 35: 331-336
    Article in Thieme ConnectPubMedGoogle Scholar
  • 26 Jakob A, Busse A, Riedel-Heller SG et al. Prevalence and incidence of dementia among nursing home residents and residents in homes for the aged in comparison to private homes. Z Gerontol Geriatr 2002; 35: 474-481
    CrossrefPubMedGoogle Scholar
  • 27 Aurich C, Singer S, Matschinger H et al. Abbau kognitiver Leistungen bei Hochbetagten im SIDAM. Plädoyer für eine Altersnormierung von Demenztests. Z Gerontopsychologie -psychiatrie 2001; 14: 113-122
    PubMedGoogle Scholar
  • 28 Toro P, Schonknecht P, Schroder J. Type II diabetes in mild cognitive impairment and Alzheimer's disease: results from a prospective population-based study in Germany. J Alzheimers Dis 2009; 16: 687-691
    PubMedGoogle Scholar
  • 29 Schonknecht P, Pantel J, Kruse A et al. Prevalence and natural course of aging-associated cognitive decline in a population-based sample of young-old subjects. Am J Psychiatry 2005; 162: 2071-2077
    CrossrefPubMedGoogle Scholar
  • 30 Thomann PA, Wustenberg T, Pantel J et al. Structural changes of the corpus callosum in mild cognitive impairment and Alzheimer's disease. Dement Geriatr Cogn Disord 2006; 21: 215-220
    CrossrefPubMedGoogle Scholar
  • 31 Gerstorf D, Ram N, Röcke C et al. Decline in life satisfaction in old age: Longitudinal evidence for links to distance-to-death. Psychology Aging 2008; 23: 154-168
    CrossrefPubMedGoogle Scholar
  • 32 Wernicke TF, Linden M, Gilberg R et al. Ranges of psychiatric morbidity in the old and the very old – results from the Berlin Aging Study (BASE). Eur Arch Psychiatry Clin Neurosci 2000; 250: 111-119
    CrossrefPubMedGoogle Scholar
  • 33 Verhaeghen P, Borchelt M, Smith J. Relation between cardiovascular and metabolic disease and cognition in very old age: Cross-sectional and longitudinal findings from the Berlin Aging Study. Health Psychology 2003; 22: 559-569
    CrossrefPubMedGoogle Scholar
  • 34 Gerstorf D, Herlitz A, Smith J. Stability of sex differences in cognition in advanced old age: The role of education and attrition. J Gerontology Ser B: Psychol Sci Soc Sci 2006; 61B: 245-249
    PubMedGoogle Scholar
  • 35 Schaub RT, Münzberg H, Borchelt M et al. Ventilatory capacity and risk for dementia. J Gerontology Ser A: Biol Sci Med Sci 2000; 55: M677-M683
    PubMedGoogle Scholar
  • 36 Meller I, Fichter M, Schroppel H. Institutional care for the very old. Results of the Munich study of the very old. Fortschr Neurol Psychiatr 2000; 68: 270-277
    Article in Thieme ConnectPubMedGoogle Scholar
  • 37 Meller I, Fichter MM, Schroppel H. Mortality risk in the octo- and nonagenerians: longitudinal results of an epidemiological follow-up community study. Eur Arch Psychiatry Clin Neurosci 1999; 249: 180-189
    CrossrefPubMedGoogle Scholar
  • 38 Fichter MM, Schroppel H, Meller I. Incidence of dementia in a Munich community sample of the oldest old. Eur Arch Psychiatry Clin Neurosci 1996; 246: 320-328
    CrossrefPubMedGoogle Scholar
  • 39 Fichter MM, Meller I, Schroppel H et al. Dementia and cognitive impairment in the oldest old in the community. Prevalence and comorbidity. Br J Psychiatry 1995; 166: 621-629
    CrossrefPubMedGoogle Scholar
  • 40 Schmidt WP, Roesler A, Kretzschmar K et al. Functional and Cognitive Consequences of Silent Stroke Discovered Using Brain Magnetic Resonance Imaging in an Elderly Population. J Am Geriatr Society 2004; 52: 1045-1050
    PubMedGoogle Scholar
  • 41 Baune BT, Suslow T, Engelien A et al. The Association between Depressive Mood and Cognitive Performance in an Elderly General Population – The MEMO Study. Dem Geriatr Cog Dis 2006; 22: 142-149
    PubMedGoogle Scholar
  • 42 Cooper B, Bickel H, Schaufele M. Early development and progression of dementing illness in the elderly: a general-practice based study. Psychol Med 1996; 26: 411-419
    CrossrefPubMedGoogle Scholar
  • 43 Cooper B, Bickel H, Schäufele M. Demenzerkrankungen und leichtere kognitive Beeinträchtigungen bei älteren Patienten in der ärztlichen Allgemeinpraxis: Ergebnisse einer Querschnittsuntersuchung. Nervenarzt 1992; 63: 551-560
    PubMedGoogle Scholar
  • 44 Bickel H, Cooper B. Incidence and relative risk of dementia in an urban elderly population: findings of a prospective field study. Psychol Med 1994; 24: 179-192
    CrossrefPubMedGoogle Scholar
  • 45 Cooper B, Bickel H. Prevalence and incidence of dementia diseases in the elderly population. Results of a population-related longitudinal study in Mannheim. Nervenarzt 1989; 60: 472-482
    PubMedGoogle Scholar
  • 46 Bickel H, Ambros C, Schulze Beerhorst B et al. Retrospektive Demenzeinschätzung durch Informantenbefragungen: Ergebnisse zur Validität und zur Inter-Rater-Reliabilität. Z Gerontopsychologie -psychiatrie 1993; 6: 175-182
    PubMedGoogle Scholar
  • 47 Bickel H. Need for nursing care by the elderly: results of a population based retrospective longitudinal study. Gesundheitswesen 1996; 58: 56-62
    PubMedGoogle Scholar
  • 48 Schikowski T, Ranft U, Sugiri D et al. Decline in air pollution and change in prevalence in respiratory symptoms and chronic obstructive pulmonary disease in elderly women. Respir Res 2010; 11: 113
    CrossrefPubMedGoogle Scholar
  • 49 Schikowski T, Sugiri D, Ranft U et al. Does respiratory health contribute to the effects of long-term air pollution exposure on cardiovascular mortality?. Respir Res 2007; 8: 20
    CrossrefPubMedGoogle Scholar
  • 50 Ranft U, Schikowski T, Sugiri D et al. Long-term exposure to traffic-related particulate matter impairs cognitive function in the elderly. Environ Res 2009; 109: 1004-1011
    CrossrefPubMedGoogle Scholar
  • 51 Dilling H, Weyerer S. Psychische Erkrankungen in der Bevölkerung bei Erwachsenen und Jugendlichen. In: Dilling H, Weyerer S, Castell R. Psychische Erkrankungen in der Bevölkerung. Eine Felduntersuchung zur psychiatrischen Morbidität und zur Inanspruchnahme ärztlicher Institutionen in drei kleinstädtisch-ländlichen Gemeinden des Landkreises Traunstein/Oberbayern. Stuttgart: Ferdinand Enke Verlag; 1984: 1-121
    Google Scholar
  • 52 Fichter MM. Verlauf psychischer Erkrankungen in der Bevölkerung. Berlin, Heidelberg, New York, Tokyo: Springer; 1990
    CrossrefGoogle Scholar
  • 53 Weyerer S, Dilling H. Prävalenz und Behandlung psychischer Erkrankungen in der Allgemeinbevölkerung. Ergebnisse einer Feldstudie in drei Gemeinden Oberbayerns. Nervenarzt 1984; 55: 30-42
    PubMedGoogle Scholar
  • 54 Dilling H, Weyerer S. Prevalence of mental disorders in the small-town – rural region of Traunstein (Upper Bavaria). Acta Psychiatr Scand 1984; 69: 60-70
    CrossrefPubMedGoogle Scholar
  • 55 Weyerer S. Mental disorders among the elderly. True prevalence and use of medical services. Arch Gerontol Geriatr 1983; 2: 11-22
    CrossrefPubMedGoogle Scholar
  • 56 Wersching H, Berger K. Neue Kohorten: BiDirect-Studie. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2012; 55: 822-823
    PubMedGoogle Scholar
  • 57 Schäufele M, Köhler L, Lode S et al. Menschen mit Demenz in stationären Pflegeeinrichtungen: aktuelle Lebens- und Versorgungssituation. In: Schneekloth U, Wahl HW. Pflegebedarf und Versorgungssituation bei älteren Menschen in Heimen. Demenz, Angehörige und Freiwillige, Beispiele für Good Practice. Stuttgart: Kohlhammer; 2009: 159-221
    Google Scholar
  • 58 Bickel H, Kurz A. Education, occupation, and dementia: the Bavarian school sisters study. Dement Geriatr Cogn Disord 2009; 27: 548-556
    CrossrefPubMedGoogle Scholar
  • 59 Bickel H, Riemenschneider M, Kurz A. Associations between dementia and head circumference as a measure of brain reserve – results from the Bavarian School sisters study. Psychiat Prax 2006; 33: 138-144
    Article in Thieme ConnectPubMedGoogle Scholar
  • 60 Etgen T, Sander D, Huntgeburth U et al. Physical activity and incident cognitive impairment in elderly persons: the INVADE study. Arch Intern Med 2010; 170: 186-193
    CrossrefPubMedGoogle Scholar
  • 61 Scherpinski U, Bickel H, Gnahn H et al. Intervention project on cerebrovascular diseases and dementia in the Ebersberg district (INVADE): rationale and design. Nervenarzt 2002; 73: 1199-1204
    CrossrefPubMedGoogle Scholar
  • 62 Becker C, Eichner B, Lindemann B et al. Abilities and restrictions of nursing home residents. Evaluation with the Minimum Data Set of the Resident Assessment Instrument. Z Gerontol Geriatr 2003; 36: 260-265
    CrossrefPubMedGoogle Scholar
  • 63 Weyerer S, Schaufele M, Schrag A et al. Dementia disorders, behavior problems and the care of clients in geriatric day-care compared to residents in homes for the elderly: a cross-sectional study in eight communities in Baden. Psychiat Prax 2004; 31: 339-345
    Article in Thieme ConnectPubMedGoogle Scholar
  • 64 Klostermann M, Steinkamp G, Tropberger F et al. Patient management in geriatric psychiatry by ambulatory care services. Results of an empirical analysis. Z Gerontol Geriatr 1998; 31: 426-437
    CrossrefPubMedGoogle Scholar
  • 65 Winblad B, Palmer K, Kivipelto M et al. Mild cognitive impairment – beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. J Intern Med 2004; 256: 240-246
    CrossrefPubMedGoogle Scholar
  • 66 Kidd PM. Alzheimer's disease, amnestic mild cognitive impairment, and age-associated memory impairment: current understanding and progress toward integrative prevention. Altern Med Rev 2008; 13: 85-115
    PubMedGoogle Scholar
  • 67 Panza F, Frisardi V, Capurso C et al. Late-Life Depression, Mild Cognitive Impairment, and Dementia: Possible Continuum?. Am J Geriatr Psychiatry 2010; 18: 98-116
    CrossrefPubMedGoogle Scholar
  • 68 Nasreddine ZS, Phillips NA, Bedirian V et al. The montreal cognitive assessment, MoCA: A brief screening tool for mild cognitive impairment. J Am Geriatr Society 2005; 53: 695-699
    PubMedGoogle Scholar
  • 69 Dong YH, Lee WY, Basri NA et al. The Montreal Cognitive Assessment is superior to the Mini-Mental State Examination in detecting patients at higher risk of dementia. Int Psychogeriatr 2012; 24: 1749-1755
    CrossrefPubMedGoogle Scholar
  • 70 Markwick A, Zamboni G, de Jager CA. Profiles of cognitive subtest impairment in the Montreal Cognitive Assessment (MoCA) in a research cohort with normal Mini-Mental State Examination (MMSE) scores. J Clin Exp Neuropsychology 2012; 34: 750-757
    CrossrefPubMedGoogle Scholar